Record tools

Copy identifiers or export this single peptide record for a local research note.

PEPDIA-INT-034319

Gold

Dipeptide 13

Quality

Source DBs

Activities

Source refs

Literature

Patents

Integrated record

Sequence and molecular profile

Indexed sequence2 aa

1GF

Length

Molecular weight

222.24 Da

Formula

C11H14N2O3

Structure type

Linear

Synthesis

Chirality

Family

Gene

Residue composition

Physicochemical profile

Hydrophobic1

Membrane affinity proxy

Polar0

Solubility proxy

Charged0

Net charge proxy +0

Aromatic1

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

222.2404 Da

Molecular formula

C11H14N2O3

Theoretical pI

5.525

Net charge at pH 7

-0.2399

GRAVY

1.2

Instability index

Aromaticity

0.5

Topological polar surface area

92.42 Å²

cLogP

-0.2428

Hydrogen-bond donors

Hydrogen-bond acceptors

Rotatable bonds

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

HELM 2.0

validated simple linear

PEPTIDE1{G.F}$$$$V2.0

Canonical SMILES

validated

NCC(=O)NC(Cc1ccccc1)C(=O)O

Isomeric SMILES

validated

NCC(=O)N[C@@H](Cc1ccccc1)C(=O)O

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.

Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.

Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-034319,
  title = {Dipeptide 13},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-034319},
  note = {Accessed from local PepDiana development build}
}

APA-style note

Dipeptide 13. (2026). PepDiana record PEPDIA-INT-034319. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-034319

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (39 records)

Stable record	Activity	Subtype	Value	Target	Assay method	Source
CTPDB_P034319_ACT_ahtpdb_0004	Metabolic/Cardiovascular	ACE Inhibitor	708.0 µM	Unknown	Cushman and Cheung (1971)	1112ahtpdb / linked
CTPDB_P034319_ACT_ahtpdb_0005	Metabolic/Cardiovascular	ACE Inhibitor	20.0 mM	Unknown	Not reported by source	1383ahtpdb / linked
CTPDB_P034319_ACT_ahtpdb_0006	Metabolic/Cardiovascular	ACE Inhibitor	20.0 mM	Unknown	Not reported by source	1402ahtpdb / linked
CTPDB_P034319_ACT_ahtpdb_0007	Metabolic/Cardiovascular	ACE Inhibitor	20.0 mM	Unknown	Not reported by source	1421ahtpdb / linked
CTPDB_P034319_ACT_ahtpdb_0008	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Not reported by source	1681ahtpdb / linked
CTPDB_P034319_ACT_ahtpdb_0009	Metabolic/Cardiovascular	ACE Inhibitor	277.9 µM	Unknown	Cushman and Cheung (1971)	1813ahtpdb / linked
CTPDB_P034319_ACT_ahtpdb_0010	Metabolic/Cardiovascular	ACE Inhibitor	277.9 µM	Unknown	Cushman and Cheung (1971)	2657ahtpdb / linked
CTPDB_P034319_ACT_ahtpdb_0011	Metabolic/Cardiovascular	ACE Inhibitor	275.42 µM	Unknown	Not reported by source	2791ahtpdb / linked
CTPDB_P034319_ACT_ahtpdb_0012	Metabolic/Cardiovascular	ACE Inhibitor	0.57 mg/ml	Unknown	Cushman and Cheung (1971)	2936ahtpdb / linked
CTPDB_P034319_ACT_ahtpdb_0013	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Not reported by source	3023ahtpdb / linked
CTPDB_P034319_ACT_ahtpdb_0014	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Not reported by source	3176ahtpdb / linked
CTPDB_P034319_ACT_ahtpdb_0015	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Not reported by source	3483ahtpdb / linked
CTPDB_P034319_ACT_ahtpdb_0016	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Not reported by source	3796ahtpdb / linked
CTPDB_P034319_ACT_ahtpdb_0017	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Not reported by source	3841ahtpdb / linked
CTPDB_P034319_ACT_ahtpdb_0018	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Not reported by source	3918ahtpdb / linked
CTPDB_P034319_ACT_ahtpdb_0000	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Cushman and Cheung (1971)	4232ahtpdb / linked
CTPDB_P034319_ACT_ahtpdb_0001	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Not reported by source	4430ahtpdb / linked
CTPDB_P034319_ACT_ahtpdb_0002	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Not reported by source	4502ahtpdb / linked
CTPDB_P034319_ACT_ahtpdb_0003	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Not reported by source	4697ahtpdb / linked
CTPDB_P034319_ACT_ahtpdb_0019	Metabolic/Cardiovascular	ACE Inhibitor	277.9 µM	Unknown	Not reported by source	5149ahtpdb / linked
CTPDB_P034319_ACT_ahtpdb_0020	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Not reported by source	5427ahtpdb / linked
CTPDB_P034319_ACT_ahtpdb_0021	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Not reported by source	5455ahtpdb / linked
CTPDB_P034319_ACT_ahtpdb_0022	Metabolic/Cardiovascular	ACE Inhibitor	277.9 µM	Unknown	Cushman and Cheung (1971)	5744ahtpdb / linked
CTPDB_P034319_ACT_ahtpdb_0023	Metabolic/Cardiovascular	ACE Inhibitor	630.0 µM	Unknown	Not reported by source	6577ahtpdb / linked
CTPDB_P034319_ACT_dramp_0024	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	DRAMP35025dramp / linked
CTPDB_P034319_ACT_dramp_0025	Anticancer	-	Not available in the current structured import	Unknown	Not reported by source	DRAMP35025dramp / linked
CTPDB_P034319_ACT_parapep_0026	Antiparasitic	Antiparasitic	164.05 µM	Unknown	Microscopy	1161parapep / linked
CTPDB_P034319_ACT_plantpepdb_0027	Enzyme Inhibitor	General Enzyme Inhibitor	Not available in the current structured import	Unknown	Not reported by source	PPepDB_2966plantpepdb / linked
CTPDB_P034319_ACT_plantpepdb_0028	Neuroactive/Ion Channel	Neuropeptide	Not available in the current structured import	Unknown	Not reported by source	PPepDB_2966plantpepdb / linked
CTPDB_P034319_ACT_plantpepdb_0029	Metabolic/Cardiovascular	Antihypertensive	Not available for this observation	Unknown	Not reported by source	PPepDB_2966plantpepdb / linked
CTPDB_P034319_ACT_plantpepdb_0030	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Not reported by source	PPepDB_2966plantpepdb / linked
CTPDB_P034319_ACT_plantpepdb_0031	Unknown	Taste	Not available in the current structured import	Unknown	Not reported by source	PPepDB_2966plantpepdb / linked
CTPDB_P034319_ACT_satpdb_0032	Anticancer	-	Not available in the current structured import	Unknown	Not reported by source	satpdb12994satpdb / linked
CTPDB_P034319_ACT_satpdb_0033	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	satpdb12994satpdb / linked
CTPDB_P034319_ACT_satpdb_0034	Antiviral	-	Not available in the current structured import	Unknown	Not reported by source	satpdb12994satpdb / linked
CTPDB_P034319_ACT_satpdb_0035	Antiparasitic	-	Not available in the current structured import	Unknown	Not reported by source	satpdb12994satpdb / linked
CTPDB_P034319_ACT_satpdb_0036	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	satpdb12994satpdb / linked
CTPDB_P034319_ACT_satpdb_0037	Antimicrobial	Antifungal	Not available in the current structured import	Unknown	Not reported by source	satpdb12994satpdb / linked
CTPDB_P034319_ACT_satpdb_0038	Metabolic/Cardiovascular	Antihypertensive	Not available for this observation	Unknown	Not reported by source	satpdb28732satpdb / linked

