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PEPDIA-INT-000378

Gold

Unnamed peptide

Quality

Source DBs

Activities

Source refs

Literature

Patents

Integrated record

Sequence and molecular profile

WLAHK

Indexed sequence5 aa

1WLAHK

Length

Molecular weight

653.78 Da

Formula

C32H47N9O6

Structure type

Linear

Synthesis

Chirality

Family

Gene

Residue composition

Physicochemical profile

Hydrophobic3

Membrane affinity proxy

Polar0

Solubility proxy

Charged2

Net charge proxy +2

Aromatic2

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

653.7723 Da

Molecular formula

C32H47N9O6

Theoretical pI

8.7572

Net charge at pH 7

0.8463

GRAVY

-0.48

Instability index

63.06

Aromaticity

0.2

Topological polar surface area

250.21 Å²

cLogP

0.2223

Hydrogen-bond donors

Hydrogen-bond acceptors

Rotatable bonds

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

WLAHK

HELM 2.0

validated simple linear

PEPTIDE1{W.L.A.H.K}$$$$V2.0

Canonical SMILES

validated

CC(C)CC(NC(=O)C(N)Cc1c[nH]c2ccccc12)C(=O)NC(C)C(=O)NC(Cc1c[nH]cn1)C(=O)NC(CCCCN)C(=O)O

Isomeric SMILES

validated

CC(C)C[C@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCCN)C(=O)O

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.

Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.

Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-000378,
  title = {Unnamed peptide},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-000378},
  note = {Accessed from local PepDiana development build}
}

APA-style note

Unnamed peptide. (2026). PepDiana record PEPDIA-INT-000378. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-000378

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (9 records)

Stable record	Activity	Subtype	Value	Target	Assay method	Source
CTPDB_P000378_ACT_ahtpdb_0000	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Not reported by source	1205ahtpdb / linked
CTPDB_P000378_ACT_ahtpdb_0001	Metabolic/Cardiovascular	ACE Inhibitor	77.0 µM	Unknown	Vermeirssen et al.	1305ahtpdb / linked
CTPDB_P000378_ACT_ahtpdb_0002	Metabolic/Cardiovascular	ACE Inhibitor	77.0 µM	Unknown	Vermeirssen et al.	1332ahtpdb / linked
CTPDB_P000378_ACT_ahtpdb_0003	Metabolic/Cardiovascular	ACE Inhibitor	176.4 µM	Unknown	Not reported by source	2460ahtpdb / linked
CTPDB_P000378_ACT_ahtpdb_0004	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Not reported by source	3305ahtpdb / linked
CTPDB_P000378_ACT_ahtpdb_0005	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Holmquist et al. (1979)	5944ahtpdb / linked
CTPDB_P000378_ACT_ahtpdb_0006	Metabolic/Cardiovascular	ACE Inhibitor	77.0 µM	Unknown	Not reported by source	6478ahtpdb / linked
CTPDB_P000378_ACT_fermfoodb_0007	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Not reported by source	FermFooDB_Whey_FMDB337fermfoodb / linked
CTPDB_P000378_ACT_satpdb_0008	Metabolic/Cardiovascular	Antihypertensive	Not available for this observation	Unknown	Not reported by source	satpdb18886satpdb / linked

Provenance

Source database records (9)

ahtpdb

2460

Raw sequence

WLAHK

ahtpdb

1205

Raw sequence

WLAHK

ahtpdb

1305

Raw sequence

WLAHK

ahtpdb

1332

Raw sequence

WLAHK

ahtpdb

6478

Raw sequence

WLAHK

ahtpdb

5944

Raw sequence

WLAHK

ahtpdb

3305

Raw sequence

WLAHK

fermfoodb

FermFooDB_Whey_FMDB337

Raw sequence

WLAHK

satpdb

satpdb18886

Raw sequence

WLAHK

Citation trail

Literature (7 records)

A new QSAR model, for angiotensin I-converting enzyme inhibitory oligopeptides.

Sagardia I1, Roa-Ureta RH, Bald C.

Food Chem. 2013 Feb 15;136(3-4):1370-6.2013PMID 23194537

MILK PROTEINS AS PRECURSORS OF BIOACTIVE PEPTIDES

Marta Dziuba, Bart?omiej Dziuba, Anna Iwaniak

Acta Sci. Pol.,Technol. Aliment. 8(1) 2009,71-902009

Whey Proteins as Source of Bioactive Peptides Against Hypertension

Ta?nia G. Tavares and F. Xavier Malcata

Bioactive Food Peptides in Health and Disease Edited by Blanca Hernandez-Ledesma and Chia-Chien Hsieh, ISBN 978-953-51-0964-8, 276 pages2013

Angiotensin I-converting enzyme inhibitory properties of whey protein digests: concentration and characterization of active peptides.

Pihlanto-Leppälä A et al.

J Dairy Res. 2000 Feb;67(1):53-64.2000PMID 10717843

Preparation of angiotensin-I-converting enzyme inhibitory hydrolysates from unsupplemented caprine whey fermentation by various cheese microflora

Didelot, S. et al.,

Int Dairy J 16 p.976-9822006

Animal and Plant Proteins as Precursors of Peptides with ACE Inhibitory Activity – An in silico Strategy of Protein Evaluation

Anna Iwaniak and Jerzy Dziuba

Food Technol. Biotechnol. 47 (4) 441–449 (2009)2009

-

--PMID 16476172

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:11.113046+00:00

Modification summary

No structured modification annotations are available for this record.

Source metadata

[
  {
    "source_db": "ahtpdb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "fermfoodb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "satpdb",
    "organism_name": "Unknown"
  }
]

Structure metadata

{
  "source_db": "satpdb",
  "dssp_states": "CCTTC"
}