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PEPDIA-INT-006336

Gold

Unnamed peptide

85

Quality

3

Source DBs

31

Activities

34

Source refs

10

Literature

0

Patents

Integrated record

Sequence and molecular profile

DKIHPF
Indexed sequence6 aa
1DKIHPF

Length

6

Molecular weight

755.87 Da

Formula

C36H53N9O9

Structure type

Linear

Synthesis

-

Chirality

-

Family

-

Gene

-

Residue composition

D
1
K
1
I
1
H
1
P
1
F
1

Physicochemical profile

Hydrophobic2

Membrane affinity proxy

Polar0

Solubility proxy

Charged3

Net charge proxy +1

Aromatic2

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

755.8609 Da

Molecular formula

C36H53N9O9

Theoretical pI

6.7436

Net charge at pH 7

-0.1526

GRAVY

-0.8167

Instability index

27.9

Aromaticity

0.1667

Topological polar surface area

292.03 Ų

cLogP

-0.8132

Hydrogen-bond donors

9

Hydrogen-bond acceptors

10

Rotatable bonds

22

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

DKIHPF

HELM 2.0

validated simple linear

PEPTIDE1{D.K.I.H.P.F}$$$$V2.0

Canonical SMILES

validated

CCC(C)C(NC(=O)C(CCCCN)NC(=O)C(N)CC(=O)O)C(=O)NC(Cc1c[nH]cn1)C(=O)N1CCCC1C(=O)NC(Cc1ccccc1)C(=O)O

Isomeric SMILES

validated

CC[C@H](C)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.

Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.

Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-006336,
  title = {Unnamed peptide},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-006336},
  note = {Accessed from local PepDiana development build}
}

APA-style note

Unnamed peptide. (2026). PepDiana record PEPDIA-INT-006336. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-006336

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (31 records)

