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PEPDIA-INT-002975

Gold

(KW)3

Quality

Source DBs

Activities

Source refs

Literature

Patents

Integrated record

Sequence and molecular profile

KWKWKW

Indexed sequence6 aa

1KWKWKW

Length

Molecular weight

961.18 Da

Formula

C51H68N12O7

Structure type

Linear

Synthesis

Synthetic

Chirality

Mixed

Family

Gene

Residue composition

Physicochemical profile

Hydrophobic3

Membrane affinity proxy

Polar0

Solubility proxy

Charged3

Net charge proxy +3

Aromatic3

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

961.1619 Da

Molecular formula

C51H68N12O7

Theoretical pI

10.3021

Net charge at pH 7

2.7571

GRAVY

-2.4

Instability index

8.3333

Aromaticity

0.5

Topological polar surface area

334.25 Å²

cLogP

2.3813

Hydrogen-bond donors

Hydrogen-bond acceptors

Rotatable bonds

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

KWKWKW

HELM 2.0

validated simple linear

PEPTIDE1{K.W.K.W.K.W}$$$$V2.0

Canonical SMILES

validated

NCCCCC(N)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(CCCCN)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(CCCCN)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)O

Isomeric SMILES

validated

NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.

Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.

Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-002975,
  title = {(KW)3},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-002975},
  note = {Accessed from local PepDiana development build}
}

APA-style note

(KW)3. (2026). PepDiana record PEPDIA-INT-002975. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-002975

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (67 records)

