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PEPDIA-INT-025875

Gold

Angiotensin I-converting enzyme inhibitor IV

Quality

Source DBs

Activities

Source refs

Literature

Patents

Integrated record

Sequence and molecular profile

LRIPVA

Indexed sequence6 aa

1LRIPVA

Length

Molecular weight

667.85 Da

Formula

C31H57N9O7

Structure type

Linear

Synthesis

Chirality

Family

Gene

Residue composition

Physicochemical profile

Hydrophobic4

Membrane affinity proxy

Polar0

Solubility proxy

Charged1

Net charge proxy +1

Aromatic0

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

667.8403 Da

Molecular formula

C31H57N9O7

Theoretical pI

9.75

Net charge at pH 7

0.7601

GRAVY

1.3667

Instability index

67.7333

Aromaticity

Topological polar surface area

261.93 Å²

cLogP

-0.6401

Hydrogen-bond donors

Hydrogen-bond acceptors

Rotatable bonds

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

LRIPVA

HELM 2.0

validated simple linear

PEPTIDE1{L.R.I.P.V.A}$$$$V2.0

Canonical SMILES

validated

CCC(C)C(NC(=O)C(CCCNC(=N)N)NC(=O)C(N)CC(C)C)C(=O)N1CCCC1C(=O)NC(C(=O)NC(C)C(=O)O)C(C)C

Isomeric SMILES

validated

CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)O)C(C)C

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.

Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.

Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-025875,
  title = {Angiotensin I-converting enzyme inhibitor IV},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-025875},
  note = {Accessed from local PepDiana development build}
}

APA-style note

Angiotensin I-converting enzyme inhibitor IV. (2026). PepDiana record PEPDIA-INT-025875. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-025875

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (11 records)

Stable record	Activity	Subtype	Value	Target	Assay method	Source
CTPDB_P025875_ACT_ahtpdb_0000	Metabolic/Cardiovascular	ACE Inhibitor	0.38 µM	Unknown	ACE inhibitory assay kit (ACE kit-WST, Dojindo Lab	1023ahtpdb / linked
CTPDB_P025875_ACT_ahtpdb_0001	Metabolic/Cardiovascular	ACE Inhibitor	0.38 µM	Unknown	Cushman and Cheung (1971)	1924ahtpdb / linked
CTPDB_P025875_ACT_ahtpdb_0002	Metabolic/Cardiovascular	ACE Inhibitor	0.38 µM	Unknown	Not reported by source	2298ahtpdb / linked
CTPDB_P025875_ACT_ahtpdb_0003	Metabolic/Cardiovascular	ACE Inhibitor	0.38 µM	Unknown	Cushman and Cheung (1971), Maruyama and Suzuki	2575ahtpdb / linked
CTPDB_P025875_ACT_ahtpdb_0004	Metabolic/Cardiovascular	ACE Inhibitor	0.38 µM	Unknown	Not reported by source	5369ahtpdb / linked
CTPDB_P025875_ACT_ahtpdb_0005	Metabolic/Cardiovascular	ACE Inhibitor	0.38 µM	Unknown	Cushman and Cheung (1971)	6230ahtpdb / linked
CTPDB_P025875_ACT_plantpepdb_0006	Metabolic/Cardiovascular	Antihypertensive	Not available for this observation	Unknown	Not reported by source	PPepDB_3834plantpepdb / linked
CTPDB_P025875_ACT_plantpepdb_0007	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Not reported by source	PPepDB_3834plantpepdb / linked
CTPDB_P025875_ACT_plantpepdb_0008	Enzyme Inhibitor	General Enzyme Inhibitor	Not available in the current structured import	Unknown	Not reported by source	PPepDB_3834plantpepdb / linked
CTPDB_P025875_ACT_plantpepdb_0009	Antioxidant	-	Not available in the current structured import	Unknown	Not reported by source	PPepDB_3834plantpepdb / linked
CTPDB_P025875_ACT_satpdb_0010	Metabolic/Cardiovascular	Antihypertensive	Not available for this observation	Unknown	Not reported by source	satpdb16401satpdb / linked

Sequence-linked cross-layer evidence

Linked primary-literature evidence

Records

Papers

Positive

Negative

Primary identities

These observations were collected directly from primary literature and linked by identical normalized sequence. They remain a separate evidence layer and do not overwrite Integrated source-database annotations.

View PEPDIA-PLP-003857 View all experimental records

Provenance

Source database records (8)

ahtpdb

2298

Raw sequence

LRIPVA

ahtpdb

2575

Raw sequence

LRIPVA

ahtpdb

1023

Raw sequence

LRIPVA

ahtpdb

1924

Raw sequence

LRIPVA

ahtpdb

6230

Raw sequence

LRIPVA

ahtpdb

5369

Raw sequence

LRIPVA

plantpepdb

PPepDB_3834

Raw sequence

LRIPVA

satpdb

satpdb16401

Raw sequence

LRIPVA

Citation trail

Literature (9 records)

A new QSAR model, for angiotensin I-converting enzyme inhibitory oligopeptides.

Sagardia I1, Roa-Ureta RH, Bald C.

Food Chem. 2013 Feb 15;136(3-4):1370-6.2013PMID 23194537

ISOLATION AND CHARACTERIZATION OF PEPTIDES WITH ANTIHYPERTENSIVE ACTIVITY IN FOODSTUFFS.

Puchalska P1, Alegre ML, López MC.

Crit Rev Food Sci Nutr. 2013 Sep 2.2013PMID 24915368

Novel angiotensin I-converting enzyme inhibitory peptides derived from an edible mushroom, Pleurotus cystidiosus O.K. Miller identified by LC-MS/MS

Ching Ching Lau1, Noorlidah Abdullah1* and Adawiyah Suriza Shuib

BMC Complementary and Alternative Medicine 2013, 13:3132013PMID 24215325

Vegetable foods: A cheap source of proteins and peptides with antihypertensive, antioxidant, and other less occurrence bioactivities.

M C García, P Puchalska, C Esteve, M L Marina

Talanta 03/2013; 106C:328-349.2013PMID 23598136

Isolation and Antihypertensive Effect of Angiotensin I-Converting Enzyme (ACE) Inhibitory Peptides from Spinach Rubisco

Yang, Y. et al.,

Isolation and Antihypertensive Effect of Angiotensin I-Converting Enzyme (ACE) Inhibitory Peptides from Spinach Rubisco2003PMID 12903942

Integration of QSAR modelling and QM/MM analysis to investigate functional food peptides with antihypertensive activity

Jin Tan et al.

Molecular Simulation Volume 39, Issue 12, 20132013

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:11.113046+00:00

Modification summary

No structured modification annotations are available for this record.

Source metadata

[
  {
    "source_db": "ahtpdb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "plantpepdb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "satpdb",
    "organism_name": "Unknown"
  }
]

Structure metadata

{
  "source_db": "satpdb",
  "dssp_states": "CCCSCC"
}