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PEPDIA-INT-067228

Gold

Unnamed peptide

Quality

Source DBs

Activities

Source refs

Literature

Patents

Integrated record

Sequence and molecular profile

YPFPGPIPN

Indexed sequence9 aa

1YPFPGPIPN

Length

Molecular weight

1001.15 Da

Formula

C50H68N10O12

Structure type

Linear

Synthesis

Chirality

Family

Gene

Residue composition

Physicochemical profile

Hydrophobic3

Membrane affinity proxy

Polar1

Solubility proxy

Charged0

Net charge proxy +0

Aromatic2

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

1001.1346 Da

Molecular formula

C50H68N10O12

Theoretical pI

5.5243

Net charge at pH 7

-0.2409

GRAVY

-0.4778

Instability index

62.2

Aromaticity

0.2222

Topological polar surface area

324.28 Å²

cLogP

-0.9546

Hydrogen-bond donors

Hydrogen-bond acceptors

Rotatable bonds

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

YPFPGPIPN

HELM 2.0

validated simple linear

PEPTIDE1{Y.P.F.P.G.P.I.P.N}$$$$V2.0

Canonical SMILES

validated

CCC(C)C(NC(=O)C1CCCN1C(=O)CNC(=O)C1CCCN1C(=O)C(Cc1ccccc1)NC(=O)C1CCCN1C(=O)C(N)Cc1ccc(O)cc1)C(=O)N1CCCC1C(=O)NC(CC(N)=O)C(=O)O

Isomeric SMILES

validated

CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)O

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.

Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.

Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-067228,
  title = {Unnamed peptide},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-067228},
  note = {Accessed from local PepDiana development build}
}

APA-style note

Unnamed peptide. (2026). PepDiana record PEPDIA-INT-067228. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-067228

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (13 records)

Stable record	Activity	Subtype	Value	Target	Assay method	Source
CTPDB_P067228_ACT_ahtpdb_0002	Metabolic/Cardiovascular	ACE Inhibitor	14.8 µM	Unknown	Cushman and Cheung (1971)	1709ahtpdb / linked
CTPDB_P067228_ACT_ahtpdb_0003	Metabolic/Cardiovascular	ACE Inhibitor	15.0 µM	Unknown	Not reported by source	2373ahtpdb / linked
CTPDB_P067228_ACT_ahtpdb_0004	Metabolic/Cardiovascular	ACE Inhibitor	14.8 µM	Unknown	Abubakar et al.	2762ahtpdb / linked
CTPDB_P067228_ACT_ahtpdb_0005	Metabolic/Cardiovascular	ACE Inhibitor	14.8 µM	Unknown	Abubakar et al.	3619ahtpdb / linked
CTPDB_P067228_ACT_ahtpdb_0000	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Abubakar et al.	4193ahtpdb / linked
CTPDB_P067228_ACT_ahtpdb_0001	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Not reported by source	4609ahtpdb / linked
CTPDB_P067228_ACT_ahtpdb_0006	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Not reported by source	5037ahtpdb / linked
CTPDB_P067228_ACT_ahtpdb_0007	Metabolic/Cardiovascular	ACE Inhibitor	14.8 µM	Unknown	Cushman and Cheung (1971)	5687ahtpdb / linked
CTPDB_P067228_ACT_ahtpdb_0008	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Holmquist et al. (1979)	6063ahtpdb / linked
CTPDB_P067228_ACT_ahtpdb_0009	Metabolic/Cardiovascular	ACE Inhibitor	15.0 µM	Unknown	Not reported by source	6497ahtpdb / linked
CTPDB_P067228_ACT_fermfoodb_0010	Neuroactive/Ion Channel	Analgesic	Not available in the current structured import	Unknown	LC-MS with Q Exactive Plus hybridquadrupole-Orbitrap mass spectrometer	FermFooDB_Casein_FMDB1780fermfoodb / linked
CTPDB_P067228_ACT_fermfoodb_0011	Antioxidant	-	Not available in the current structured import	Unknown	LC-MS/MS	FermFooDB_Yogurt_FMDB1311fermfoodb / linked
CTPDB_P067228_ACT_satpdb_0012	Metabolic/Cardiovascular	Antihypertensive	Not available for this observation	Unknown	Not reported by source	satpdb14106satpdb / linked

Sequence-linked cross-layer evidence

Linked primary-literature evidence

Records

Papers

Positive

Negative

Primary identities

These observations were collected directly from primary literature and linked by identical normalized sequence. They remain a separate evidence layer and do not overwrite Integrated source-database annotations.

