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PEPDIA-INT-033534

Gold

Casecidin 17, Beta-casein

Quality

Source DBs

Activities

Source refs

Literature

Patents

Integrated record

Sequence and molecular profile

YQEPVLGPVRGPFPIIV

Indexed sequence17 aa

1YQEPVLGPVRGPFPIIV

Length

Molecular weight

1881.25 Da

Formula

C91H141N21O22

Structure type

Linear

Synthesis

Ribosomal

Chirality

Family

Gene

Residue composition

Physicochemical profile

Hydrophobic8

Membrane affinity proxy

Polar1

Solubility proxy

Charged2

Net charge proxy +0

Aromatic2

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

1881.2204 Da

Molecular formula

C91H141N21O22

Theoretical pI

6.0014

Net charge at pH 7

-0.2381

GRAVY

0.4824

Instability index

67.4

Aromaticity

0.1176

Topological polar surface area

656.28 Å²

cLogP

-1.8664

Hydrogen-bond donors

Hydrogen-bond acceptors

Rotatable bonds

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

YQEPVLGPVRGPFPIIV

HELM 2.0

validated simple linear

PEPTIDE1{Y.Q.E.P.V.L.G.P.V.R.G.P.F.P.I.I.V}$$$$V2.0

Canonical SMILES

validated

CCC(C)C(NC(=O)C(NC(=O)C1CCCN1C(=O)C(Cc1ccccc1)NC(=O)C1CCCN1C(=O)CNC(=O)C(CCCNC(=N)N)NC(=O)C(NC(=O)C1CCCN1C(=O)CNC(=O)C(CC(C)C)NC(=O)C(NC(=O)C1CCCN1C(=O)C(CCC(=O)O)NC(=O)C(CCC(N)=O)NC(=O)C(N)Cc1ccc(O)cc1)C(C)C)C(C)C)C(C)CC)C(=O)NC(C(=O)O)C(C)C

Isomeric SMILES

validated

CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(C)C)[C@@H](C)CC)C(=O)N[C@H](C(=O)O)C(C)C

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.

Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.

Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-033534,
  title = {Casecidin 17, Beta-casein},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-033534},
  note = {Accessed from local PepDiana development build}
}

APA-style note

Casecidin 17, Beta-casein. (2026). PepDiana record PEPDIA-INT-033534. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-033534

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (44 records)

