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PEPDIA-INT-055865

Gold

Sequence 8 from Patent US 20090214498

85

Quality

4

Source DBs

29

Activities

35

Source refs

13

Literature

1

Patents

Integrated record

Sequence and molecular profile

RPKHPIKHQ
Indexed sequence9 aa
1RPKHPIKHQ

Length

9

Molecular weight

1140.36 Da

Formula

C51H85N19O11

Structure type

Linear

Synthesis

-

Chirality

-

Family

-

Gene

-

Residue composition

P
2
K
2
H
2
R
1
I
1
Q
1

Physicochemical profile

Hydrophobic1

Membrane affinity proxy

Polar1

Solubility proxy

Charged5

Net charge proxy +5

Aromatic2

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

1140.3414 Da

Molecular formula

C51H85N19O11

Theoretical pI

11.1663

Net charge at pH 7

2.9324

GRAVY

-2.3222

Instability index

17.6556

Aromaticity

0

Topological polar surface area

492.93 Ų

cLogP

-3.9464

Hydrogen-bond donors

16

Hydrogen-bond acceptors

16

Rotatable bonds

36

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

RPKHPIKHQ

HELM 2.0

validated simple linear

PEPTIDE1{R.P.K.H.P.I.K.H.Q}$$$$V2.0

Canonical SMILES

validated

CCC(C)C(NC(=O)C1CCCN1C(=O)C(Cc1c[nH]cn1)NC(=O)C(CCCCN)NC(=O)C1CCCN1C(=O)C(N)CCCNC(=N)N)C(=O)NC(CCCCN)C(=O)NC(Cc1c[nH]cn1)C(=O)NC(CCC(N)=O)C(=O)O

Isomeric SMILES

validated

CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)O

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.

Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.

Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-055865,
  title = {Sequence 8 from Patent US 20090214498},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-055865},
  note = {Accessed from local PepDiana development build}
}

APA-style note

Sequence 8 from Patent US 20090214498. (2026). PepDiana record PEPDIA-INT-055865. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-055865

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (29 records)

