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PEPDIA-INT-003261

Gold

Cyclo(His-Tyr)

80

Quality

5

Source DBs

35

Activities

19

Source refs

15

Literature

0

Patents

Integrated record

Sequence and molecular profile

HY
Indexed sequence2 aa
1HY

Length

2

Molecular weight

318.33 Da

Formula

C15H18N4O4

Structure type

Linear

Synthesis

Synthetic

Chirality

L

Family

-

Gene

-

Residue composition

H
1
Y
1

Physicochemical profile

Hydrophobic1

Membrane affinity proxy

Polar0

Solubility proxy

Charged1

Net charge proxy +1

Aromatic2

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

318.3278 Da

Molecular formula

C15H18N4O4

Theoretical pI

6.7402

Net charge at pH 7

-0.1537

GRAVY

-2.25

Instability index

224.7

Aromaticity

0.5

Topological polar surface area

141.33 Ų

cLogP

-0.2028

Hydrogen-bond donors

5

Hydrogen-bond acceptors

5

Rotatable bonds

7

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

HY

HELM 2.0

validated simple linear

PEPTIDE1{H.Y}$$$$V2.0

Canonical SMILES

validated

NC(Cc1c[nH]cn1)C(=O)NC(Cc1ccc(O)cc1)C(=O)O

Isomeric SMILES

validated

N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.

Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.

Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-003261,
  title = {Cyclo(His-Tyr)},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-003261},
  note = {Accessed from local PepDiana development build}
}

APA-style note

Cyclo(His-Tyr). (2026). PepDiana record PEPDIA-INT-003261. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-003261

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (35 records)