Stable record	Activity	Subtype	Value	Target	Assay method	Source
CTPDB_P033534_ACT_ahtpdb_0000	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Not reported by source	3627ahtpdb / linked
CTPDB_P033534_ACT_ahtpdb_0001	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Not reported by source	3637ahtpdb / linked
CTPDB_P033534_ACT_ahtpdb_0002	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Not reported by source	5551ahtpdb / linked
CTPDB_P033534_ACT_ahtpdb_0003	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Holmquist et al. (1979)	6067ahtpdb / linked
CTPDB_P033534_ACT_apd_0004	Antimicrobial	Anti-Gram-	Not available in the current structured import	Unknown	Not reported by source	AP01398apd / linked
CTPDB_P033534_ACT_camp_0005	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ3213camp / linked
CTPDB_P033534_ACT_dbaasp_0006	Antimicrobial	-	0.5 µg/ml	Escherichia coli DH5alpha	Not reported by source	DBAASPS_2309_chain0dbaasp / linked
CTPDB_P033534_ACT_dbaasp_0007	Antimicrobial	-	0.4 µg/ml	Escherichia coli DPC 6053	Not reported by source	DBAASPS_2309_chain0dbaasp / linked
CTPDB_P033534_ACT_dbaasp_0008	Antimicrobial	-	>1.0 µg/ml	Cronobacter sakazakii DPC 5120	Not reported by source	DBAASPS_2309_chain0dbaasp / linked
CTPDB_P033534_ACT_dramp_0009	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	DRAMP32371dramp / linked
CTPDB_P033534_ACT_dramp_0010	Anticancer	-	Not available in the current structured import	Unknown	Not reported by source	DRAMP32371dramp / linked
CTPDB_P033534_ACT_fermfoodb_0011	Metabolic/Cardiovascular	ACE Inhibitor	0.14 µM	Unknown	MALDI-TOF/TOF MS	FermFooDB_Casein_FMDB1669fermfoodb / linked
CTPDB_P033534_ACT_fermfoodb_0012	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Lb. casei Shirota	FermFooDB_Casein_FMDB1670fermfoodb / linked
CTPDB_P033534_ACT_fermfoodb_0013	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	FermFooDB_Casein_FMDB1756fermfoodb / linked
CTPDB_P033534_ACT_fermfoodb_0014	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	FermFooDB_Casein_FMDB1757fermfoodb / linked
CTPDB_P033534_ACT_fermfoodb_0015	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	FermFooDB_Casein_FMDB1758fermfoodb / linked
CTPDB_P033534_ACT_fermfoodb_0016	Antimicrobial	-	Not available in the current structured import	Unknown	LC-MS with Q Exactive Plus hybridquadrupole-Orbitrap mass spectrometer	FermFooDB_Casein_FMDB1759fermfoodb / linked
CTPDB_P033534_ACT_fermfoodb_0017	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	LC-ESI-MS/MS.	FermFooDB_Casein_FMDB280fermfoodb / linked
CTPDB_P033534_ACT_fermfoodb_0018	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	LC-ESI-MS/MS.	FermFooDB_Casein_FMDB281fermfoodb / linked
CTPDB_P033534_ACT_fermfoodb_0019	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	LC-ESI-MS/MS.	FermFooDB_Casein_FMDB282fermfoodb / linked
CTPDB_P033534_ACT_fermfoodb_0020	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	LC-ESI-MS/MS.	FermFooDB_Casein_FMDB283fermfoodb / linked
CTPDB_P033534_ACT_fermfoodb_0021	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	LC-ESI-MS/MS.	FermFooDB_Casein_FMDB284fermfoodb / linked
CTPDB_P033534_ACT_fermfoodb_0022	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	LC-ESI-MS/MS.	FermFooDB_Casein_FMDB285fermfoodb / linked
