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PEPDIA-INT-064110

Gold

Kn2-7

Quality

Source DBs

Activities

Source refs

Literature

Patents

Integrated record

Sequence and molecular profile

FIKRIARLLRKIF

Indexed sequence13 aa

1FIKRIARLLRKIF

Length

Molecular weight

1674.16 Da

Formula

C81H140N24O14

Structure type

Linear

Synthesis

Synthetic

Chirality

Mixed

Family

Gene

Residue composition

Physicochemical profile

Hydrophobic8

Membrane affinity proxy

Polar0

Solubility proxy

Charged5

Net charge proxy +5

Aromatic2

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

1674.1305 Da

Molecular formula

C81H140N24O14

Theoretical pI

Net charge at pH 7

4.7581

GRAVY

0.5538

Instability index

36.0615

Aromaticity

0.1538

Topological polar surface area

650.26 Å²

cLogP

-1.0005

Hydrogen-bond donors

Hydrogen-bond acceptors

Rotatable bonds

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

FIKRIARLLRKIF

HELM 2.0

validated simple linear

PEPTIDE1{F.I.K.R.I.A.R.L.L.R.K.I.F}$$$$V2.0

Canonical SMILES

validated

CCC(C)C(NC(=O)C(N)Cc1ccccc1)C(=O)NC(CCCCN)C(=O)NC(CCCNC(=N)N)C(=O)NC(C(=O)NC(C)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCCN)C(=O)NC(C(=O)NC(Cc1ccccc1)C(=O)O)C(C)CC)C(C)CC

Isomeric SMILES

validated

CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccccc1)[C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.

Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.

Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-064110,
  title = {Kn2-7},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-064110},
  note = {Accessed from local PepDiana development build}
}

APA-style note

Kn2-7. (2026). PepDiana record PEPDIA-INT-064110. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-064110

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (57 records)

