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PEPDIA-INT-031918

Gold

ACE inhibitory peptide

Quality

Source DBs

Activities

Source refs

Literature

Patents

Integrated record

Sequence and molecular profile

LVQGS

Indexed sequence5 aa

1LVQGS

Length

Molecular weight

502.57 Da

Formula

C21H38N6O8

Structure type

Linear

Synthesis

Chirality

Family

Gene

Residue composition

Physicochemical profile

Hydrophobic2

Membrane affinity proxy

Polar2

Solubility proxy

Charged0

Net charge proxy +0

Aromatic0

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

502.5617 Da

Molecular formula

C21H38N6O8

Theoretical pI

5.525

Net charge at pH 7

-0.2399

GRAVY

0.66

Instability index

Aromaticity

Topological polar surface area

243.04 Å²

cLogP

-3.0712

Hydrogen-bond donors

Hydrogen-bond acceptors

Rotatable bonds

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

LVQGS

HELM 2.0

validated simple linear

PEPTIDE1{L.V.Q.G.S}$$$$V2.0

Canonical SMILES

validated

CC(C)CC(N)C(=O)NC(C(=O)NC(CCC(N)=O)C(=O)NCC(=O)NC(CO)C(=O)O)C(C)C

Isomeric SMILES

validated

CC(C)C[C@H](N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)O)C(C)C

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.

Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.

Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-031918,
  title = {ACE inhibitory peptide},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-031918},
  note = {Accessed from local PepDiana development build}
}

APA-style note

ACE inhibitory peptide. (2026). PepDiana record PEPDIA-INT-031918. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-031918

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (9 records)

Stable record	Activity	Subtype	Value	Target	Assay method	Source
CTPDB_P031918_ACT_ahtpdb_0000	Metabolic/Cardiovascular	ACE Inhibitor	43.7 µM	Unknown	Cushman and Cheung (1971)	1898ahtpdb / linked
CTPDB_P031918_ACT_ahtpdb_0001	Metabolic/Cardiovascular	ACE Inhibitor	43.7 µM	Unknown	Cushman and Cheung (1971)	2700ahtpdb / linked
CTPDB_P031918_ACT_ahtpdb_0002	Metabolic/Cardiovascular	ACE Inhibitor	43.7 µM	Unknown	Not reported by source	5329ahtpdb / linked
CTPDB_P031918_ACT_ahtpdb_0003	Metabolic/Cardiovascular	ACE Inhibitor	43.7 µM	Unknown	Cushman and Cheung (1971)	6217ahtpdb / linked
CTPDB_P031918_ACT_fermfoodb_0004	Metabolic/Cardiovascular	ACE Inhibitor	43.7 µM	Unknown	MALDI-ToF MS and liquid-phase peptide sequencer	FermFooDB_Soyabean_FMDB2202fermfoodb / linked
CTPDB_P031918_ACT_fermfoodb_0005	Metabolic/Cardiovascular	ACE Inhibitor	43.7 µM	Unknown	MALDI TOF MS and peptide sequencer	FermFooDB_Soyabean_FMDB992fermfoodb / linked
CTPDB_P031918_ACT_plantpepdb_0006	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Not reported by source	PPepDB_3733plantpepdb / linked
CTPDB_P031918_ACT_plantpepdb_0007	Metabolic/Cardiovascular	Antihypertensive	Not available for this observation	Unknown	Not reported by source	PPepDB_3733plantpepdb / linked
CTPDB_P031918_ACT_satpdb_0008	Metabolic/Cardiovascular	Antihypertensive	Not available for this observation	Unknown	Not reported by source	satpdb20698satpdb / linked

Sequence-linked cross-layer evidence

Linked primary-literature evidence

Records

Papers

Positive

Negative

Primary identities

These observations were collected directly from primary literature and linked by identical normalized sequence. They remain a separate evidence layer and do not overwrite Integrated source-database annotations.

View PEPDIA-PLP-003870 View all experimental records

Provenance

Source database records (8)

ahtpdb

2700

Raw sequence

LVQGS

ahtpdb

1898

Raw sequence

LVQGS

ahtpdb

6217

Raw sequence

LVQGS

ahtpdb

5329

Raw sequence

LVQGS

fermfoodb

FermFooDB_Soyabean_FMDB2202

Raw sequence

LVQGS

fermfoodb

FermFooDB_Soyabean_FMDB992

Raw sequence

LVQGS

plantpepdb

PPepDB_3733

Raw sequence

LVQGS

satpdb

satpdb20698

Raw sequence

LVQGS

Citation trail

Literature (5 records)

ISOLATION AND CHARACTERIZATION OF PEPTIDES WITH ANTIHYPERTENSIVE ACTIVITY IN FOODSTUFFS.

Puchalska P1, Alegre ML, López MC.

Crit Rev Food Sci Nutr. 2013 Sep 2.2013PMID 24915368

Vegetable foods: A cheap source of proteins and peptides with antihypertensive, antioxidant, and other less occurrence bioactivities.

M C García, P Puchalska, C Esteve, M L Marina

Talanta 03/2013; 106C:328-349.2013PMID 23598136

Purification and identification of an angiotensin I-converting enzyme inhibitory peptide from fermented soybean extract

Kuba, M et al.,

Process Biochem 44 p.490-4932009

Integration of QSAR modelling and QM/MM analysis to investigate functional food peptides with antihypertensive activity

Jin Tan et al.

Molecular Simulation Volume 39, Issue 12, 20132013

-

--PMID 28317757

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:11.113046+00:00

Modification summary

No structured modification annotations are available for this record.

Source metadata

[
  {
    "source_db": "ahtpdb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "fermfoodb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "plantpepdb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "satpdb",
    "organism_name": "Unknown"
  }
]

Structure metadata

{
  "source_db": "satpdb",
  "dssp_states": "CCSCC"
}