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PEPDIA-INT-003414

Gold

Endothelin-1

Quality

Source DBs

Activities

Source refs

Literature

Patents

Integrated record

Sequence and molecular profile

CSCSSLMDKECVYFCHLDIIW

Indexed sequence21 aa

1CSCSSLMDKECVYFCHLDIIW

Length

Molecular weight

2495.98 Da

Formula

C109H163N25O32S5

Structure type

Linear

Synthesis

Chirality

Family

Gene

Residue composition

Physicochemical profile

Hydrophobic9

Membrane affinity proxy

Polar7

Solubility proxy

Charged5

Net charge proxy -1

Aromatic4

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

2495.9335 Da

Molecular formula

C109H163N25O32S5

Theoretical pI

4.5364

Net charge at pH 7

-2.1893

GRAVY

0.6333

Instability index

59.4429

Aromaticity

0.1429

Topological polar surface area

908.63 Å²

cLogP

-5.7921

Hydrogen-bond donors

Hydrogen-bond acceptors

Rotatable bonds

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

CSCSSLMDKECVYFCHLDIIW

HELM 2.0

validated simple linear

PEPTIDE1{C.S.C.S.S.L.M.D.K.E.C.V.Y.F.C.H.L.D.I.I.W}$$$$V2.0

Canonical SMILES

validated

CCC(C)C(NC(=O)C(CC(=O)O)NC(=O)C(CC(C)C)NC(=O)C(Cc1c[nH]cn1)NC(=O)C(CS)NC(=O)C(Cc1ccccc1)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(NC(=O)C(CS)NC(=O)C(CCC(=O)O)NC(=O)C(CCCCN)NC(=O)C(CC(=O)O)NC(=O)C(CCSC)NC(=O)C(CC(C)C)NC(=O)C(CO)NC(=O)C(CO)NC(=O)C(CS)NC(=O)C(CO)NC(=O)C(N)CS)C(C)C)C(=O)NC(C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)O)C(C)CC

Isomeric SMILES

validated

CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CS)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CS)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CS)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CS)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.

Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.

Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-003414,
  title = {Endothelin-1},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-003414},
  note = {Accessed from local PepDiana development build}
}

APA-style note

Endothelin-1. (2026). PepDiana record PEPDIA-INT-003414. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-003414

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (9 records)

Stable record	Activity	Subtype	Value	Target	Assay method	Source
CTPDB_P003414_ACT_satpdb_0000	Bioregulatory	Cell-Cell Communication	Not available in the current structured import	Unknown	Not reported by source	satpdb19171satpdb / linked
CTPDB_P003414_ACT_satpdb_0001	Cell-Penetrating	Drug Delivery	Not available in the current structured import	Unknown	Not reported by source	satpdb19238satpdb / linked
CTPDB_P003414_ACT_thpdb_0002	Clinical / Approved Drug	General Therapeutic	Not available in the current structured import	Unknown	Not reported by source	Th1517_14566_rec0thpdb / unavailable
CTPDB_P003414_ACT_thpdb_0003	Clinical / Approved Drug	General Therapeutic	Not available in the current structured import	Unknown	Not reported by source	Th1517_14567_rec1thpdb / unavailable
CTPDB_P003414_ACT_thpdb_0004	Clinical / Approved Drug	General Therapeutic	Not available in the current structured import	Unknown	Not reported by source	Th1517_14568_rec2thpdb / unavailable
CTPDB_P003414_ACT_thpdb_0005	Clinical / Approved Drug	General Therapeutic	Not available in the current structured import	Unknown	Not reported by source	Th1517_14569_rec3thpdb / unavailable
CTPDB_P003414_ACT_thpdb_0006	Clinical / Approved Drug	General Therapeutic	Not available in the current structured import	Unknown	Not reported by source	Th1517_14570_rec4thpdb / unavailable
CTPDB_P003414_ACT_thpdb_0007	Clinical / Approved Drug	General Therapeutic	Not available in the current structured import	Unknown	Not reported by source	Th1517_14571_rec5thpdb / unavailable
CTPDB_P003414_ACT_thpdb_0008	Clinical / Approved Drug	General Therapeutic	Not available in the current structured import	Unknown	Not reported by source	Th1517_14572_rec6thpdb / unavailable

Provenance

Source database records (10)

b3pdb

b3pdb_0718

Raw sequence

CSCSSLMDKECVYFCHLDIIW

satpdb

satpdb19171

Raw sequence

CSCSSLMDKECVYFCHLDIIW

satpdb

satpdb19238

Raw sequence

CSCSSLMDKECVYFCHLDIIW

thpdb

Th1517_14566_rec0

Raw sequence

CSCSSLMDKECVYFCHLDIIW

thpdb

Th1517_14567_rec1

Raw sequence

CSCSSLMDKECVYFCHLDIIW

thpdb

Th1517_14568_rec2

Raw sequence

CSCSSLMDKECVYFCHLDIIW

thpdb

Th1517_14569_rec3

Raw sequence

CSCSSLMDKECVYFCHLDIIW

thpdb

Th1517_14570_rec4

Raw sequence

CSCSSLMDKECVYFCHLDIIW

thpdb

Th1517_14571_rec5

Raw sequence

CSCSSLMDKECVYFCHLDIIW

thpdb

Th1517_14572_rec6

Raw sequence

CSCSSLMDKECVYFCHLDIIW

Citation trail

Literature (1 records)

{"pubmed_id": "[NA](https://www.ncbi.nlm.nih.gov/pubmed/?term=NA)"}

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:13.664756+00:00

Modification summary

No structured modification annotations are available for this record.

Source metadata

[
  {
    "source_db": "b3pdb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "satpdb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "thpdb",
    "organism_name": "Unknown"
  }
]

Structure metadata

{
  "source_db": "satpdb",
  "dssp_states": "CCCCSSSGGGSTTTSTTTSCC"
}