Stable record	Activity	Subtype	Value	Target	Assay method	Source
CTPDB_P064110_ACT_apd_0000	Antimicrobial	Anti-Gram+	Not available in the current structured import	Unknown	Not reported by source	AP04543apd / linked
CTPDB_P064110_ACT_apd_0001	Antiviral	Anti-HIV	Not available in the current structured import	Unknown	Not reported by source	AP04543apd / linked
CTPDB_P064110_ACT_apd_0003	Immunomodulatory	Anti-sepsis	Not available in the current structured import	Unknown	Not reported by source	AP04543apd / linked
CTPDB_P064110_ACT_apd_0004	Wound Healing	Wound Healing	Not available in the current structured import	Unknown	Not reported by source	AP04543apd / linked
CTPDB_P064110_ACT_camp_0007	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ14095camp / linked
CTPDB_P064110_ACT_camp_0008	Antimicrobial	Anti-Gram-	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ14095camp / linked
CTPDB_P064110_ACT_camp_0005	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ9805camp / linked
CTPDB_P064110_ACT_camp_0006	Antimicrobial	Anti-Gram-	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ9805camp / linked
CTPDB_P064110_ACT_dbaasp_0046	Antimicrobial	-	4 µg/ml	Staphylococcus aureus NBRC 100910	Not reported by source	DBAASPS_12399_chain0dbaasp / linked
CTPDB_P064110_ACT_dbaasp_0009	Antimicrobial	-	3.13 µg/ml	Staphylococcus aureus AB94004	Not reported by source	DBAASPS_4572_chain0dbaasp / linked
CTPDB_P064110_ACT_dbaasp_0010	Antimicrobial	-	3.13 µg/ml	Staphylococcus aureus ATCC 25923	Not reported by source	DBAASPS_4572_chain0dbaasp / linked
CTPDB_P064110_ACT_dbaasp_0011	Antimicrobial	-	6.25 µg/ml	Bacillus subtilis AB91021	Not reported by source	DBAASPS_4572_chain0dbaasp / linked
CTPDB_P064110_ACT_dbaasp_0012	Antimicrobial	-	6.25 µg/ml	Bacillus thuringiensis AB92037	Not reported by source	DBAASPS_4572_chain0dbaasp / linked
CTPDB_P064110_ACT_dbaasp_0013	Antimicrobial	-	6.25 µg/ml	Micrococcus luteus AB93113	Not reported by source	DBAASPS_4572_chain0dbaasp / linked
CTPDB_P064110_ACT_dbaasp_0014	Antimicrobial	-	6.25 µg/ml	Escherichia coli AB94012	Not reported by source	DBAASPS_4572_chain0dbaasp / linked
CTPDB_P064110_ACT_dbaasp_0015	Antimicrobial	-	25 µg/ml	Escherichia coli ATCC 25922	Not reported by source	DBAASPS_4572_chain0dbaasp / linked
CTPDB_P064110_ACT_dbaasp_0016	Antimicrobial	-	25 µg/ml	Pseudomonas aeruginosa AB93066	Not reported by source	DBAASPS_4572_chain0dbaasp / linked
CTPDB_P064110_ACT_dbaasp_0017	Antimicrobial	-	50 µg/ml	Pseudomonas aeruginosa A092994	Not reported by source	DBAASPS_4572_chain0dbaasp / linked
CTPDB_P064110_ACT_dbaasp_0018	Antimicrobial	-	100 µg/ml	Pseudomonas aeruginosa A093052	Not reported by source	DBAASPS_4572_chain0dbaasp / linked
CTPDB_P064110_ACT_dbaasp_0019	Antimicrobial	-	50 µg/ml	Pseudomonas aeruginosa A093056	Not reported by source	DBAASPS_4572_chain0dbaasp / linked
CTPDB_P064110_ACT_dbaasp_0020	Antimicrobial	-	50 µg/ml	Pseudomonas aeruginosa A093085	Not reported by source	DBAASPS_4572_chain0dbaasp / linked
CTPDB_P064110_ACT_dbaasp_0021	Antimicrobial	-	100 µg/ml	Pseudomonas aeruginosa A093115	Not reported by source	DBAASPS_4572_chain0dbaasp / linked
CTPDB_P064110_ACT_dbaasp_0022	Antimicrobial	-	6.25 µg/ml	Staphylococcus aureus P1383	Not reported by source	DBAASPS_4572_chain0dbaasp / linked
CTPDB_P064110_ACT_dbaasp_0023	Antimicrobial	-	6.25 µg/ml	Staphylococcus epidermidis P1389	Not reported by source	DBAASPS_4572_chain0dbaasp / linked
CTPDB_P064110_ACT_dbaasp_0024	Antimicrobial	-	3.13 µg/ml	Staphylococcus aureus P1374	Not reported by source	DBAASPS_4572_chain0dbaasp / linked
CTPDB_P064110_ACT_dbaasp_0025	Antimicrobial	-	3.13 µg/ml	Staphylococcus aureus P1369	Not reported by source	DBAASPS_4572_chain0dbaasp / linked
CTPDB_P064110_ACT_dbaasp_0026	Antimicrobial	-	6.25 µg/ml	Staphylococcus aureus P1381	Not reported by source	DBAASPS_4572_chain0dbaasp / linked
CTPDB_P064110_ACT_dbaasp_0027	Antimicrobial	-	3.13 µg/ml	Staphylococcus epidermidis P1111	Not reported by source	DBAASPS_4572_chain0dbaasp / linked