CTPDB_P033534_ACT_fermfoodb_0023	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	LC-ESI-MS/MS.	FermFooDB_Casein_FMDB286fermfoodb / linked
CTPDB_P033534_ACT_fermfoodb_0024	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	LC-ESI-MS/MS.	FermFooDB_Casein_FMDB287fermfoodb / linked
CTPDB_P033534_ACT_fermfoodb_0025	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	LC-ESI-MS/MS.	FermFooDB_Casein_FMDB288fermfoodb / linked
CTPDB_P033534_ACT_fermfoodb_0026	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	LC-ESI-MS/MS.	FermFooDB_Casein_FMDB289fermfoodb / linked
CTPDB_P033534_ACT_fermfoodb_0027	Metabolic/Cardiovascular	Antithrombotic	0.14 µM	Unknown	MALDI-TOF/TOF MS	FermFooDB_Casein_FMDB816fermfoodb / linked
CTPDB_P033534_ACT_fermfoodb_0028	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Lactobacillus caseiShirota and Streptococcus thermophilus	FermFooDB_Casein_FMDB817fermfoodb / linked
CTPDB_P033534_ACT_fermfoodb_0029	Metabolic/Cardiovascular	ACE Inhibitor	5.3 µM	Unknown	LC-ESI-MS	FermFooDB_Cheese_FMDB339fermfoodb / linked
CTPDB_P033534_ACT_fermfoodb_0030	Metabolic/Cardiovascular	ACE Inhibitor	10.4 µM	Unknown	LC-ESI-MS	FermFooDB_Cheese_FMDB342fermfoodb / linked
CTPDB_P033534_ACT_fermfoodb_0031	Metabolic/Cardiovascular	ACE Inhibitor	10.4 µM	Unknown	LC-ESI-MS	FermFooDB_Cheese_FMDB348fermfoodb / linked
CTPDB_P033534_ACT_fermfoodb_0032	Metabolic/Cardiovascular	ACE Inhibitor	0.14 mg/ml	Unknown	RPHPLC; Edman degradation method using protein sequencer and MALDI-TOF-MS	FermFooDB_Cheese_FMDB868fermfoodb / linked
CTPDB_P033534_ACT_fermfoodb_0033	Metabolic/Cardiovascular	ACE Inhibitor	0.17 mg/ml	Unknown	RPHPLC; Edman degradation method using protein sequencer and MALDI-TOF-MS	FermFooDB_Cheese_FMDB875fermfoodb / linked
CTPDB_P033534_ACT_fermfoodb_0034	Metabolic/Cardiovascular	ACE Inhibitor	0.14 mg/ml	Unknown	RPHPLC; Edman degradation method using protein sequencer and MALDI-TOF-MS	FermFooDB_Cheese_FMDB882fermfoodb / linked
CTPDB_P033534_ACT_fermfoodb_0039	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	FermFooDB_milk_FMDB1756fermfoodb / linked
CTPDB_P033534_ACT_fermfoodb_0038	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	FermFooDB_milk_FMDB1757fermfoodb / linked
CTPDB_P033534_ACT_fermfoodb_0037	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	FermFooDB_milk_FMDB1758fermfoodb / linked
CTPDB_P033534_ACT_fermfoodb_0036	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	LC-ESI-TOF-MS/MS	FermFooDB_milk_FMDB77fermfoodb / linked
CTPDB_P033534_ACT_fermfoodb_0035	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	L.acidophilus NCDC-15,Lactococcus lactis NCDC-167 and S. thermophilus	FermFooDB_milk_FMDB774fermfoodb / linked
CTPDB_P033534_ACT_plantpepdb_0040	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Not reported by source	PPepDB_3712plantpepdb / linked
CTPDB_P033534_ACT_satpdb_0041	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	satpdb24545satpdb / linked
CTPDB_P033534_ACT_satpdb_0042	Metabolic/Cardiovascular	Antihypertensive	Not available for this observation	Unknown	Not reported by source	satpdb24545satpdb / linked
CTPDB_P033534_ACT_satpdb_0043	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	satpdb24545satpdb / linked