Stable record	Activity	Subtype	Value	Target	Assay method	Source
CTPDB_P002975_ACT_camp_0000	Antimicrobial	Antifungal	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ11917camp / linked
CTPDB_P002975_ACT_cancerppd_0001	Anticancer	Anticancer	Not available in the current structured import	Unknown	MTT/MTS assay	4618cancerppd / linked
CTPDB_P002975_ACT_cancerppd_0002	Anticancer	Anticancer	Not available in the current structured import	Unknown	MTT/MTS assay	4619cancerppd / linked
CTPDB_P002975_ACT_dbaasp_0050	Antimicrobial	-	5 µg/ml	Candida albicans ATCC 10231	Not reported by source	DBAASPS_22242_chain0dbaasp / linked
CTPDB_P002975_ACT_dbaasp_0051	Antimicrobial	-	5 µg/ml	Candida albicans ATCC 10231	Not reported by source	DBAASPS_22242_chain0dbaasp / linked
CTPDB_P002975_ACT_dbaasp_0052	Antimicrobial	-	15 µg/ml	Candida albicans ATCC MYA-573	Not reported by source	DBAASPS_22242_chain0dbaasp / linked
CTPDB_P002975_ACT_dbaasp_0053	Antimicrobial	-	15 µg/ml	Candida albicans ATCC MYA-573	Not reported by source	DBAASPS_22242_chain0dbaasp / linked
CTPDB_P002975_ACT_dbaasp_0003	Antimicrobial	-	50 µM	Escherichia coli KCTC 1682	Not reported by source	DBAASPS_4494_chain0dbaasp / linked
CTPDB_P002975_ACT_dbaasp_0004	Antimicrobial	-	200 µM	Escherichia coli KCTC 1682	Not reported by source	DBAASPS_4494_chain0dbaasp / linked
CTPDB_P002975_ACT_dbaasp_0005	Antimicrobial	-	3.12 µM	Salmonella typhimurium KCTC 1926	Not reported by source	DBAASPS_4494_chain0dbaasp / linked
CTPDB_P002975_ACT_dbaasp_0006	Antimicrobial	-	6.25 µM	Salmonella typhimurium KCTC 1926	Not reported by source	DBAASPS_4494_chain0dbaasp / linked
CTPDB_P002975_ACT_dbaasp_0007	Antimicrobial	-	12.5 µM	Pseudomonas aeruginosa KCTC 1637	Not reported by source	DBAASPS_4494_chain0dbaasp / linked
CTPDB_P002975_ACT_dbaasp_0008	Antimicrobial	-	25 µM	Pseudomonas aeruginosa KCTC 1637	Not reported by source	DBAASPS_4494_chain0dbaasp / linked
CTPDB_P002975_ACT_dbaasp_0009	Antimicrobial	-	50 µM	Staphylococcus aureus KCTC 1621	Not reported by source	DBAASPS_4494_chain0dbaasp / linked
CTPDB_P002975_ACT_dbaasp_0010	Antimicrobial	-	200 µM	Staphylococcus aureus KCTC 1621	Not reported by source	DBAASPS_4494_chain0dbaasp / linked
CTPDB_P002975_ACT_dbaasp_0011	Antimicrobial	-	100 µM	Bacillus subtilis KCTC 1918	Not reported by source	DBAASPS_4494_chain0dbaasp / linked
CTPDB_P002975_ACT_dbaasp_0012	Antimicrobial	-	200 µM	Bacillus subtilis KCTC 1918	Not reported by source	DBAASPS_4494_chain0dbaasp / linked
CTPDB_P002975_ACT_dbaasp_0013	Antimicrobial	-	12.5 µM	Listeria monocytogenes KCTC 3710	Not reported by source	DBAASPS_4494_chain0dbaasp / linked
CTPDB_P002975_ACT_dbaasp_0014	Antimicrobial	-	25 µM	Listeria monocytogenes KCTC 3710	Not reported by source	DBAASPS_4494_chain0dbaasp / linked
CTPDB_P002975_ACT_dbaasp_0015	Antimicrobial	-	25 µM	Escherichia coli CCARM 1229	Not reported by source	DBAASPS_4494_chain0dbaasp / linked
CTPDB_P002975_ACT_dbaasp_0016	Antimicrobial	-	100 µM	Escherichia coli CCARM 1229	Not reported by source	DBAASPS_4494_chain0dbaasp / linked
CTPDB_P002975_ACT_dbaasp_0017	Antimicrobial	-	50 µM	Escherichia coli CCARM 1238	Not reported by source	DBAASPS_4494_chain0dbaasp / linked
CTPDB_P002975_ACT_dbaasp_0018	Antimicrobial	-	200 µM	Escherichia coli CCARM 1238	Not reported by source	DBAASPS_4494_chain0dbaasp / linked
CTPDB_P002975_ACT_dbaasp_0019	Antimicrobial	-	50 µM	Salmonella typhimurium CCARM 8007	Not reported by source	DBAASPS_4494_chain0dbaasp / linked
CTPDB_P002975_ACT_dbaasp_0020	Antimicrobial	-	200 µM	Salmonella typhimurium CCARM 8007	Not reported by source	DBAASPS_4494_chain0dbaasp / linked
CTPDB_P002975_ACT_dbaasp_0021	Antimicrobial	-	50 µM	Salmonella typhimurium CCARM 8009	Not reported by source	DBAASPS_4494_chain0dbaasp / linked
CTPDB_P002975_ACT_dbaasp_0022	Antimicrobial	-	200 µM	Salmonella typhimurium CCARM 8009	Not reported by source	DBAASPS_4494_chain0dbaasp / linked
CTPDB_P002975_ACT_dbaasp_0023	Antimicrobial	-	50 µM	Salmonella typhimurium CCARM 8013	Not reported by source	DBAASPS_4494_chain0dbaasp / linked
CTPDB_P002975_ACT_dbaasp_0024	Antimicrobial	-	200 µM	Salmonella typhimurium CCARM 8013	Not reported by source	DBAASPS_4494_chain0dbaasp / linked
CTPDB_P002975_ACT_dbaasp_0025	Antimicrobial	-	50 µM	Staphylococcus aureus CCARM 3089	Not reported by source	DBAASPS_4494_chain0dbaasp / linked
CTPDB_P002975_ACT_dbaasp_0026	Antimicrobial	-	200 µM	Staphylococcus aureus CCARM 3089	Not reported by source	DBAASPS_4494_chain0dbaasp / linked
CTPDB_P002975_ACT_dbaasp_0027	Antimicrobial	-	50 µM	Staphylococcus aureus CCARM 3090	Not reported by source	DBAASPS_4494_chain0dbaasp / linked
CTPDB_P002975_ACT_dbaasp_0028	Antimicrobial	-	200 µM	Staphylococcus aureus CCARM 3090	Not reported by source	DBAASPS_4494_chain0dbaasp / linked
