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PEPDIA-INT-028888

Gold

Lycotoxin-1, M-lycotoxin-Hc1a

Quality

Source DBs

Activities

Source refs

Literature

Patents

Integrated record

Sequence and molecular profile

IWLTALKFLGKHAAKHLAKQQLSKL

Indexed sequence25 aa

1IWLTALKFLGKHAAKHLAKQQLSKL

Length

Molecular weight

2844.50 Da

Formula

C135H223N37O30

Structure type

Linear

Synthesis

Ribosomal

Chirality

Family

Gene

Residue composition

Physicochemical profile

Hydrophobic13

Membrane affinity proxy

Polar4

Solubility proxy

Charged7

Net charge proxy +7

Aromatic4

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

2844.4448 Da

Molecular formula

C135H223N37O30

Theoretical pI

10.6025

Net charge at pH 7

4.9295

GRAVY

0.064

Instability index

21.508

Aromaticity

0.08

Topological polar surface area

1091.61 Å²

cLogP

-5.4854

Hydrogen-bond donors

Hydrogen-bond acceptors

Rotatable bonds

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

IWLTALKFLGKHAAKHLAKQQLSKL

HELM 2.0

validated simple linear

PEPTIDE1{I.W.L.T.A.L.K.F.L.G.K.H.A.A.K.H.L.A.K.Q.Q.L.S.K.L}$$$$V2.0

Canonical SMILES

validated

CCC(C)C(N)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(CC(C)C)C(=O)NC(C(=O)NC(C)C(=O)NC(CC(C)C)C(=O)NC(CCCCN)C(=O)NC(Cc1ccccc1)C(=O)NC(CC(C)C)C(=O)NCC(=O)NC(CCCCN)C(=O)NC(Cc1c[nH]cn1)C(=O)NC(C)C(=O)NC(C)C(=O)NC(CCCCN)C(=O)NC(Cc1c[nH]cn1)C(=O)NC(CC(C)C)C(=O)NC(C)C(=O)NC(CCCCN)C(=O)NC(CCC(N)=O)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)O)C(C)O

Isomeric SMILES

validated

CC[C@H](C)[C@H](N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)O

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.

Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.

Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-028888,
  title = {Lycotoxin-1, M-lycotoxin-Hc1a},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-028888},
  note = {Accessed from local PepDiana development build}
}

APA-style note

Lycotoxin-1, M-lycotoxin-Hc1a. (2026). PepDiana record PEPDIA-INT-028888. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-028888

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (40 records)

