Record tools

Copy identifiers or export this single peptide record for a local research note.

PEPDIA-INT-002864

Gold

Exendin-4

Quality

Source DBs

Activities

Source refs

Literature

Patents

Integrated record

Sequence and molecular profile

HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS

Indexed sequence39 aa

1HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS

Length

Molecular weight

4187.62 Da

Formula

C184H281N49O61S

Structure type

Linear

Synthesis

Chirality

Family

Gene

Residue composition

Physicochemical profile

Hydrophobic11

Membrane affinity proxy

Polar9

Solubility proxy

Charged10

Net charge proxy -2

Aromatic4

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

4187.5564 Da

Molecular formula

C184H281N49O61S

Theoretical pI

4.6991

Net charge at pH 7

-3.1396

GRAVY

-0.6923

Instability index

64.0821

Aromaticity

0.0769

Topological polar surface area

1743.96 Å²

cLogP

-20.005

Hydrogen-bond donors

Hydrogen-bond acceptors

Rotatable bonds

134

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS

HELM 2.0

validated simple linear

PEPTIDE1{H.G.E.G.T.F.T.S.D.L.S.K.Q.M.E.E.E.A.V.R.L.F.I.E.W.L.K.N.G.G.P.S.S.G.A.P.P.P.S}$$$$V2.0

Canonical SMILES

validated

CCC(C)C(NC(=O)C(Cc1ccccc1)NC(=O)C(CC(C)C)NC(=O)C(CCCNC(=N)N)NC(=O)C(NC(=O)C(C)NC(=O)C(CCC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(CCSC)NC(=O)C(CCC(N)=O)NC(=O)C(CCCCN)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CC(=O)O)NC(=O)C(CO)NC(=O)C(NC(=O)C(Cc1ccccc1)NC(=O)C(NC(=O)CNC(=O)C(CCC(=O)O)NC(=O)CNC(=O)C(N)Cc1c[nH]cn1)C(C)O)C(C)O)C(C)C)C(=O)NC(CCC(=O)O)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(CC(C)C)C(=O)NC(CCCCN)C(=O)NC(CC(N)=O)C(=O)NCC(=O)NCC(=O)N1CCCC1C(=O)NC(CO)C(=O)NC(CO)C(=O)NCC(=O)NC(C)C(=O)N1CCCC1C(=O)N1CCCC1C(=O)N1CCCC1C(=O)NC(CO)C(=O)O

Isomeric SMILES

validated

CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)O

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.

Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.

Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-002864,
  title = {Exendin-4},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-002864},
  note = {Accessed from local PepDiana development build}
}

APA-style note

Exendin-4. (2026). PepDiana record PEPDIA-INT-002864. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-002864

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (4 records)

Stable record	Activity	Subtype	Value	Target	Assay method	Source
CTPDB_P002864_ACT_satpdb_0000	Cell-Penetrating	Drug Delivery	Not available in the current structured import	Unknown	Not reported by source	satpdb16214satpdb / linked
CTPDB_P002864_ACT_satpdb_0001	Cell-Penetrating	Drug Delivery	Not available in the current structured import	Unknown	Not reported by source	satpdb25171satpdb / linked
CTPDB_P002864_ACT_thpdb_0002	Clinical / Approved Drug	General Therapeutic	Not available in the current structured import	Unknown	Not reported by source	Th1098_10505_rec0thpdb / unavailable
CTPDB_P002864_ACT_thpdb_0003	Clinical / Approved Drug	General Therapeutic	Not available in the current structured import	Unknown	Not reported by source	Th1098_10506_rec1thpdb / unavailable

Provenance

Source database records (16)

b3pdb

b3pdb_0456

Raw sequence

HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS

b3pdb

b3pdb_0457

Raw sequence

HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS

b3pdb

b3pdb_0458

Raw sequence

HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS

b3pdb

b3pdb_0459

Raw sequence

HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS

b3pdb

b3pdb_0460

Raw sequence

HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS

b3pdb

b3pdb_0461

Raw sequence

HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS

b3pdb

b3pdb_0462

Raw sequence

HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS

b3pdb

b3pdb_0463

Raw sequence

HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS

b3pdb

b3pdb_0464

Raw sequence

HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS

b3pdb

b3pdb_0465

Raw sequence

HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS

b3pdb

b3pdb_0466

Raw sequence

HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS

b3pdb

b3pdb_0467

Raw sequence

HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS

satpdb

satpdb16214

Raw sequence

HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS

satpdb

satpdb25171

Raw sequence

HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS

thpdb

Th1098_10505_rec0

Raw sequence

HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS

thpdb

Th1098_10506_rec1

Raw sequence

HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS

Citation trail

Literature (1 records)

-

--PMID 12629557

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:13.664756+00:00

Modification summary

No structured modification annotations are available for this record.

ADMET

{
  "toxicity": [
    {
      "source_db": "thpdb",
      "assay_method": "In animal studies, exenatide was associated with fetal deformities of ribs and vertebrae as well as slowed growthLabel. In humans, uncontrolled hyperglycemia can be associated with an up to 25% risk o",
      "toxicity_type": "Toxicity"
    },
    {
      "source_db": "thpdb",
      "assay_method": "In animal studies, exenatide was associated with fetal deformities of ribs and vertebrae as well as slowed growthLabel. In humans, uncontrolled hyperglycemia can be associated with an up to 25% risk o",
      "toxicity_type": "Toxicity"
    }
  ]
}

Source metadata

[
  {
    "source_db": "b3pdb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "satpdb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "thpdb",
    "organism_name": "Unknown"
  }
]

Structure metadata

{
  "source_db": "satpdb",
  "dssp_states": "CCCCTTHHHHHHHHHHHHHHHHHHHHHTTGGGSSSCCCC"
}