CTPDB_P064110_ACT_dbaasp_0028	Antimicrobial	-	2.76 µg/ml	HIV-1 PsV	Not reported by source	DBAASPS_4572_chain0dbaasp / linked
CTPDB_P064110_ACT_dbaasp_0029	Antimicrobial	-	4 µg/ml	Staphylococcus aureus NBRC 100910	Not reported by source	DBAASPS_4572_chain0dbaasp / linked
CTPDB_P064110_ACT_dbaasp_0030	Antimicrobial	-	38.46 µg/ml	Human adenocarcinoma TZM-bl	Not reported by source	DBAASPS_4572_chain0dbaasp / linked
CTPDB_P064110_ACT_dbaasp_0031	Antimicrobial	-	5 µg/ml	Staphylococcus aureus ATCC 29213	Not reported by source	DBAASPS_4572_chain0dbaasp / linked
CTPDB_P064110_ACT_dbaasp_0032	Antimicrobial	-	10 µg/ml	Escherichia coli ATCC 25922	Not reported by source	DBAASPS_4572_chain0dbaasp / linked
CTPDB_P064110_ACT_dbaasp_0033	Antimicrobial	-	2.5-5 µg/ml	Staphylococcus aureus	Not reported by source	DBAASPS_4572_chain0dbaasp / linked
CTPDB_P064110_ACT_dbaasp_0034	Antimicrobial	-	2.5-5 µg/ml	Staphylococcus epidermidis	Not reported by source	DBAASPS_4572_chain0dbaasp / linked
CTPDB_P064110_ACT_dbaasp_0035	Antimicrobial	-	5 µg/ml	Enterococcus faecalis ATCC 29212	Not reported by source	DBAASPS_4572_chain0dbaasp / linked
CTPDB_P064110_ACT_dbaasp_0036	Antimicrobial	-	10 µg/ml	Enterococcus faecalis	Not reported by source	DBAASPS_4572_chain0dbaasp / linked
CTPDB_P064110_ACT_dbaasp_0037	Antimicrobial	-	5 µg/ml	Enterococcus faecium	Not reported by source	DBAASPS_4572_chain0dbaasp / linked
CTPDB_P064110_ACT_dbaasp_0038	Antimicrobial	-	10 µg/ml	Escherichia coli ATCC 35218	Not reported by source	DBAASPS_4572_chain0dbaasp / linked
CTPDB_P064110_ACT_dbaasp_0039	Antimicrobial	-	10-20 µg/ml	Escherichia coli	Not reported by source	DBAASPS_4572_chain0dbaasp / linked
CTPDB_P064110_ACT_dbaasp_0040	Antimicrobial	-	10 µg/ml	Pseudomonas aeruginosa ATCC 27853	Not reported by source	DBAASPS_4572_chain0dbaasp / linked
CTPDB_P064110_ACT_dbaasp_0041	Antimicrobial	-	10-20 µg/ml	Pseudomonas aeruginosa	Not reported by source	DBAASPS_4572_chain0dbaasp / linked
CTPDB_P064110_ACT_dbaasp_0042	Antimicrobial	-	5 µg/ml	Acinetobacter baumannii ATCC 19606	Not reported by source	DBAASPS_4572_chain0dbaasp / linked
CTPDB_P064110_ACT_dbaasp_0043	Antimicrobial	-	5-10 µg/ml	Acinetobacter baumannii	Not reported by source	DBAASPS_4572_chain0dbaasp / linked
CTPDB_P064110_ACT_dbaasp_0044	Antimicrobial	-	10 µg/ml	Klebsiella pneumoniae ATCC 700603	Not reported by source	DBAASPS_4572_chain0dbaasp / linked
CTPDB_P064110_ACT_dbaasp_0045	Antimicrobial	-	10 µg/ml	Klebsiella pneumoniae	Not reported by source	DBAASPS_4572_chain0dbaasp / linked
CTPDB_P064110_ACT_dramp_0047	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	DRAMP18558dramp / linked
CTPDB_P064110_ACT_dramp_0048	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	DRAMP18558dramp / linked
CTPDB_P064110_ACT_dramp_0049	Antimicrobial	Anti-Gram+	Not available in the current structured import	Unknown	Not reported by source	DRAMP18558dramp / linked
CTPDB_P064110_ACT_dramp_0050	Antimicrobial	Anti-Gram-	Not available in the current structured import	Unknown	Not reported by source	DRAMP18558dramp / linked
CTPDB_P064110_ACT_dramp_0051	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	DRAMP28419dramp / linked
CTPDB_P064110_ACT_dramp_0052	Antimicrobial	Antifungal	Not available in the current structured import	Unknown	Not reported by source	DRAMP28419dramp / linked
CTPDB_P064110_ACT_dramp_0053	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	DRAMP29927dramp / linked
CTPDB_P064110_ACT_dramp_0054	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	DRAMP29927dramp / linked
CTPDB_P064110_ACT_hemolytik_0055	Toxicity	Hemolytic	90.27 µg/mL	Erythrocytes	Not reported by source	2671hemolytik / linked
CTPDB_P064110_ACT_satpdb_0056	Toxicity	General Toxic	Not available in the current structured import	Unknown	Not reported by source	satpdb22294satpdb / linked
CTPDB_P064110_ACT_satpdb_0057	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	satpdb22294satpdb / linked