Stable record	Activity	Subtype	Value	Target	Assay method	Source
CTPDB_P028888_ACT_apd_0000	Antimicrobial	Anti-Gram+	Not available in the current structured import	Unknown	Not reported by source	AP00516apd / linked
CTPDB_P028888_ACT_apd_0001	Antimicrobial	Antifungal	Not available in the current structured import	Unknown	Not reported by source	AP00516apd / linked
CTPDB_P028888_ACT_apd_0003	Antimicrobial	Insecticidal	Not available in the current structured import	Unknown	Not reported by source	AP00516apd / linked
CTPDB_P028888_ACT_apd_0005	Enzyme Inhibitor	General Enzyme Inhibitor	Not available in the current structured import	Unknown	Not reported by source	AP00516apd / linked
CTPDB_P028888_ACT_arachnoserver_0006	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	65arachnoserver / linked
CTPDB_P028888_ACT_arachnoserver_0007	Antiparasitic	-	Not available in the current structured import	Unknown	Not reported by source	65arachnoserver / linked
CTPDB_P028888_ACT_arachnoserver_0008	Toxicity	Cytotoxic	Not available in the current structured import	Unknown	Not reported by source	65arachnoserver / linked
CTPDB_P028888_ACT_arachnoserver_0009	Neuroactive/Ion Channel	Neurotoxin	Not available in the current structured import	Unknown	Not reported by source	65arachnoserver / linked
CTPDB_P028888_ACT_camp_0011	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ484camp / linked
CTPDB_P028888_ACT_camp_0012	Antimicrobial	Anti-Gram+	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ484camp / linked
CTPDB_P028888_ACT_camp_0013	Antimicrobial	Anti-Gram-	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ484camp / linked
CTPDB_P028888_ACT_dbaasp_0014	Antimicrobial	-	10.0-20.0 µM	Escherichia coli D31 CGSC 5165	Not reported by source	DBAASPS_2296_chain0dbaasp / linked
CTPDB_P028888_ACT_dbaasp_0015	Antimicrobial	-	80.0-150.0 µM	Escherichia coli DH5alpha	Not reported by source	DBAASPS_2296_chain0dbaasp / linked
CTPDB_P028888_ACT_dbaasp_0016	Antimicrobial	-	<5.0 µM	Bacillus thuringiensis serovar israelensis	Not reported by source	DBAASPS_2296_chain0dbaasp / linked
CTPDB_P028888_ACT_dbaasp_0017	Antimicrobial	-	100.0-150.0 µM	Candida glabrata ATCC 2001	Not reported by source	DBAASPS_2296_chain0dbaasp / linked
CTPDB_P028888_ACT_dbaasp_0018	Antimicrobial	-	100.0-200.0 µM	Candida albicans	Not reported by source	DBAASPS_2296_chain0dbaasp / linked
CTPDB_P028888_ACT_dbaasp_0019	Antimicrobial	-	3.1 µM	Staphylococcus aureus USA 300	Not reported by source	DBAASPS_2367_chain0dbaasp / linked
CTPDB_P028888_ACT_dbaasp_0020	Antimicrobial	-	25 µM	Escherichia coli K-12	Not reported by source	DBAASPS_2367_chain0dbaasp / linked
CTPDB_P028888_ACT_dbaasp_0021	Antimicrobial	-	6.25 µM	Bacillus subtilis 168	Not reported by source	DBAASPS_2367_chain0dbaasp / linked
CTPDB_P028888_ACT_dbaasp_0022	Antimicrobial	-	25 µM	Pseudomonas aeruginosa PAO1	Not reported by source	DBAASPS_2367_chain0dbaasp / linked
CTPDB_P028888_ACT_dbaasp_0023	Antimicrobial	-	>35.2 µM	HIV-1 IIIB	Not reported by source	DBAASPS_2367_chain0dbaasp / linked
CTPDB_P028888_ACT_dramp_0024	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	DRAMP03278dramp / linked
CTPDB_P028888_ACT_dramp_0025	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	DRAMP03278dramp / linked
CTPDB_P028888_ACT_dramp_0026	Antimicrobial	Anti-Gram+	Not available in the current structured import	Unknown	Not reported by source	DRAMP03278dramp / linked
CTPDB_P028888_ACT_dramp_0027	Antimicrobial	Anti-Gram-	Not available in the current structured import	Unknown	Not reported by source	DRAMP03278dramp / linked
CTPDB_P028888_ACT_dramp_0028	Antimicrobial	Antifungal	Not available in the current structured import	Unknown	Not reported by source	DRAMP03278dramp / linked
CTPDB_P028888_ACT_dramp_0029	Antimicrobial	Insecticidal	Not available in the current structured import	Unknown	Not reported by source	DRAMP17183dramp / linked
CTPDB_P028888_ACT_dramp_0030	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	DRAMP37296dramp / linked
CTPDB_P028888_ACT_dramp_0031	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	DRAMP37296dramp / linked
CTPDB_P028888_ACT_dramp_0032	Antimicrobial	Anti-Gram+	Not available in the current structured import	Unknown	Not reported by source	DRAMP37296dramp / linked
CTPDB_P028888_ACT_dramp_0033	Antimicrobial	Anti-Gram-	Not available in the current structured import	Unknown	Not reported by source	DRAMP37296dramp / linked
CTPDB_P028888_ACT_hemolytik_0034	Toxicity	Hemolytic	200.0 µM	Erythrocytes	Not reported by source	3384hemolytik / linked
CTPDB_P028888_ACT_hipdb_0010	Antiviral	Anti-HIV	>35.2 μM	HIV	Not reported by source	HIPdb_HIP757hipdb / unavailable
CTPDB_P028888_ACT_satpdb_0035	Antiviral	-	Not available in the current structured import	Unknown	Not reported by source	satpdb14113satpdb / linked
CTPDB_P028888_ACT_satpdb_0036	Toxicity	General Toxic	Not available in the current structured import	Unknown	Not reported by source	satpdb14113satpdb / linked
CTPDB_P028888_ACT_satpdb_0037	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	satpdb14113satpdb / linked
CTPDB_P028888_ACT_satpdb_0038	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	satpdb29178satpdb / linked
CTPDB_P028888_ACT_satpdb_0039	Toxicity	General Toxic	Not available in the current structured import	Unknown	Not reported by source	satpdb29178satpdb / linked
CTPDB_P028888_ACT_satpdb_0040	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	satpdb29178satpdb / linked
CTPDB_P028888_ACT_satpdb_0041	Antimicrobial	Antifungal	Not available in the current structured import	Unknown	Not reported by source	satpdb29178satpdb / linked

Sequence-linked cross-layer evidence

Linked primary-literature evidence

Records

Papers

Positive

Negative

Primary identities

These observations were collected directly from primary literature and linked by identical normalized sequence. They remain a separate evidence layer and do not overwrite Integrated source-database annotations.

