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PEPDIA-INT-001593

Silver

Kallidin

Quality

Source DBs

Activities

Source refs

Literature

Patents

Integrated record

Sequence and molecular profile

KRPPGFSPFR

Indexed sequence10 aa

1KRPPGFSPFR

Length

Molecular weight

1188.40 Da

Formula

C56H85N17O12

Structure type

Linear

Synthesis

Chirality

Family

Gene

Residue composition

Physicochemical profile

Hydrophobic2

Membrane affinity proxy

Polar1

Solubility proxy

Charged3

Net charge proxy +3

Aromatic2

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

1188.3808 Da

Molecular formula

C56H85N17O12

Theoretical pI

Net charge at pH 7

2.7591

GRAVY

-1.33

Instability index

143.32

Aromaticity

0.2

Topological polar surface area

468.9 Å²

cLogP

-3.9553

Hydrogen-bond donors

Hydrogen-bond acceptors

Rotatable bonds

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

KRPPGFSPFR

HELM 2.0

validated simple linear

PEPTIDE1{K.R.P.P.G.F.S.P.F.R}$$$$V2.0

Canonical SMILES

validated

N=C(N)NCCCC(NC(=O)C(Cc1ccccc1)NC(=O)C1CCCN1C(=O)C(CO)NC(=O)C(Cc1ccccc1)NC(=O)CNC(=O)C1CCCN1C(=O)C1CCCN1C(=O)C(CCCNC(=N)N)NC(=O)C(N)CCCCN)C(=O)O

Isomeric SMILES

validated

N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCCN)C(=O)O

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.

Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.

Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-001593,
  title = {Kallidin},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-001593},
  note = {Accessed from local PepDiana development build}
}

APA-style note

Kallidin. (2026). PepDiana record PEPDIA-INT-001593. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-001593

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (8 records)

Stable record	Activity	Subtype	Value	Target	Assay method	Source
CTPDB_P001593_ACT_satpdb_0000	Bioregulatory	Cell-Cell Communication	Not available in the current structured import	Unknown	Not reported by source	satpdb10273satpdb / linked
CTPDB_P001593_ACT_topicalpdb_0001	Wound Healing	Skin Penetrating	Not available in the current structured import	Unknown	Algesic response: ~15(VAS value), the intensity of the sensation experienced with a single dose of capsaicin was considered the maximum value (i.e. 100) on the analogue scale, and all successive responses were scored in relation to this value. Maximal painful response was attained 1-2 minutes after drug administration and faded after 5 minutes.; Painful sensation assessed in a visual analogue scale(VAS); in vivo	1259topicalpdb / linked
CTPDB_P001593_ACT_topicalpdb_0002	Wound Healing	Skin Penetrating	Not available in the current structured import	Unknown	Algesic response: ~22(VAS value), the intensity of the sensation experienced with a single dose of capsaicin was considered the maximum value (i.e. 100) on the analogue scale, and all successive responses were scored in relation to this value. Maximal painful response was attained 1-2 minutes after drug administration and faded after 5 minutes.; Painful sensation assessed in a visual analogue scale(VAS); in vivo	1260topicalpdb / linked
CTPDB_P001593_ACT_topicalpdb_0003	Wound Healing	Skin Penetrating	Not available in the current structured import	Unknown	Pain response obtained in nostrils after capsaicin vehicle pretreatment: ~15.3(VAS value), the intensity of the sensation experienced with a single dose of capsaicin was considered the maximum value (i.e. 100) on the analogue scale, and all successive responses were scored in relation to this value.; Painful sensation assessed in a visual analogue scale(VAS); in vivo	1261topicalpdb / linked
CTPDB_P001593_ACT_topicalpdb_0004	Wound Healing	Skin Penetrating	Not available in the current structured import	Unknown	Pain response obtained in nostrils after capsaicin pretreatment((50 nmol in 50 µl, everyday for 5-7 days): ~10.7(VAS value), the intensity of the sensation experienced with a single dose of capsaicin was considered the maximum value (i.e. 100) on the analogue scale, and all successive responses were scored in relation to this value.; Painful sensation assessed in a visual analogue scale(VAS); in vivo	1262topicalpdb / linked
CTPDB_P001593_ACT_topicalpdb_0005	Wound Healing	Skin Penetrating	Not available in the current structured import	Unknown	Pain response obtained in nostrils after capsaicin vehicle pretreatment: ~22(VAS value), the intensity of the sensation experienced with a single dose of capsaicin was considered the maximum value (i.e. 100) on the analogue scale, and all successive responses were scored in relation to this value.; Painful sensation assessed in a visual analogue scale(VAS); in vivo	1263topicalpdb / linked
CTPDB_P001593_ACT_topicalpdb_0006	Wound Healing	Skin Penetrating	Not available in the current structured import	Unknown	Pain response obtained in nostrils after capsaicin pretreatment((50 nmol in 50 µl, everyday for 5-7 days): ~20(VAS value), the intensity of the sensation experienced with a single dose of capsaicin was considered the maximum value (i.e. 100) on the analogue scale, and all successive responses were scored in relation to this value.; Painful sensation assessed in a visual analogue scale(VAS); in vivo	1264topicalpdb / linked
CTPDB_P001593_ACT_topicalpdb_0007	Wound Healing	Skin Penetrating	Not available in the current structured import	Unknown	The maximal painful response was attained 1-2 min after drug administration and faded after 5 min; Pain response evaluated by a visual analogue scale; in vivo	1395topicalpdb / linked

Provenance

Source database records (8)

satpdb

satpdb10273

Raw sequence

KRPPGFSPFR

topicalpdb

1259

Raw sequence

KRPPGFSPFR

topicalpdb

1260

Raw sequence

KRPPGFSPFR

topicalpdb

1261

Raw sequence

KRPPGFSPFR

topicalpdb

1262

Raw sequence

KRPPGFSPFR

topicalpdb

1263

Raw sequence

KRPPGFSPFR

topicalpdb

1264

Raw sequence

KRPPGFSPFR

topicalpdb

1395

Raw sequence

KRPPGFSPFR

Citation trail

Literature (1 records)

-

--PMID 8443036

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:21.764269+00:00

Modification summary

No structured modification annotations are available for this record.

Source metadata

[
  {
    "source_db": "satpdb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "topicalpdb",
    "organism_name": "Unknown"
  }
]

Structure metadata

{
  "source_db": "satpdb",
  "dssp_states": "CCCSCSSTTC"
}