Sequence-linked cross-layer evidence

Linked primary-literature evidence

Records

Papers

Positive

Negative

Primary identities

These observations were collected directly from primary literature and linked by identical normalized sequence. They remain a separate evidence layer and do not overwrite Integrated source-database annotations.

View PEPDIA-PLP-003501 View all experimental records

Provenance

Source database records (10)

Source-specific sequence or modification context. One or more source records use a sequence notation that differs from the canonical backbone. Open each raw sequence before interpreting stereochemistry, terminal groups, or non-standard residues.

apd

AP04543

Raw sequence

FIKRIARLLRKIF

camp

CAMPSQ9805

Raw sequence

FIKRIARLLRKIF

camp

CAMPSQ14095

Raw sequence

FIKRIARLLRKIF

dbaasp

DBAASPS_4572_chain0

Raw sequence

FIKRIARLLRKIF

dbaasp

DBAASPS_12399_chain0

Raw sequence

fikriarllrkif

dramp

DRAMP18558

Raw sequence

FIKRIARLLRKIF

dramp

DRAMP28419

Raw sequence

FIKRIARLLRKIF

dramp

DRAMP29927

Raw sequence

fikriarllrkif

hemolytik

2671

Raw sequence

FIKRIARLLRKIF

satpdb

satpdb22294

Raw sequence

FIKRIARLLRKIF

Citation trail

Literature (5 records)

Antibacterial activity and mechanism of a scorpion venom peptide derivative in vitro and in vivo.

Cao L, Dai C, Li Z, Fan Z, Song Y, Wu Y, Cao Z, Li W.2012

PLoS One2012PMID 22792229

-

--PMID 34335511

Antibacterial activity and mechanism of a scorpion venom peptide derivative in vitro and in vivo.

Cao L, Dai C, Li Z, Fan Z, Song Y, Wu Y, Cao Z, Li W

PLoS One2012PMID 22536342

Antibacterial activity and mechanism of a scorpion venom peptide derivative in vitro and in vivo.

Cao L, Dai C, Li Z, Fan Z, Song Y, Wu Y, Cao Z, Li W

PLoS One2012PMID 28262682

Optimized peptide extraction method for analysis of antimicrobial peptide Kn2-7/dKn2-7 stability in human serum by LC-MS. Future Sci OA.

Chen W, Kirui D, Millenbaugh NJ.

Future Sci OA2022PMID 35909998

IP evidence

Patents (1)

US 10548948

dramp

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:12.728292+00:00

Modification summary

No structured modification annotations are available for this record.

ADMET

{
  "toxicity": [
    {
      "unit": "µg/ml",
      "value": "90.27",
      "source_db": "dbaasp",
      "assay_method": "50% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Human erythrocytes"
    },
    {
      "unit": "µg/ml",
      "value": "25",
      "source_db": "dbaasp",
      "assay_method": "6.9% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Human erythrocytes"
    },
    {
      "unit": "µg/ml",
      "value": "100",
      "source_db": "dbaasp",
      "assay_method": "41% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Human erythrocytes"
    },
    {
      "unit": "µM",
      "source_db": "dramp",
      "assay_method": "[Ref.22792229]Non-hemolysis at 6.25 μg/ml, 5% hemolysis at 12.5 μg/ml,10% hemolysis at 25 μg/ml 15% hemolysis at 50 μg/ml, 40% hemolysis at 100 μg/ml against human red blood cells",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Erythrocytes"
    }
  ]
}

Source metadata

[
  {
    "source_db": "apd",
    "organism_name": "Unknown"
  },
  {
    "source_db": "camp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dbaasp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dramp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "hemolytik",
    "organism_name": "Unknown"
  },
  {
    "source_db": "satpdb",
    "organism_name": "Unknown"
  }
]

Structure metadata

{
  "source_db": "satpdb",
  "dssp_states": "CHHHHTTTTSSCC"
}