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PEPDIA-INT-025256

Gold

Angiotensin I-converting enzyme inhibitor I

Quality

Source DBs

Activities

Source refs

Literature

Patents

Integrated record

Sequence and molecular profile

IAYKPAG

Indexed sequence7 aa

1IAYKPAG

Length

Molecular weight

718.85 Da

Formula

C34H54N8O9

Structure type

Linear

Synthesis

Chirality

Family

Gene

Residue composition

Physicochemical profile

Hydrophobic4

Membrane affinity proxy

Polar0

Solubility proxy

Charged1

Net charge proxy +1

Aromatic1

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

718.8407 Da

Molecular formula

C34H54N8O9

Theoretical pI

8.5909

Net charge at pH 7

0.7581

GRAVY

0.1286

Instability index

25.3143

Aromaticity

0.1429

Topological polar surface area

275.38 Å²

cLogP

-1.3921

Hydrogen-bond donors

Hydrogen-bond acceptors

Rotatable bonds

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

IAYKPAG

HELM 2.0

validated simple linear

PEPTIDE1{I.A.Y.K.P.A.G}$$$$V2.0

Canonical SMILES

validated

CCC(C)C(N)C(=O)NC(C)C(=O)NC(Cc1ccc(O)cc1)C(=O)NC(CCCCN)C(=O)N1CCCC1C(=O)NC(C)C(=O)NCC(=O)O

Isomeric SMILES

validated

CC[C@H](C)[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)NCC(=O)O

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.

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Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-025256,
  title = {Angiotensin I-converting enzyme inhibitor I},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-025256},
  note = {Accessed from local PepDiana development build}
}

APA-style note

Angiotensin I-converting enzyme inhibitor I. (2026). PepDiana record PEPDIA-INT-025256. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-025256

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (8 records)

Stable record	Activity	Subtype	Value	Target	Assay method	Source
CTPDB_P025256_ACT_ahtpdb_0000	Metabolic/Cardiovascular	ACE Inhibitor	4.17 µM	Unknown	Not reported by source	2329ahtpdb / linked
CTPDB_P025256_ACT_ahtpdb_0001	Metabolic/Cardiovascular	ACE Inhibitor	4.2 µM	Unknown	Cushman and Cheung (1971), Maruyama and Suzuki	2576ahtpdb / linked
CTPDB_P025256_ACT_ahtpdb_0002	Metabolic/Cardiovascular	ACE Inhibitor	4.2 µM	Unknown	Cushman and Cheung (1971)	6227ahtpdb / linked
CTPDB_P025256_ACT_plantpepdb_0003	Enzyme Inhibitor	General Enzyme Inhibitor	Not available in the current structured import	Unknown	Not reported by source	PPepDB_2969plantpepdb / linked
CTPDB_P025256_ACT_plantpepdb_0004	Antioxidant	-	Not available in the current structured import	Unknown	Not reported by source	PPepDB_2969plantpepdb / linked
CTPDB_P025256_ACT_plantpepdb_0005	Metabolic/Cardiovascular	Antihypertensive	Not available for this observation	Unknown	Not reported by source	PPepDB_2969plantpepdb / linked
CTPDB_P025256_ACT_plantpepdb_0006	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Not reported by source	PPepDB_2969plantpepdb / linked
CTPDB_P025256_ACT_satpdb_0007	Metabolic/Cardiovascular	Antihypertensive	Not available for this observation	Unknown	Not reported by source	satpdb15752satpdb / linked

Sequence-linked cross-layer evidence

Linked primary-literature evidence

Records

Papers

Positive

Negative

Primary identities

These observations were collected directly from primary literature and linked by identical normalized sequence. They remain a separate evidence layer and do not overwrite Integrated source-database annotations.

View PEPDIA-PLP-003650 View all experimental records

Provenance

Source database records (5)

ahtpdb

2329

Raw sequence

IAYKPAG

ahtpdb

2576

Raw sequence

IAYKPAG

ahtpdb

6227

Raw sequence

IAYKPAG

plantpepdb

PPepDB_2969

Raw sequence

IAYKPAG

satpdb

satpdb15752

Raw sequence

IAYKPAG

Citation trail

Literature (5 records)

A new QSAR model, for angiotensin I-converting enzyme inhibitory oligopeptides.

Sagardia I1, Roa-Ureta RH, Bald C.

Food Chem. 2013 Feb 15;136(3-4):1370-6.2013PMID 23194537

ISOLATION AND CHARACTERIZATION OF PEPTIDES WITH ANTIHYPERTENSIVE ACTIVITY IN FOODSTUFFS.

Puchalska P1, Alegre ML, López MC.

Crit Rev Food Sci Nutr. 2013 Sep 2.2013PMID 24915368

Isolation and Antihypertensive Effect of Angiotensin I-Converting Enzyme (ACE) Inhibitory Peptides from Spinach Rubisco

Yang, Y. et al.,

Isolation and Antihypertensive Effect of Angiotensin I-Converting Enzyme (ACE) Inhibitory Peptides from Spinach Rubisco2003PMID 12903942

-

--PMID 28333109

-

--PMID 28317757

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:11.113046+00:00

Modification summary

No structured modification annotations are available for this record.

Source metadata

[
  {
    "source_db": "ahtpdb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "plantpepdb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "satpdb",
    "organism_name": "Unknown"
  }
]

Structure metadata

{
  "source_db": "satpdb",
  "dssp_states": "CTTCSCC"
}