View PEPDIA-PLP-003720 View all experimental records

Provenance

Source database records (12)

apd

AP00516

Raw sequence

IWLTALKFLGKHAAKHLAKQQLSKL

arachnoserver

Raw sequence

IWLTALKFLGKHAAKHLAKQQLSKL

hipdb

HIPdb_HIP757

Raw sequence

IWLTALKFLGKHAAKHLAKQQLSKL

camp

CAMPSQ484

Raw sequence

IWLTALKFLGKHAAKHLAKQQLSKL

dbaasp

DBAASPS_2296_chain0

Raw sequence

IWLTALKFLGKHAAKHLAKQQLSKL

dbaasp

DBAASPS_2367_chain0

Raw sequence

IWLTALKFLGKHAAKHLAKQQLSKL

dramp

DRAMP03278

Raw sequence

IWLTALKFLGKHAAKHLAKQQLSKL

dramp

DRAMP17183

Raw sequence

IWLTALKFLGKHAAKHLAKQQLSKL

dramp

DRAMP37296

Raw sequence

IWLTALKFLGKHAAKHLAKQQLSKL

hemolytik

3384

Raw sequence

IWLTALKFLGKHAAKHLAKQQLSKL

satpdb

satpdb14113

Raw sequence

IWLTALKFLGKHAAKHLAKQQLSKL

satpdb

satpdb29178

Raw sequence

IWLTALKFLGKHAAKHLAKQQLSKL

Citation trail

Literature (6 records)

Lycotoxins, Antimicrobial Peptides from Venom of the Wolf Spider Lycosa carolinensis.

Yan L, Adams ME1998

J Biol Chem1998PMID 9442044

{"pubmed_id": "20086159.0", "paper": "Identification of novel human immunodeficiency virus type 1-inhibitory peptides based on the antimicrobial peptide database.", "authors": "Wang G, Watson KM, Peterkofsky A, Buckheit RW Jr.", "reference": "Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. Epub 2010 Jan 19."}

{"pubmed_id": "20086159.0", "paper": "Identification of novel human immunodeficiency virus type 1-inhibitory peptides based on the antimicrobial peptide database.", "authors": "Wang G, Watson KM, Peterkofsky A, Buckheit RW Jr.", "reference": "Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. Epub 2010 Jan 19."}

Database screening and in vivo efficacy of antimicrobial peptides against methicillin-resistant Staphylococcus aureus USA300.

Menousek J, Mishra B, Hanke ML, Heim CE, Kielian T, Wang G

Int J Antimicrob Agents2012PMID 22445495

Database screening and in vivo efficacy of antimicrobial peptides against methicillin-resistant Staphylococcus aureus USA300.

Menousek J, Mishra B, Hanke ML, Heim CE, Kielian T, Wang G

Int J Antimicrob Agents2012PMID 20086159

Lycotoxins, antimicrobial peptides from venom of the wolf spider Lycosa carolinensis.##Membrane structure and interactions of a short Lycotoxin I analogue.

Yan L, Adams ME.##Adão R, Seixas R, Gomes P, Pessoa JC, Bastos M.

J Biol Chem1998PMID 18098329

{"doi": "10.13376/j.cbls/2014156.", "reference": "[J].生命科学,2014,26(10):1090-1095.DOI:10.13376/j.cbls/2014156.", "author": "唐兴,陈连水,李江：TANG Xing CHEN Lian-Shui LI Jiang", "title": "蜘蛛抗菌肽研究进展：Advances in spider antimicrobial peptides"}

{"doi": "10.13376/j.cbls/2014156.", "reference": "[J].生命科学,2014,26(10):1090-1095.DOI:10.13376/j.cbls/2014156.", "author": "唐兴,陈连水,李江：TANG Xing CHEN Lian-Shui LI Jiang", "title": "蜘蛛抗菌肽研究进展：Advances in spider antimicrobial peptides"}

IP evidence

Patents (1)

US 8334366

dramp

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:11.941613+00:00

Modification summary

No structured modification annotations are available for this record.

ADMET

{
  "toxicity": [
    {
      "unit": "µM",
      "value": "200",
      "source_db": "dbaasp",
      "assay_method": "55% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Rabbit erythrocytes"
    },
    {
      "unit": "µM",
      "value": "125",
      "source_db": "dbaasp",
      "assay_method": "50% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Human erythrocytes"
    },
    {
      "unit": "µM",
      "value": "2.4",
      "source_db": "dbaasp",
      "assay_method": "50% Cell death",
      "toxicity_type": "Cytotoxic",
      "target_cellline": "CEM-SS cells"
    }
  ]
}

Source metadata

[
  {
    "source_db": "apd",
    "organism_name": "Unknown"
  },
  {
    "source_db": "arachnoserver",
    "organism_name": "Unknown"
  },
  {
    "source_db": "hipdb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "camp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dbaasp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dramp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "hemolytik",
    "organism_name": "Unknown"
  },
  {
    "source_db": "satpdb",
    "organism_name": "Unknown"
  }
]

Structure metadata

{
  "pdb_id": "Not found",
  "source_db": "dramp"
}