Sequence-linked cross-layer evidence

Linked primary-literature evidence

Records

Papers

Positive

Negative

Primary identities

These observations were collected directly from primary literature and linked by identical normalized sequence. They remain a separate evidence layer and do not overwrite Integrated source-database annotations.

View PEPDIA-PLP-004212 View all experimental records

Provenance

Source database records (49)

ahtpdb

6067

Raw sequence

YQEPVLGPVRGPFPIIV

ahtpdb

5551

Raw sequence

YQEPVLGPVRGPFPIIV

ahtpdb

3627

Raw sequence

YQEPVLGPVRGPFPIIV

ahtpdb

3637

Raw sequence

YQEPVLGPVRGPFPIIV

apd

AP01398

Raw sequence

YQEPVLGPVRGPFPIIV

camp

CAMPSQ3213

Raw sequence

YQEPVLGPVRGPFPIIV

dbaasp

DBAASPS_2309_chain0

Raw sequence

YQEPVLGPVRGPFPIIV

dramp

DRAMP32371

Raw sequence

YQEPVLGPVRGPFPIIV

fermfoodb

FermFooDB_Casein_FMDB1669

Raw sequence

YQEPVLGPVRGPFPIIV

fermfoodb

FermFooDB_Casein_FMDB1670

Raw sequence

YQEPVLGPVRGPFPIIV

fermfoodb

FermFooDB_Casein_FMDB1724

Raw sequence

YQEPVLGPVRGPFPIIV

fermfoodb

FermFooDB_Casein_FMDB1756

Raw sequence

YQEPVLGPVRGPFPIIV

fermfoodb

FermFooDB_Casein_FMDB1757

Raw sequence

YQEPVLGPVRGPFPIIV

fermfoodb

FermFooDB_Casein_FMDB1758

Raw sequence

YQEPVLGPVRGPFPIIV

fermfoodb

FermFooDB_Casein_FMDB1759

Raw sequence

YQEPVLGPVRGPFPIIV

fermfoodb

FermFooDB_Casein_FMDB2100

Raw sequence

YQEPVLGPVRGPFPIIV

fermfoodb

FermFooDB_Casein_FMDB2166

Raw sequence

YQEPVLGPVRGPFPIIV

fermfoodb

FermFooDB_Casein_FMDB280

Raw sequence

YQEPVLGPVRGPFPIIV

fermfoodb

FermFooDB_Casein_FMDB281

Raw sequence

YQEPVLGPVRGPFPIIV

fermfoodb

FermFooDB_Casein_FMDB282

Raw sequence

YQEPVLGPVRGPFPIIV

fermfoodb

FermFooDB_Casein_FMDB283

Raw sequence

YQEPVLGPVRGPFPIIV

fermfoodb

FermFooDB_Casein_FMDB284

Raw sequence

YQEPVLGPVRGPFPIIV

fermfoodb

FermFooDB_Casein_FMDB285

Raw sequence

YQEPVLGPVRGPFPIIV

fermfoodb

FermFooDB_Casein_FMDB286

Raw sequence

YQEPVLGPVRGPFPIIV

fermfoodb

FermFooDB_Casein_FMDB287

Raw sequence

YQEPVLGPVRGPFPIIV

fermfoodb

FermFooDB_Casein_FMDB288

Raw sequence

YQEPVLGPVRGPFPIIV

fermfoodb

FermFooDB_Casein_FMDB289

Raw sequence

YQEPVLGPVRGPFPIIV

fermfoodb

FermFooDB_Casein_FMDB816

Raw sequence

YQEPVLGPVRGPFPIIV

fermfoodb

FermFooDB_Casein_FMDB817

Raw sequence

YQEPVLGPVRGPFPIIV

fermfoodb

FermFooDB_Cheese_FMDB1121

Raw sequence

YQEPVLGPVRGPFPIIV

fermfoodb

FermFooDB_Cheese_FMDB1122

Raw sequence

YQEPVLGPVRGPFPIIV

fermfoodb

FermFooDB_Cheese_FMDB1123

Raw sequence

YQEPVLGPVRGPFPIIV

fermfoodb

FermFooDB_Cheese_FMDB339

Raw sequence

YQEPVLGPVRGPFPIIV

fermfoodb

FermFooDB_Cheese_FMDB342

Raw sequence

YQEPVLGPVRGPFPIIV

fermfoodb

FermFooDB_Cheese_FMDB348

Raw sequence

YQEPVLGPVRGPFPIIV

fermfoodb

FermFooDB_Cheese_FMDB868

Raw sequence

YQEPVLGPVRGPFPIIV

fermfoodb

FermFooDB_Cheese_FMDB875

Raw sequence

YQEPVLGPVRGPFPIIV

fermfoodb

FermFooDB_Cheese_FMDB882

Raw sequence

YQEPVLGPVRGPFPIIV

fermfoodb

FermFooDB_milk_FMDB774

Raw sequence

YQEPVLGPVRGPFPIIV

fermfoodb

FermFooDB_milk_FMDB77

Raw sequence

YQEPVLGPVRGPFPIIV

fermfoodb

FermFooDB_milk_FMDB1758

Raw sequence

YQEPVLGPVRGPFPIIV

fermfoodb

FermFooDB_milk_FMDB1757

Raw sequence

YQEPVLGPVRGPFPIIV

fermfoodb

FermFooDB_milk_FMDB1756

Raw sequence

YQEPVLGPVRGPFPIIV

fermfoodb

FermFooDB_milk_FMDB134

Raw sequence

YQEPVLGPVRGPFPIIV

fermfoodb

FermFooDB_milk_FMDB133

Raw sequence

YQEPVLGPVRGPFPIIV

fermfoodb

FermFooDB_milk_FMDB132

Raw sequence

YQEPVLGPVRGPFPIIV

fermfoodb

FermFooDB_milk_FMDB131

Raw sequence

YQEPVLGPVRGPFPIIV

plantpepdb

PPepDB_3712

Raw sequence

YQEPVLGPVRGPFPIIV

satpdb

satpdb24545

Raw sequence

YQEPVLGPVRGPFPIIV

Citation trail

Literature (15 records)

Identification of angiotensin-I-converting enzyme inhibitory peptides derived from sodium caseinate hydrolysates produced by Lactobacillus helveticus NCC 2765

Robert, M.C. Et al.,

J Agric Food Chem 52 p.6923-312004PMID 15537298

Analysis of the Endogenous Peptide Profile of Milk: Identification of 248 Mainly Casein-Derived Peptides

Florian Baum et al.

J. Proteome Res., 2013, 12 (12), pp 5447–54622013

Lactic Fermentation and Bioactive Peptides

Anne Pihlanto

Lactic Acid Bacteria - R & D for Food, Health and Livestock Purposes Edited by Marcelino Kongo, ISBN 978-953-51-0955-6, 670 pages,2013

Antimicrobial activity of two peptides casecidin 15 and 17, found naturally in bovine colostrum

Birkemo GA, O'Sullivan O, Ross RP, Hill C2009

J Appl Microbiol2009PMID 19054235

{"title": "Antioxidant peptides isolated from synbiotic yoghurt exhibit antiproliferative activities against HT-29 colon cancer cells"}

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:11.196781+00:00

Modification summary

No structured modification annotations are available for this record.

Source metadata

[
  {
    "source_db": "ahtpdb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "apd",
    "organism_name": "Unknown"
  },
  {
    "source_db": "camp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dbaasp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dramp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "fermfoodb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "plantpepdb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "satpdb",
    "organism_name": "Unknown"
  }
]

Structure metadata

{
  "source_db": "satpdb",
  "dssp_states": "CCCSSSSSSSSSCCSCC"
}