Sequence-linked cross-layer evidence

Linked primary-literature evidence

Records

Papers

Positive

Negative

Primary identities

These observations were collected directly from primary literature and linked by identical normalized sequence. They remain a separate evidence layer and do not overwrite Integrated source-database annotations.

View PEPDIA-PLP-003555 View all experimental records

Provenance

Source database records (29)

ahtpdb

4232

Raw sequence

ahtpdb

4430

Raw sequence

ahtpdb

4502

Raw sequence

ahtpdb

4697

Raw sequence

ahtpdb

2657

Raw sequence

ahtpdb

2791

Raw sequence

ahtpdb

2936

Raw sequence

ahtpdb

1112

Raw sequence

ahtpdb

1383

Raw sequence

ahtpdb

1402

Raw sequence

ahtpdb

1421

Raw sequence

ahtpdb

1681

Raw sequence

ahtpdb

1813

Raw sequence

ahtpdb

6577

Raw sequence

ahtpdb

5149

Raw sequence

ahtpdb

5427

Raw sequence

ahtpdb

5455

Raw sequence

ahtpdb

5744

Raw sequence

ahtpdb

3023

Raw sequence

ahtpdb

3176

Raw sequence

ahtpdb

3483

Raw sequence

ahtpdb

3796

Raw sequence

ahtpdb

3841

Raw sequence

ahtpdb

3918

Raw sequence

dramp

DRAMP35025

Raw sequence

parapep

1161

Raw sequence

plantpepdb

PPepDB_2966

Raw sequence

satpdb

satpdb12994

Raw sequence

satpdb

satpdb28732

Raw sequence

Citation trail

Literature (20 records)

Antihypertensive peptides from food proteins: a review.

Martínez-Maqueda D1, Miralles B, Recio I, Hernández-Ledesma B.

Food Funct. 2012 Apr;3(4):350-61.2012PMID 22249830

Modelling relationship between angiotensin-(I)-converting enzyme inhibition and the bitter taste of peptides

Are Hugo Pripp, Ylva Ardö

Food Chemistry - FOOD CHEM 01/2007; 102(3):880-888.2007

QSAR study on angiotensin-converting enzyme inhibitor oligopeptides based on a novel set of sequence information descriptors.

Wang X1, Wang J, Lin Y, Ding Y, Wang Y, Cheng X, Lin Z.

