ProForma 2.0
validated simple linear
FLQRIIGALGRLF
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PEPDIA-INT-010874
SilverPepDiana tier derived from the internal quality score plus activity and literature coverage; it is not an external database rating.temporin-GHaR
60
Quality PepDiana 0–100 composite of sequence, source, activity, literature, and cross-database evidence completeness.
1
Source DBs
5
Activities
1
Source refs
1
Literature
0
Patents
Integrated record
Sequence and molecular profile
FLQRIIGALGRLF
Indexed sequence13 aa
1FLQRIIGALGRLF
Length
13
Molecular weight
1503.86 Da
Formula
C72H118N20O15
Structure type
Linear
Synthesis
-
Chirality
L
Family
-
Gene
-
Residue composition
L
3
F
2
R
2
I
2
G
2
Q
1
A
1
Physicochemical profile
Hydrophobic8
Membrane affinity proxy
Polar1
Solubility proxy
Charged2
Net charge proxy +2
Aromatic2
Binding interaction proxy
Versioned scientific descriptors
Physicochemical properties and standard representations
Reported properties
Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.
Computed properties
physchem-20260620Molecular weight
1503.832 Da
Molecular formula
C72H118N20O15
Theoretical pI
12
Net charge at pH 7
1.7601
GRAVY
1.1154
Instability index
27.7769
Aromaticity
0.1538
Topological polar surface area
579.41 Ų
cLogP
-1.9935
Hydrogen-bond donors
21
Hydrogen-bond acceptors
17
Rotatable bonds
50
Method: PepDiana sequence/structure descriptor pipeline
Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6
Calculated: 2026-06-20T11:01:38.358971+00:00
Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200
Sequence representations
HELM 2.0
validated simple linear
PEPTIDE1{F.L.Q.R.I.I.G.A.L.G.R.L.F}$$$$V2.0
Canonical SMILES
validated
CCC(C)C(NC(=O)C(CCCNC(=N)N)NC(=O)C(CCC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(N)Cc1ccccc1)C(=O)NC(C(=O)NCC(=O)NC(C)C(=O)NC(CC(C)C)C(=O)NCC(=O)NC(CCCNC(=N)N)C(=O)NC(CC(C)C)C(=O)NC(Cc1ccccc1)C(=O)O)C(C)CC
Isomeric SMILES
validated
CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC
Follow-up research
External analysis tools
Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.
Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.
Research workflow
Citation and local history
BibTeX
@misc{PEPDIA-INT-010874,
title = {temporin-GHaR},
author = {{PepDiana Consortium}},
year = {2026},
howpublished = {PepDiana Multifunctional Peptide Database},
url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-010874},
note = {Accessed from local PepDiana development build}
}APA-style note
temporin-GHaR. (2026). PepDiana record PEPDIA-INT-010874. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-010874
This record is saved to local recent-view history so it can reappear on the peptide browser page.
Integrated source-database annotations
Biological activity (5 records)
| Stable record | Activity | Subtype | Value | Target | Assay method | Source |
|---|---|---|---|---|---|---|
| CTPDB_P010874_ACT_dramp_0000 | Antimicrobial | - | Not available in the current structured import | Unknown | Not reported by source | DRAMP29059dramp / linked |
| CTPDB_P010874_ACT_dramp_0001 | Antimicrobial | Antibacterial | Not available in the current structured import | Unknown | Not reported by source | DRAMP29059dramp / linked |
| CTPDB_P010874_ACT_dramp_0002 | Antimicrobial | Anti-Gram+ | Not available in the current structured import | Unknown | Not reported by source | DRAMP29059dramp / linked |
| CTPDB_P010874_ACT_dramp_0003 | Antimicrobial | Anti-Gram- | Not available in the current structured import | Unknown | Not reported by source | DRAMP29059dramp / linked |
| CTPDB_P010874_ACT_dramp_0004 | Antimicrobial | Antifungal | Not available in the current structured import | Unknown | Not reported by source | DRAMP29059dramp / linked |
Sequence-linked cross-layer evidence
Linked primary-literature evidence
11
Records
1
Papers
11
Positive
0
Negative
1
Primary identities
These observations were collected directly from primary literature and linked by identical normalized sequence. They remain a separate evidence layer and do not overwrite Integrated source-database annotations.
Provenance
Source database records (1)
Citation trail
Literature (1 records)
Temporin-Like Peptides Show Antimicrobial and Anti-Biofilm Activities against Streptococcus mutans with Reduced Hemolysis
Wei H, Xie Z, Tan X, Guo R, Song Y, Xie X, Wang R, Li L, Wang M, Zhang Y
Audit surface
Raw annotations and release metadata
Integrated record last updated: 2026-04-15T00:59:18.807474+00:00
Modification summary
No structured modification annotations are available for this record.
ADMET
{
"toxicity": [
{
"unit": "µM",
"source_db": "dramp",
"assay_method": "[Ref.33291521]HL50 = 48μM against human red blood cells (hRBCs)",
"toxicity_type": "Hemolytic",
"target_cellline": "Erythrocytes"
}
]
}Source metadata
[
{
"source_db": "dramp",
"organism_name": "Unknown"
}
]