Stable recordActivitySubtypeValueTargetAssay methodSource
CTPDB_P055865_ACT_ahtpdb_0003Metabolic/CardiovascularACE Inhibitor13.4 µMUnknownCushman and Cheung (1971)1704ahtpdb / linked
CTPDB_P055865_ACT_ahtpdb_0004Metabolic/CardiovascularACE Inhibitor13.0 µMUnknownNot reported by source2366ahtpdb / linked
CTPDB_P055865_ACT_ahtpdb_0005Metabolic/CardiovascularACE Inhibitor13.4 µMUnknownAbubakar et al.2760ahtpdb / linked
CTPDB_P055865_ACT_ahtpdb_0006Metabolic/CardiovascularACE Inhibitor13.4 µMUnknownAbubakar et al.3617ahtpdb / linked
CTPDB_P055865_ACT_ahtpdb_0007Metabolic/CardiovascularACE InhibitorNot available for this observationUnknownNot reported by source3623ahtpdb / linked
CTPDB_P055865_ACT_ahtpdb_0000Metabolic/CardiovascularACE InhibitorNot available for this observationUnknownAbubakar et al.4192ahtpdb / linked
CTPDB_P055865_ACT_ahtpdb_0001Metabolic/CardiovascularACE InhibitorNot available for this observationUnknownNot reported by source4379ahtpdb / linked
CTPDB_P055865_ACT_ahtpdb_0002Metabolic/CardiovascularACE InhibitorNot available for this observationUnknownNot reported by source4608ahtpdb / linked
CTPDB_P055865_ACT_ahtpdb_0008Metabolic/CardiovascularACE InhibitorNot available for this observationUnknownNot reported by source5043ahtpdb / linked
CTPDB_P055865_ACT_ahtpdb_0009Metabolic/CardiovascularACE Inhibitor13.4 µMUnknownCushman and Cheung (1971)5685ahtpdb / linked
CTPDB_P055865_ACT_ahtpdb_0010Metabolic/CardiovascularACE InhibitorNot available for this observationUnknownHolmquist et al. (1979)6065ahtpdb / linked
CTPDB_P055865_ACT_ahtpdb_0011Metabolic/CardiovascularACE Inhibitor13.0 µMUnknownNot reported by source6494ahtpdb / linked
CTPDB_P055865_ACT_dramp_0012Antimicrobial-Not available in the current structured importUnknownNot reported by sourceDRAMP09166dramp / linked
CTPDB_P055865_ACT_fermfoodb_0013Metabolic/CardiovascularACE InhibitorNot available for this observationUnknownLC-ESI-MS/MS.FermFooDB_Casein_FMDB323fermfoodb / linked
CTPDB_P055865_ACT_fermfoodb_0014Metabolic/CardiovascularACE InhibitorNot available for this observationUnknownLC-ESI-MS/MS.FermFooDB_Casein_FMDB324fermfoodb / linked
CTPDB_P055865_ACT_fermfoodb_0015Metabolic/CardiovascularACE InhibitorNot available for this observationUnknownLC-ESI-MS/MS.FermFooDB_Casein_FMDB325fermfoodb / linked
CTPDB_P055865_ACT_fermfoodb_0016Metabolic/CardiovascularACE InhibitorNot available for this observationUnknownLC-ESI-MS/MS.FermFooDB_Casein_FMDB326fermfoodb / linked
CTPDB_P055865_ACT_fermfoodb_0017Metabolic/CardiovascularACE InhibitorNot available for this observationUnknownLC-ESI-MS/MS.FermFooDB_Casein_FMDB327fermfoodb / linked
CTPDB_P055865_ACT_fermfoodb_0018Metabolic/CardiovascularACE InhibitorNot available for this observationUnknownLC-ESI-MS/MS.FermFooDB_Casein_FMDB328fermfoodb / linked
CTPDB_P055865_ACT_fermfoodb_0019Metabolic/CardiovascularACE InhibitorNot available for this observationUnknownLC-ESI-MS/MS.FermFooDB_Casein_FMDB329fermfoodb / linked
CTPDB_P055865_ACT_fermfoodb_0020Metabolic/CardiovascularACE InhibitorNot available for this observationUnknownLC-ESI-MS/MS.FermFooDB_Casein_FMDB330fermfoodb / linked
CTPDB_P055865_ACT_fermfoodb_0021Metabolic/CardiovascularACE InhibitorNot available for this observationUnknownLC-ESI-MS/MS.FermFooDB_Casein_FMDB331fermfoodb / linked
CTPDB_P055865_ACT_fermfoodb_0022Metabolic/CardiovascularACE InhibitorNot available for this observationUnknownLC-ESI-MS/MS.FermFooDB_Casein_FMDB332fermfoodb / linked
CTPDB_P055865_ACT_fermfoodb_0023Metabolic/CardiovascularACE Inhibitor0.25 mg/mlUnknownRPHPLC; Edman degradation method using protein sequencer and MALDI-TOF-MSFermFooDB_Cheese_FMDB862fermfoodb / linked
CTPDB_P055865_ACT_fermfoodb_0024Metabolic/CardiovascularACE Inhibitor0.18 mg/mlUnknownRPHPLC; Edman degradation method using protein sequencer and MALDI-TOF-MSFermFooDB_Cheese_FMDB869fermfoodb / linked
CTPDB_P055865_ACT_fermfoodb_0025Metabolic/CardiovascularACE Inhibitor0.2 mg/mlUnknownRPHPLC; Edman degradation method using protein sequencer and MALDI-TOF-MSFermFooDB_Cheese_FMDB876fermfoodb / linked
CTPDB_P055865_ACT_fermfoodb_0027Metabolic/CardiovascularACE InhibitorNot available for this observationUnknownLC-MS/MSFermFooDB_milk_FMDB1239fermfoodb / linked
CTPDB_P055865_ACT_fermfoodb_0026Metabolic/CardiovascularACE InhibitorNot available for this observationUnknownLC-MS/MSFermFooDB_milk_FMDB1240fermfoodb / linked
CTPDB_P055865_ACT_satpdb_0028Metabolic/CardiovascularAntihypertensiveNot available for this observationUnknownNot reported by sourcesatpdb24333satpdb / linked

Sequence-linked cross-layer evidence

Linked primary-literature evidence

1

Records

1

Papers

1

Positive

0

Negative

1

Primary identities

These observations were collected directly from primary literature and linked by identical normalized sequence. They remain a separate evidence layer and do not overwrite Integrated source-database annotations.

View PEPDIA-PLP-003997View all experimental records

Provenance

Source database records (35)