Stable recordActivitySubtypeValueTargetAssay methodSource
CTPDB_P003261_ACT_ahtpdb_0004Metabolic/CardiovascularACE InhibitorNot available for this observationUnknownNot reported by source1144ahtpdb / linked
CTPDB_P003261_ACT_ahtpdb_0005Metabolic/CardiovascularACE Inhibitor20.0 mMUnknownNot reported by source1369ahtpdb / linked
CTPDB_P003261_ACT_ahtpdb_0006Metabolic/CardiovascularACE InhibitorNot available for this observationUnknownCushman and Cheung (1971)1916ahtpdb / linked
CTPDB_P003261_ACT_ahtpdb_0007Metabolic/CardiovascularACE InhibitorNot available for this observationUnknownNot reported by source3203ahtpdb / linked
CTPDB_P003261_ACT_ahtpdb_0008Metabolic/CardiovascularACE InhibitorNot available for this observationUnknownNot reported by source3498ahtpdb / linked
CTPDB_P003261_ACT_ahtpdb_0009Metabolic/CardiovascularACE InhibitorNot available for this observationUnknownNot reported by source3943ahtpdb / linked
CTPDB_P003261_ACT_ahtpdb_0000Metabolic/CardiovascularACE InhibitorNot available for this observationUnknownNot reported by source4077ahtpdb / linked
CTPDB_P003261_ACT_ahtpdb_0001Metabolic/CardiovascularACE Inhibitor26.1 µMUnknownNot reported by source4240ahtpdb / linked
CTPDB_P003261_ACT_ahtpdb_0002Metabolic/CardiovascularACE InhibitorNot available for this observationUnknownNot reported by source4734ahtpdb / linked
CTPDB_P003261_ACT_ahtpdb_0003Metabolic/CardiovascularACE InhibitorNot available for this observationUnknownNot reported by source4960ahtpdb / linked
CTPDB_P003261_ACT_ahtpdb_0010Metabolic/CardiovascularACE Inhibitor26.1 µMUnknownNot reported by source5154ahtpdb / linked
CTPDB_P003261_ACT_ahtpdb_0011Metabolic/CardiovascularACE InhibitorNot available for this observationUnknownNot reported by source5593ahtpdb / linked
CTPDB_P003261_ACT_ahtpdb_0012Metabolic/CardiovascularACE Inhibitor26.1 µMUnknownCushman and Cheung (1971)6150ahtpdb / linked
CTPDB_P003261_ACT_ahtpdb_0013Metabolic/CardiovascularACE Inhibitor26.1 µMUnknownNot reported by source6413ahtpdb / linked
CTPDB_P003261_ACT_dbaasp_0014Antimicrobial-500 µg/mlStaphylococcus aureusNot reported by sourceDBAASPS_18936_chain0dbaasp / linked
CTPDB_P003261_ACT_dbaasp_0015Antimicrobial-500 µg/mlStreptococcus pyogenesNot reported by sourceDBAASPS_18936_chain0dbaasp / linked
CTPDB_P003261_ACT_dbaasp_0016Antimicrobial-500 µg/mlBacillus subtilisNot reported by sourceDBAASPS_18936_chain0dbaasp / linked
CTPDB_P003261_ACT_dbaasp_0017Antimicrobial-500 µg/mlEscherichia coliNot reported by sourceDBAASPS_18936_chain0dbaasp / linked
CTPDB_P003261_ACT_dbaasp_0018Antimicrobial-500 µg/mlPseudomonas aeruginosaNot reported by sourceDBAASPS_18936_chain0dbaasp / linked
CTPDB_P003261_ACT_dbaasp_0019Antimicrobial-NAKlebsiella pneumoniaeNot reported by sourceDBAASPS_18936_chain0dbaasp / linked
CTPDB_P003261_ACT_dbaasp_0020Antimicrobial-500 µg/mlSalmonella typhimuriumNot reported by sourceDBAASPS_18936_chain0dbaasp / linked
CTPDB_P003261_ACT_dbaasp_0021Antimicrobial-500 µg/mlCandida albicansNot reported by sourceDBAASPS_18936_chain0dbaasp / linked
CTPDB_P003261_ACT_dbaasp_0022Antimicrobial-1000 µMHuman esophageal squamous cell carcinoma WHCO3Not reported by sourceDBAASPS_18936_chain0dbaasp / linked
CTPDB_P003261_ACT_dbaasp_0023Antimicrobial-25 µg/mlEscherichia coli MTCC 443Not reported by sourceDBAASPS_21308_chain0dbaasp / linked
CTPDB_P003261_ACT_dbaasp_0024Antimicrobial-125 µg/mlPseudomonas aeruginosa MTCC 1688Not reported by sourceDBAASPS_21308_chain0dbaasp / linked
CTPDB_P003261_ACT_dbaasp_0025Antimicrobial-150 µg/mlStaphylococcus aureus MTCC 96Not reported by sourceDBAASPS_21308_chain0dbaasp / linked
CTPDB_P003261_ACT_dbaasp_0026Antimicrobial-90 µg/mlStreptococcus pyogenes MTCC 442Not reported by sourceDBAASPS_21308_chain0dbaasp / linked
CTPDB_P003261_ACT_dbaasp_0027Antimicrobial-80 µg/mlCandida albicans MTCC 227Not reported by sourceDBAASPS_21308_chain0dbaasp / linked
CTPDB_P003261_ACT_dbaasp_0028Antimicrobial-70 µg/mlAspergillus niger MTCC 282Not reported by sourceDBAASPS_21308_chain0dbaasp / linked
CTPDB_P003261_ACT_dramp_0029Antimicrobial-Not available in the current structured importUnknownNot reported by sourceDRAMP34650dramp / linked
CTPDB_P003261_ACT_dramp_0030Anticancer-Not available in the current structured importUnknownNot reported by sourceDRAMP34650dramp / linked
CTPDB_P003261_ACT_plantpepdb_0031Enzyme InhibitorGeneral Enzyme InhibitorNot available in the current structured importUnknownNot reported by sourcePPepDB_2914plantpepdb / linked
CTPDB_P003261_ACT_plantpepdb_0032Neuroactive/Ion ChannelNeuropeptideNot available in the current structured importUnknownNot reported by sourcePPepDB_2914plantpepdb / linked
CTPDB_P003261_ACT_plantpepdb_0033Metabolic/CardiovascularAntihypertensiveNot available for this observationUnknownNot reported by sourcePPepDB_2914plantpepdb / linked
CTPDB_P003261_ACT_satpdb_0034Metabolic/CardiovascularAntihypertensiveNot available for this observationUnknownNot reported by sourcesatpdb10080satpdb / linked

Provenance

Source database records (19)

ahtpdb

4077

Raw sequence

HY

ahtpdb

4240

Raw sequence

HY

ahtpdb

4734

Raw sequence

HY

ahtpdb

4960

Raw sequence

HY

ahtpdb

1144

Raw sequence

HY

ahtpdb

1369

Raw sequence

HY

ahtpdb

1916

Raw sequence

HY

ahtpdb

6150

Raw sequence

HY

ahtpdb

6413

Raw sequence

HY

ahtpdb

5154

Raw sequence

HY

ahtpdb

5593

Raw sequence

HY

ahtpdb

3203

Raw sequence

HY

ahtpdb

3498

Raw sequence

HY

ahtpdb

3943

Raw sequence

HY

dbaasp

DBAASPS_18936_chain0

Raw sequence

HY

dbaasp

DBAASPS_21308_chain0

Raw sequence

HY

dramp

DRAMP34650

Raw sequence

HY

plantpepdb

PPepDB_2914

Raw sequence

HY

satpdb

satpdb10080

Raw sequence

HY

Citation trail

Literature (15 records)

Analysis of Domains in Selected Plant and Animal Food Proteins - Precursors of Biologically Active Peptides - In Silico Approach

A. Iwaniak, J. Dziuba

Food Science and Technology International 01/2009; 15(2):179-191.2009

Antihypertensive peptides from food proteins: a review.