CTPDB_P002975_ACT_dbaasp_0029	Antimicrobial	-	50 µM	Staphylococcus aureus CCARM 3108	Not reported by source	DBAASPS_4494_chain0dbaasp / linked
CTPDB_P002975_ACT_dbaasp_0030	Antimicrobial	-	200 µM	Staphylococcus aureus CCARM 3108	Not reported by source	DBAASPS_4494_chain0dbaasp / linked
CTPDB_P002975_ACT_dbaasp_0031	Antimicrobial	-	50 µM	Staphylococcus aureus CCARM 3114	Not reported by source	DBAASPS_4494_chain0dbaasp / linked
CTPDB_P002975_ACT_dbaasp_0032	Antimicrobial	-	200 µM	Staphylococcus aureus CCARM 3114	Not reported by source	DBAASPS_4494_chain0dbaasp / linked
CTPDB_P002975_ACT_dbaasp_0033	Antimicrobial	-	50 µM	Staphylococcus aureus CCARM 3126	Not reported by source	DBAASPS_4494_chain0dbaasp / linked
CTPDB_P002975_ACT_dbaasp_0034	Antimicrobial	-	200 µM	Staphylococcus aureus CCARM 3126	Not reported by source	DBAASPS_4494_chain0dbaasp / linked
CTPDB_P002975_ACT_dbaasp_0035	Antimicrobial	-	16 µM	Candida albicans KCTC 7270	Not reported by source	DBAASPS_4494_chain0dbaasp / linked
CTPDB_P002975_ACT_dbaasp_0036	Antimicrobial	-	8 µM	Trichosporon beigelii KCTC 7707	Not reported by source	DBAASPS_4494_chain0dbaasp / linked
CTPDB_P002975_ACT_dbaasp_0037	Antimicrobial	-	16 µM	Candida albicans CCARM 14001	Not reported by source	DBAASPS_4494_chain0dbaasp / linked
CTPDB_P002975_ACT_dbaasp_0038	Antimicrobial	-	16 µM	Candida albicans CCARM 14007	Not reported by source	DBAASPS_4494_chain0dbaasp / linked
CTPDB_P002975_ACT_dbaasp_0039	Antimicrobial	-	16 µM	Candida albicans CCARM 14020	Not reported by source	DBAASPS_4494_chain0dbaasp / linked
CTPDB_P002975_ACT_dbaasp_0040	Antimicrobial	-	>100 µM	Escherichia coli DSM 30083	Not reported by source	DBAASPS_4494_chain0dbaasp / linked
CTPDB_P002975_ACT_dbaasp_0041	Antimicrobial	-	>100 µM	Acinetobacter baumannii DSM 30007	Not reported by source	DBAASPS_4494_chain0dbaasp / linked
CTPDB_P002975_ACT_dbaasp_0042	Antimicrobial	-	>100 µM	Pseudomonas aeruginosa DSM 50071	Not reported by source	DBAASPS_4494_chain0dbaasp / linked
CTPDB_P002975_ACT_dbaasp_0043	Antimicrobial	-	5.7-11 µM	Bacillus subtilis DSM 402	Not reported by source	DBAASPS_4494_chain0dbaasp / linked
CTPDB_P002975_ACT_dbaasp_0044	Antimicrobial	-	>100 µM	Staphylococcus aureus DSM 20231	Not reported by source	DBAASPS_4494_chain0dbaasp / linked
CTPDB_P002975_ACT_dbaasp_0045	Antimicrobial	-	>100 µM	Staphylococcus aureus ATCC 43300	Not reported by source	DBAASPS_4494_chain0dbaasp / linked
CTPDB_P002975_ACT_dbaasp_0046	Antimicrobial	-	>100 µM	Staphylococcus aureus USA 100	Not reported by source	DBAASPS_9580_chain0dbaasp / linked
CTPDB_P002975_ACT_dbaasp_0047	Antimicrobial	-	>100 µM	Staphylococcus aureus USA 300	Not reported by source	DBAASPS_9580_chain0dbaasp / linked
CTPDB_P002975_ACT_dbaasp_0048	Antimicrobial	-	>100 µM	Pseudomonas aeruginosa ATCC 9027	Not reported by source	DBAASPS_9580_chain0dbaasp / linked
CTPDB_P002975_ACT_dbaasp_0049	Antimicrobial	-	>100 µM	Candida albicans ATCC 90028	Not reported by source	DBAASPS_9580_chain0dbaasp / linked
CTPDB_P002975_ACT_dramp_0054	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	DRAMP03913dramp / linked
CTPDB_P002975_ACT_dramp_0055	Antimicrobial	Antifungal	Not available in the current structured import	Unknown	Not reported by source	DRAMP03913dramp / linked
CTPDB_P002975_ACT_dramp_0056	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	DRAMP27638dramp / linked
CTPDB_P002975_ACT_dramp_0057	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	DRAMP27638dramp / linked
CTPDB_P002975_ACT_dramp_0058	Antimicrobial	Antifungal	Not available in the current structured import	Unknown	Not reported by source	DRAMP27638dramp / linked
CTPDB_P002975_ACT_hemolytik_0059	Toxicity	Hemolytic	200.0 µM	Erythrocytes	Not reported by source	2604hemolytik / linked
CTPDB_P002975_ACT_hemolytik_0060	Toxicity	Hemolytic	400.0 µM	Erythrocytes	Not reported by source	3018hemolytik / linked
CTPDB_P002975_ACT_hemolytik_0061	Toxicity	Hemolytic	600.0 µM	Erythrocytes	Not reported by source	3019hemolytik / linked
CTPDB_P002975_ACT_satpdb_0062	Anticancer	-	Not available in the current structured import	Unknown	Not reported by source	satpdb12379satpdb / linked
CTPDB_P002975_ACT_satpdb_0063	Toxicity	General Toxic	Not available in the current structured import	Unknown	Not reported by source	satpdb21462satpdb / linked
CTPDB_P002975_ACT_satpdb_0064	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	satpdb21462satpdb / linked
CTPDB_P002975_ACT_satpdb_0065	Toxicity	General Toxic	Not available in the current structured import	Unknown	Not reported by source	satpdb24601satpdb / linked
CTPDB_P002975_ACT_satpdb_0066	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	satpdb24601satpdb / linked