View PEPDIA-PLP-004201 View all experimental records

Provenance

Source database records (16)

ahtpdb

4193

Raw sequence

YPFPGPIPN

ahtpdb

4609

Raw sequence

YPFPGPIPN

ahtpdb

2373

Raw sequence

YPFPGPIPN

ahtpdb

2762

Raw sequence

YPFPGPIPN

ahtpdb

1709

Raw sequence

YPFPGPIPN

ahtpdb

6063

Raw sequence

YPFPGPIPN

ahtpdb

6497

Raw sequence

YPFPGPIPN

ahtpdb

5037

Raw sequence

YPFPGPIPN

ahtpdb

5687

Raw sequence

YPFPGPIPN

ahtpdb

3619

Raw sequence

YPFPGPIPN

fermfoodb

FermFooDB_Casein_FMDB1780

Raw sequence

YPFPGPIPN

fermfoodb

FermFooDB_Casein_FMDB2162

Raw sequence

YPFPGPIPN

fermfoodb

FermFooDB_Cheese_FMDB1089

Raw sequence

YPFPGPIPN

fermfoodb

FermFooDB_Cheese_FMDB1090

Raw sequence

YPFPGPIPN

fermfoodb

FermFooDB_Yogurt_FMDB1311

Raw sequence

YPFPGPIPN

satpdb

satpdb14106

Raw sequence

YPFPGPIPN

Citation trail

Literature (13 records)

Antihypertensive peptides from food proteins: a review.

Martínez-Maqueda D1, Miralles B, Recio I, Hernández-Ledesma B.

Food Funct. 2012 Apr;3(4):350-61.2012PMID 22249830

QSAR study on angiotensin-converting enzyme inhibitor oligopeptides based on a novel set of sequence information descriptors.

Wang X1, Wang J, Lin Y, Ding Y, Wang Y, Cheng X, Lin Z.

J Mol Model. 2011 Jul;17(7):1599-606.2011PMID 20941517

A new QSAR model, for angiotensin I-converting enzyme inhibitory oligopeptides.

Sagardia I1, Roa-Ureta RH, Bald C.

Food Chem. 2013 Feb 15;136(3-4):1370-6.2013PMID 23194537

ISOLATION AND CHARACTERIZATION OF PEPTIDES WITH ANTIHYPERTENSIVE ACTIVITY IN FOODSTUFFS.

Puchalska P1, Alegre ML, López MC.

Crit Rev Food Sci Nutr. 2013 Sep 2.2013PMID 24915368

Antihypertensive peptides: production, bioavailability and incorporation into foods.

Hernández-Ledesma B1, del Mar Contreras M, Recio I.

Adv Colloid Interface Sci. 2011 Jun 9;165(1):23-352011PMID 21185549

Identification of angiotensin-I-converting enzyme inhibitory peptides derived from sodium caseinate hydrolysates produced by Lactobacillus helveticus NCC 2765

Robert, M.C. Et al.,

J Agric Food Chem 52 p.6923-312004PMID 15537298

Hypotensive peptides from milk proteins

http://www.jn.nutrition.org0

Is the structural diversity of tripeptides sufficient for developing functional food additives with satisfactory multiple bioactivities?

Jian-Hui Wang et al.,

Journal of Molecular Structure 1040 (2013) 164-1702013

Isolation and structural analysis of antihypertensive peptides that exist naturally in Gouda cheese

Saito, T et al.

Dairy Sci 83 p.1434-402000PMID 10908049

Lactic Fermentation and Bioactive Peptides

Anne Pihlanto

Lactic Acid Bacteria - R & D for Food, Health and Livestock Purposes Edited by Marcelino Kongo, ISBN 978-953-51-0955-6, 670 pages,2013

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:10.991164+00:00

Modification summary

No structured modification annotations are available for this record.

Source metadata

[
  {
    "source_db": "ahtpdb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "fermfoodb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "satpdb",
    "organism_name": "Unknown"
  }
]

Structure metadata

{
  "source_db": "satpdb",
  "dssp_states": "CCBTTTBCC"
}