J Mol Model. 2011 Jul;17(7):1599-606.2011PMID 20941517

What are the ideal properties for functional food peptides with antihypertensive effect? A computational peptidology approach.

Zhou P et al.

Food Chem. 2013 Dec 1;141(3):2967-73.2013PMID 23871047

ISOLATION AND CHARACTERIZATION OF PEPTIDES WITH ANTIHYPERTENSIVE ACTIVITY IN FOODSTUFFS.

Puchalska P1, Alegre ML, López MC.

Crit Rev Food Sci Nutr. 2013 Sep 2.2013PMID 24915368

Predictive modelling of angiotensin converting enzyme inhibitory dipeptides

Norris, Roseanne; Casey, Fergal; FitzGerald, Richard; Shields, Denis C.; Mooney, Catherine;

Food Chemistry 133(4), 15 August 2012, Pages 1349–13542012

ANGIOTENSIN CONVERTING ENZYME INHIBI TO RY PEPTIDES FROM AQUATIC AND THEIR PROCESSING BY-PRODUCTS: A REVIEW

Sunantha Ketnawa and Saroat Rawdkuen

IJSID, 2012, 2 (6), 185-1992012

Review on the angiotensin-I-converting enzyme (ACE) inhibitor peptides from marine proteins.

He HL1, Liu D, Ma CB.

Appl Biochem Biotechnol. 2013 Feb;169(3):738-49.2013PMID 23271625

Structural requirements of Angiotensin I-converting enzyme inhibitory peptides: quantitative structure-activity relationship study of di- and tripeptides.

Wu J1, Aluko RE, Nakai S.

J Agric Food Chem. 2006 Feb 8;54(3):732-8.2006PMID 16448176

BIOPEP-PBIL Tool for the Analysis of the Structure of Biologically Active Motifs Derived from Food Proteins

Anna Iwaniak* and Jerzy Dziuba

Analysis of Biologically Active Motifs, Food Technol. Biotechnol. 49 (1) 118–127 (2011)2011

Vegetable foods: A cheap source of proteins and peptides with antihypertensive, antioxidant, and other less occurrence bioactivities.

M C García, P Puchalska, C Esteve, M L Marina

Talanta 03/2013; 106C:328-349.2013PMID 23598136

Binding of peptide substrates and inhibitors of angiotensin-converting enzyme. Importance of the COOH-terminal dipeptide sequence.

Cheung HS et al.,

J Biol Chem. 1980 Jan 25;255(2):401-7.1980PMID 6243277

Integration of QSAR modelling and QM/MM analysis to investigate functional food peptides with antihypertensive activity

Jin Tan et al.

Molecular Simulation Volume 39, Issue 12, 20132013

Quantitative structure-activity relationship study of bitter di- and tri-peptides including relationship with angiotensin I-converting enzyme inhibitory activity.

Wu J1, Aluko RE.

J Pept Sci. 2007 Jan;13(1):63-9.2007PMID 17117396

Isolation and characterization of angiotensin I-converting enzyme inhibitor dipeptides derived from Allium sativum L (garlic)

Suetsuna, K.;

J Nutr Biochem 9 p.415-4191998

Peptides with angiotensin I converting enzyme (ACE) inhibitory activity generated from porcine skeletal muscle proteins by the action of meat-borne Lactobacillus.

Castellano P1, Aristoy MC, Sentandreu MÁ, Vignolo G, Toldrá F.

J Proteomics. 2013 Aug 26;89:183-90.2013PMID 23806758

MOTIFS WITH POTENTIAL PHYSIOLOGICAL ACTIVITY IN FOOD PROTEINS - BIOPEP DATABASE

Iwaniak, Anna; Dziuba, Bartlomiej

Acta Scientiarum Polonorum. Technologia Alimentaria;2009, Vol. 8 Issue 3, p592009

Three-dimensional holograph vector of atomic interaction field (3D-HoVAIF): a novel rotation-translation invariant 3D structure descriptor and its applications to peptides.

Tian F1, Zhou P, Lv F, Song R, Li Z.

J Pept Sci. 2007 Aug;13(8):549-66.2007PMID 17654623

Identification of Bioactive Peptides from Cereal Storage Proteins and Their Potential Role in Prevention of Chronic Diseases

Ariel Cavazos and Elvira Gonzalez de Mejia

Comprehensive Reviews in Food Science and Food Safety Volume 12, Issue 4, pages 364–380, July 20132013

Linear and cyclic dipeptides with antimalarial activity.

Pérez-Picaso L, Olivo HF, Argotte-Ramos R, Rodríguez-Gutiérrez M, Rios MY.

Bioorg Med Chem Lett2012PMID 23084276

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:10.991164+00:00

Modification summary

No structured modification annotations are available for this record.

Source metadata

[
  {
    "source_db": "ahtpdb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dramp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "parapep",
    "organism_name": "Unknown"
  },
  {
    "source_db": "plantpepdb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "satpdb",
    "organism_name": "Unknown"
  }
]

Structure metadata

{
  "source_db": "satpdb",
  "dssp_states": "CC"
}