Provenance

Source database records (14)

camp

CAMPSQ11917

Raw sequence

KWKWKW

cancerppd

4618

Raw sequence

KWKWKW

cancerppd

4619

Raw sequence

KWKWKW

dbaasp

DBAASPS_4494_chain0

Raw sequence

KWKWKW

dbaasp

DBAASPS_9580_chain0

Raw sequence

KWKWKW

dbaasp

DBAASPS_22242_chain0

Raw sequence

KWKWKW

dramp

DRAMP03913

Raw sequence

KWKWKW

dramp

DRAMP27638

Raw sequence

KWKWKW

hemolytik

2604

Raw sequence

KWKWKW

hemolytik

3018

Raw sequence

KWKWKW

hemolytik

3019

Raw sequence

KWKWKW

satpdb

satpdb12379

Raw sequence

KWKWKW

satpdb

satpdb21462

Raw sequence

KWKWKW

satpdb

satpdb24601

Raw sequence

KWKWKW

Citation trail

Literature (8 records)

-

--PMID 28105725

-

--PMID 20964334

Effect of repetitive lysine-tryptophan motifs on the bactericidal activity of antimicrobial peptides.

Gopal R, Seo C, Song P, Park Y

Amino Acids2013PMID 22914980

Effect of repetitive lysine-tryptophan motifs on the bactericidal activity of antimicrobial peptides.

Gopal R, Seo C, Song P, Park Y

Amino Acids2013PMID 21462284

Effect of repetitive lysine-tryptophan motifs on the bactericidal activity of antimicrobial peptides.

Gopal R, Seo C, Song P, Park Y

Amino Acids2013PMID 23209509

[{"citation": "", "authors": [{"name": "Lau QY", "description": ""}, {"name": "Choo XY", "description": ""}, {"name": "Lim ZX", "description": ""}, {"name": "Kong X", "description": ""}, {"name": "Ng FM", "description": ""}, {"name": "Ang M", "description": ""}, {"name": "Hill J", "description": ""}, {"name": "Chia CS", "description": ""}], "journal": {"name": "Int J Pept Res Ther", "description": "International Journal of Peptide Research and Therapeutics"}, "year": 2015, "volume": "21", "pages

[{"citation": "", "authors": [{"name": "Lau QY", "description": ""}, {"name": "Choo XY", "description": ""}, {"name": "Lim ZX", "description": ""}, {"name": "Kong X", "description": ""}, {"name": "Ng FM", "description": ""}, {"name": "Ang M", "description": ""}, {"name": "Hill J", "description": ""}, {"name": "Chia CS", "description": ""}], "journal": {"name": "Int J Pept Res Ther", "description": "International Journal of Peptide Research and Therapeutics"}, "year": 2015, "volume": "21", "pages

A pilot study on ultrashort peptide with fluconazole: A promising novel anticandidal combination

Darwish RM, Salama AH

Vet World2023PMID 37577210

Antifungal Activity of (KW)n or (RW)n Peptide against Fusarium solani and Fusarium oxysporum.

Gopal R, Na H, Seo CH, Park Y.

Int J Mol Sci2012PMID 23203110

IP evidence

Patents (1)

US 10301354

dramp

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:15.023171+00:00

Modification summary

No structured modification annotations are available for this record.

ADMET

{
  "toxicity": [
    {
      "unit": "µM",
      "value": "350",
      "source_db": "dbaasp",
      "assay_method": "10% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Human erythrocytes"
    },
    {
      "unit": "µM",
      "value": "100",
      "source_db": "dbaasp",
      "assay_method": "3% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Human erythrocytes"
    }
  ]
}

Source metadata

[
  {
    "source_db": "camp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "cancerppd",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dbaasp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dramp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "hemolytik",
    "organism_name": "Unknown"
  },
  {
    "source_db": "satpdb",
    "organism_name": "Unknown"
  }
]

Structure metadata

{
  "source_db": "satpdb",
  "dssp_states": "CCCSCC"
}