ahtpdb

4192

Raw sequence

RPKHPIKHQ

ahtpdb

4379

Raw sequence

RPKHPIKHQ

ahtpdb

4608

Raw sequence

RPKHPIKHQ

ahtpdb

2366

Raw sequence

RPKHPIKHQ

ahtpdb

2760

Raw sequence

RPKHPIKHQ

ahtpdb

1704

Raw sequence

RPKHPIKHQ

ahtpdb

6065

Raw sequence

RPKHPIKHQ

ahtpdb

6494

Raw sequence

RPKHPIKHQ

ahtpdb

5043

Raw sequence

RPKHPIKHQ

ahtpdb

5685

Raw sequence

RPKHPIKHQ

ahtpdb

3617

Raw sequence

RPKHPIKHQ

ahtpdb

3623

Raw sequence

RPKHPIKHQ

dramp

DRAMP09166

Raw sequence

RPKHPIKHQ

fermfoodb

FermFooDB_Casein_FMDB2164

Raw sequence

RPKHPIKHQ

fermfoodb

FermFooDB_Casein_FMDB323

Raw sequence

RPKHPIKHQ

fermfoodb

FermFooDB_Casein_FMDB324

Raw sequence

RPKHPIKHQ

fermfoodb

FermFooDB_Casein_FMDB325

Raw sequence

RPKHPIKHQ

fermfoodb

FermFooDB_Casein_FMDB326

Raw sequence

RPKHPIKHQ

fermfoodb

FermFooDB_Casein_FMDB327

Raw sequence

RPKHPIKHQ

fermfoodb

FermFooDB_Casein_FMDB328

Raw sequence

RPKHPIKHQ

fermfoodb

FermFooDB_Casein_FMDB329

Raw sequence

RPKHPIKHQ

fermfoodb

FermFooDB_Casein_FMDB330

Raw sequence

RPKHPIKHQ

fermfoodb

FermFooDB_Casein_FMDB331

Raw sequence

RPKHPIKHQ

fermfoodb

FermFooDB_Casein_FMDB332

Raw sequence

RPKHPIKHQ

fermfoodb

FermFooDB_Cheese_FMDB1097

Raw sequence

RPKHPIKHQ

fermfoodb

FermFooDB_Cheese_FMDB1098

Raw sequence

RPKHPIKHQ

fermfoodb

FermFooDB_Cheese_FMDB1099

Raw sequence

RPKHPIKHQ

fermfoodb

FermFooDB_Cheese_FMDB862

Raw sequence

RPKHPIKHQ

fermfoodb

FermFooDB_Cheese_FMDB869

Raw sequence

RPKHPIKHQ

fermfoodb

FermFooDB_Cheese_FMDB876

Raw sequence

RPKHPIKHQ

fermfoodb

FermFooDB_milk_FMDB1240

Raw sequence

RPKHPIKHQ

fermfoodb

FermFooDB_milk_FMDB1239

Raw sequence

RPKHPIKHQ

fermfoodb

FermFooDB_milk_FMDB1220

Raw sequence

RPKHPIKHQ

fermfoodb

FermFooDB_milk_FMDB1199

Raw sequence

RPKHPIKHQ

satpdb

satpdb24333

Raw sequence

RPKHPIKHQ

Citation trail

Literature (13 records)

Antihypertensive peptides from food proteins: a review.

Martínez-Maqueda D1, Miralles B, Recio I, Hernández-Ledesma B.

Food Funct. 2012 Apr;3(4):350-61.2012PMID 22249830

Impact of milk processing on the generation of peptides during digestion

Kopf-Bolanz, Katrin A.; Schwander, Flurina; Gijs, Martin; Vergeres, Guy; Portmann, Reto; Egger, Lotti

International Dairy Journal (ISSN: 0958-6946), vol. 35, num. 2, p. 130-1382014

QSAR study on angiotensin-converting enzyme inhibitor oligopeptides based on a novel set of sequence information descriptors.

Wang X1, Wang J, Lin Y, Ding Y, Wang Y, Cheng X, Lin Z.

J Mol Model. 2011 Jul;17(7):1599-606.2011PMID 20941517

A new QSAR model, for angiotensin I-converting enzyme inhibitory oligopeptides.

Sagardia I1, Roa-Ureta RH, Bald C.

Food Chem. 2013 Feb 15;136(3-4):1370-6.2013PMID 23194537

ISOLATION AND CHARACTERIZATION OF PEPTIDES WITH ANTIHYPERTENSIVE ACTIVITY IN FOODSTUFFS.

Puchalska P1, Alegre ML, López MC.

Crit Rev Food Sci Nutr. 2013 Sep 2.2013PMID 24915368

Antihypertensive peptides: production, bioavailability and incorporation into foods.

Hernández-Ledesma B1, del Mar Contreras M, Recio I.

Adv Colloid Interface Sci. 2011 Jun 9;165(1):23-352011PMID 21185549

Identification of angiotensin-I-converting enzyme inhibitory peptides derived from sodium caseinate hydrolysates produced by Lactobacillus helveticus NCC 2765

Robert, M.C. Et al.,

J Agric Food Chem 52 p.6923-312004PMID 15537298

Hypotensive peptides from milk proteins

ND

http://www.jn.nutrition.org0

Is the structural diversity of tripeptides sufficient for developing functional food additives with satisfactory multiple bioactivities?

Jian-Hui Wang et al.,

Journal of Molecular Structure 1040 (2013) 164-1702013

Isolation and structural analysis of antihypertensive peptides that exist naturally in Gouda cheese

Saito, T et al.

Dairy Sci 83 p.1434-402000PMID 10908049

Lactic Fermentation and Bioactive Peptides

Anne Pihlanto

Lactic Acid Bacteria - R & D for Food, Health and Livestock Purposes Edited by Marcelino Kongo, ISBN 978-953-51-0955-6, 670 pages,2013

IP evidence

Patents (1)

US 20090214498

dramp

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:10.991164+00:00

Modification summary

No structured modification annotations are available for this record.

Source metadata
[
  {
    "source_db": "ahtpdb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dramp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "fermfoodb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "satpdb",
    "organism_name": "Unknown"
  }
]
Structure metadata
{
  "source_db": "satpdb",
  "dssp_states": "CCCSSSTTC"
}