ProForma 2.0
validated simple linear
EF
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PEPDIA-INT-017952
SilverPepDiana tier derived from the internal quality score plus activity and literature coverage; it is not an external database rating.EF
65
Quality PepDiana 0–100 composite of sequence, source, activity, literature, and cross-database evidence completeness.
4
Source DBs
6
Activities
4
Source refs
2
Literature
0
Patents
Integrated record
Sequence and molecular profile
EF
Indexed sequence2 aa
1EF
Length
2
Molecular weight
294.31 Da
Formula
C14H18N2O5
Structure type
Linear
Synthesis
Synthetic
Chirality
L
Family
-
Gene
-
Residue composition
E
1
F
1
Physicochemical profile
Hydrophobic1
Membrane affinity proxy
Polar0
Solubility proxy
Charged1
Net charge proxy -1
Aromatic1
Binding interaction proxy
Versioned scientific descriptors
Physicochemical properties and standard representations
Reported properties
Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.
Computed properties
physchem-20260620Molecular weight
294.3031 Da
Molecular formula
C14H18N2O5
Theoretical pI
4.05
Net charge at pH 7
-1.1632
GRAVY
-0.35
Instability index
5
Aromaticity
0.5
Topological polar surface area
129.72 Ų
cLogP
-0.0094
Hydrogen-bond donors
4
Hydrogen-bond acceptors
4
Rotatable bonds
8
Method: PepDiana sequence/structure descriptor pipeline
Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6
Calculated: 2026-06-20T11:01:38.358971+00:00
Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200
Sequence representations
HELM 2.0
validated simple linear
PEPTIDE1{E.F}$$$$V2.0
Canonical SMILES
validated
NC(CCC(=O)O)C(=O)NC(Cc1ccccc1)C(=O)O
Isomeric SMILES
validated
N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
Follow-up research
External analysis tools
Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.
Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.
Research workflow
Citation and local history
BibTeX
@misc{PEPDIA-INT-017952,
title = {EF},
author = {{PepDiana Consortium}},
year = {2026},
howpublished = {PepDiana Multifunctional Peptide Database},
url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-017952},
note = {Accessed from local PepDiana development build}
}APA-style note
EF. (2026). PepDiana record PEPDIA-INT-017952. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-017952
This record is saved to local recent-view history so it can reappear on the peptide browser page.
Integrated source-database annotations
Biological activity (6 records)
| Stable record | Activity | Subtype | Value | Target | Assay method | Source |
|---|---|---|---|---|---|---|
| CTPDB_P017952_ACT_camp_0000 | Antimicrobial | Anti-Gram+ | Not available in the current structured import | Unknown | Not reported by source | CAMPSQ24027camp / linked |
| CTPDB_P017952_ACT_dbaasp_0001 | Antimicrobial | - | 96 µM | DENV-2 | Not reported by source | DBAASPS_15502_chain0dbaasp / linked |
| CTPDB_P017952_ACT_dbaasp_0002 | Antimicrobial | - | 200 µM | DENV-2 | Not reported by source | DBAASPS_15502_chain0dbaasp / linked |
| CTPDB_P017952_ACT_dramp_0003 | Antimicrobial | - | Not available in the current structured import | Unknown | Not reported by source | DRAMP31481dramp / linked |
| CTPDB_P017952_ACT_dramp_0004 | Antiviral | - | Not available in the current structured import | Unknown | Not reported by source | DRAMP31481dramp / linked |
| CTPDB_P017952_ACT_plantpepdb_0005 | Metabolic/Cardiovascular | ACE Inhibitor | Not available in the current structured import | Unknown | Not reported by source | PPepDB_3133plantpepdb / linked |
Sequence-linked cross-layer evidence
Linked primary-literature evidence
1
Records
1
Papers
1
Positive
0
Negative
1
Primary identities
These observations were collected directly from primary literature and linked by identical normalized sequence. They remain a separate evidence layer and do not overwrite Integrated source-database annotations.
Provenance
Source database records (4)
Citation trail
Literature (2 records)
-
-
-
-
Audit surface
Raw annotations and release metadata
Integrated record last updated: 2026-04-15T00:59:16.160600+00:00
Modification summary
No structured modification annotations are available for this record.
ADMET
{
"toxicity": [
{
"unit": "µM",
"value": "500",
"source_db": "dbaasp",
"assay_method": "0% Cytotoxicity",
"toxicity_type": "Cytotoxic",
"target_cellline": "Vero cells"
},
{
"unit": "µM",
"source_db": "dramp",
"assay_method": "[Ref.24612829]No cytotoxicity against Vero cells up to 500 µM.",
"toxicity_type": "Cytotoxic"
}
]
}Source metadata
[
{
"source_db": "camp",
"organism_name": "Unknown"
},
{
"source_db": "dbaasp",
"organism_name": "Unknown"
},
{
"source_db": "dramp",
"organism_name": "Unknown"
},
{
"source_db": "plantpepdb",
"organism_name": "Unknown"
}
]