Martínez-Maqueda D1, Miralles B, Recio I, Hernández-Ledesma B.

Food Funct. 2012 Apr;3(4):350-61.2012PMID 22249830

What are the ideal properties for functional food peptides with antihypertensive effect? A computational peptidology approach.

Zhou P et al.

Food Chem. 2013 Dec 1;141(3):2967-73.2013PMID 23871047

Is the structural diversity of tripeptides sufficient for developing functional food additives with satisfactory multiple bioactivities?

Jian-Hui Wang et al.,

Journal of Molecular Structure 1040 (2013) 164-1702013

MILK PROTEINS AS PRECURSORS OF BIOACTIVE PEPTIDES

Marta Dziuba, Bart?omiej Dziuba, Anna Iwaniak

Acta Sci. Pol.,Technol. Aliment. 8(1) 2009,71-902009

Structural requirements of Angiotensin I-converting enzyme inhibitory peptides: quantitative structure-activity relationship study of di- and tripeptides.

Wu J1, Aluko RE, Nakai S.

J Agric Food Chem. 2006 Feb 8;54(3):732-8.2006PMID 16448176

Vegetable foods: A cheap source of proteins and peptides with antihypertensive, antioxidant, and other less occurrence bioactivities.

M C García, P Puchalska, C Esteve, M L Marina

Talanta 03/2013; 106C:328-349.2013PMID 23598136

Structure and activity of angiotensin I converting enzyme inhibitory peptides from sake and sake lees

Saito, Y et al.,

Biosc Biotechnol Biochem 58 p.1767-711994PMID 7765503

Integration of QSAR modelling and QM/MM analysis to investigate functional food peptides with antihypertensive activity

Jin Tan et al.

Molecular Simulation Volume 39, Issue 12, 20132013

Bioactive peptides in amaranth (Amaranthus hypochondriacus) seed

Silva-Sanchez, C et al.

J Agric Food Chem 56 p.1233-402008PMID 18211015

Animal and Plant Proteins as Precursors of Peptides with ACE Inhibitory Activity – An in silico Strategy of Protein Evaluation

Anna Iwaniak and Jerzy Dziuba

Food Technol. Biotechnol. 47 (4) 441–449 (2009)2009

MOTIFS WITH POTENTIAL PHYSIOLOGICAL ACTIVITY IN FOOD PROTEINS - BIOPEP DATABASE

Iwaniak, Anna; Dziuba, Bartlomiej

Acta Scientiarum Polonorum. Technologia Alimentaria;2009, Vol. 8 Issue 3, p592009

Identification of Bioactive Peptides from Cereal Storage Proteins and Their Potential Role in Prevention of Chronic Diseases

Ariel Cavazos and Elvira Gonzalez de Mejia

Comprehensive Reviews in Food Science and Food Safety Volume 12, Issue 4, pages 364–380, July 20132013

An investigation into the biological activity of the selected histidine-containing diketopiperazines cyclo(His-Phe) and cyclo(His-Tyr).

McCleland K, Milne PJ, Lucieto FR, Frost C, Brauns SC, Van de Venter M, Du Plessis J, Dyason K

J Pharm Pharmacol2004PMID 15324483

A novel series of dipeptide derivatives containing indole-3-carboxylic acid conjugates as potential antimicrobial agents: the design, solid phase peptide synthesis, in vitro biological evaluation, and molecular docking study.

Tivari SR, Kokate SV, Delgado-Alvarado E, Gayke MS, Kotmale A, Patel H, Ahmad I, Sobhia EM, Kumar SG, Lara BG, Jain VD, Jadeja Y

RSC Adv2023PMID 37583660

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:10.991164+00:00

Modification summary

No structured modification annotations are available for this record.

Source metadata
[
  {
    "source_db": "ahtpdb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dbaasp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dramp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "plantpepdb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "satpdb",
    "organism_name": "Unknown"
  }
]
Structure metadata
{
  "source_db": "satpdb",
  "dssp_states": "CC"
}