Stable recordActivitySubtypeValueTargetAssay methodSource
CTPDB_P006336_ACT_ahtpdb_0002Metabolic/CardiovascularACE Inhibitor419.91 µMUnknownNot reported by source2490ahtpdb / linked
CTPDB_P006336_ACT_ahtpdb_0003Metabolic/CardiovascularACE InhibitorNot available for this observationUnknownNot reported by source3408ahtpdb / linked
CTPDB_P006336_ACT_ahtpdb_0004Metabolic/CardiovascularACE Inhibitor256.8 µMUnknownCushman and Cheung (1971)3649ahtpdb / linked
CTPDB_P006336_ACT_ahtpdb_0000Metabolic/CardiovascularACE InhibitorNot available for this observationUnknownNot reported by source4291ahtpdb / linked
CTPDB_P006336_ACT_ahtpdb_0001Metabolic/CardiovascularACE Inhibitor2419.4 µMUnknownCushman and Cheung (1971)4314ahtpdb / linked
CTPDB_P006336_ACT_ahtpdb_0005Metabolic/CardiovascularACE Inhibitor1000.0 µMUnknownCushman and Cheung (1971)5929ahtpdb / linked
CTPDB_P006336_ACT_ahtpdb_0006Metabolic/CardiovascularACE Inhibitor256.8 µMUnknownCushman and Cheung (1971)5957ahtpdb / linked
CTPDB_P006336_ACT_ahtpdb_0007Metabolic/CardiovascularACE InhibitorNot available for this observationUnknownHolmquist et al. (1979)6058ahtpdb / linked
CTPDB_P006336_ACT_ahtpdb_0008Metabolic/CardiovascularACE Inhibitor257.0 µMUnknownNot reported by source6503ahtpdb / linked
CTPDB_P006336_ACT_fermfoodb_0009Metabolic/CardiovascularAntihypertensiveNot available for this observationUnknownLC-MS with Q Exactive Plus hybridquadrupole-Orbitrap mass spectrometerFermFooDB_Casein_FMDB1806fermfoodb / linked
CTPDB_P006336_ACT_fermfoodb_0010Metabolic/CardiovascularAntihypertensiveNot available for this observationUnknownLC-MS with Q Exactive Plus hybridquadrupole-Orbitrap mass spectrometerFermFooDB_Casein_FMDB1807fermfoodb / linked
CTPDB_P006336_ACT_fermfoodb_0011Metabolic/CardiovascularAntihypertensiveNot available for this observationUnknownLC-MS with Q Exactive Plus hybridquadrupole-Orbitrap mass spectrometerFermFooDB_Casein_FMDB1808fermfoodb / linked
CTPDB_P006336_ACT_fermfoodb_0012Metabolic/CardiovascularAntihypertensiveNot available for this observationUnknownLC-MS with Q Exactive Plus hybridquadrupole-Orbitrap mass spectrometerFermFooDB_Casein_FMDB1809fermfoodb / linked
CTPDB_P006336_ACT_fermfoodb_0013Metabolic/CardiovascularACE Inhibitor2419.4 µMUnknownRP-HPLC-MS/MS and off-line ESI-MS/MSFermFooDB_Cheese_FMDB1598fermfoodb / linked
CTPDB_P006336_ACT_fermfoodb_0014Metabolic/CardiovascularACE Inhibitor2419.4 µMUnknownRP-HPLC-MS/MS and off-line ESI-MS/MSFermFooDB_Cheese_FMDB1618fermfoodb / linked
CTPDB_P006336_ACT_fermfoodb_0015Metabolic/CardiovascularACE Inhibitor2419.4 µMUnknownRP-HPLC-MS/MS and off-line ESI-MS/MSFermFooDB_Cheese_FMDB1623fermfoodb / linked
CTPDB_P006336_ACT_fermfoodb_0016Metabolic/CardiovascularACE Inhibitor2419.4 µMUnknownRP-HPLC-MS/MS and off-line ESI-MS/MSFermFooDB_Cheese_FMDB1634fermfoodb / linked
CTPDB_P006336_ACT_fermfoodb_0017Metabolic/CardiovascularACE Inhibitor2419.4 µMUnknownRP-HPLC-MS/MS and off-line ESI-MS/MSFermFooDB_Cheese_FMDB1647fermfoodb / linked
CTPDB_P006336_ACT_fermfoodb_0018Metabolic/CardiovascularACE Inhibitor0.14 mg/mlUnknownRPHPLC; Edman degradation method using protein sequencer and MALDI-TOF-MSFermFooDB_Cheese_FMDB865fermfoodb / linked
CTPDB_P006336_ACT_fermfoodb_0019Metabolic/CardiovascularACE Inhibitor0.12 mg/mlUnknownRPHPLC; Edman degradation method using protein sequencer and MALDI-TOF-MSFermFooDB_Cheese_FMDB872fermfoodb / linked
CTPDB_P006336_ACT_fermfoodb_0020Metabolic/CardiovascularACE Inhibitor0.16 mg/mlUnknownRPHPLC; Edman degradation method using protein sequencer and MALDI-TOF-MSFermFooDB_Cheese_FMDB879fermfoodb / linked
CTPDB_P006336_ACT_fermfoodb_0029Antioxidant-Not available in the current structured importUnknownLC-MS/MSFermFooDB_Yogurt_FMDB1307fermfoodb / linked
CTPDB_P006336_ACT_fermfoodb_0028Metabolic/CardiovascularACE InhibitorNot available for this observationUnknownLC-MS/MSFermFooDB_milk_FMDB1253fermfoodb / linked
CTPDB_P006336_ACT_fermfoodb_0027Metabolic/CardiovascularACE Inhibitor2419.4 µMUnknownRP-HPLC-MS/MS and off-line ESI-MS/MSFermFooDB_milk_FMDB1618fermfoodb / linked
CTPDB_P006336_ACT_fermfoodb_0026Metabolic/CardiovascularACE Inhibitor2419.4 µMUnknownRP-HPLC-MS/MS and off-line ESI-MS/MSFermFooDB_milk_FMDB1623fermfoodb / linked
CTPDB_P006336_ACT_fermfoodb_0025Metabolic/CardiovascularACE Inhibitor2419.4 µMUnknownRP-HPLC-MS/MS and off-line ESI-MS/MSFermFooDB_milk_FMDB1647fermfoodb / linked
CTPDB_P006336_ACT_fermfoodb_0024Metabolic/CardiovascularAntihypertensiveNot available for this observationUnknownLC-MS with Q Exactive Plus hybridquadrupole-Orbitrap mass spectrometerFermFooDB_milk_FMDB1806fermfoodb / linked
CTPDB_P006336_ACT_fermfoodb_0023Metabolic/CardiovascularAntihypertensiveNot available for this observationUnknownLC-MS with Q Exactive Plus hybridquadrupole-Orbitrap mass spectrometerFermFooDB_milk_FMDB1807fermfoodb / linked
CTPDB_P006336_ACT_fermfoodb_0022Metabolic/CardiovascularAntihypertensiveNot available for this observationUnknownLC-MS with Q Exactive Plus hybridquadrupole-Orbitrap mass spectrometerFermFooDB_milk_FMDB1808fermfoodb / linked
CTPDB_P006336_ACT_fermfoodb_0021Metabolic/CardiovascularACE Inhibitor256.8 µMUnknownFABMSFermFooDB_milk_FMDB70fermfoodb / linked
CTPDB_P006336_ACT_satpdb_0030Metabolic/CardiovascularAntihypertensiveNot available for this observationUnknownNot reported by sourcesatpdb22634satpdb / linked

Sequence-linked cross-layer evidence

Linked primary-literature evidence

1

Records

1

Papers

1

Positive

0

Negative

1

Primary identities

These observations were collected directly from primary literature and linked by identical normalized sequence. They remain a separate evidence layer and do not overwrite Integrated source-database annotations.

View PEPDIA-PLP-003447View all experimental records

Provenance

Source database records (34)

ahtpdb

4291

Raw sequence

DKIHPF

ahtpdb

4314

Raw sequence

DKIHPF

ahtpdb

2490

Raw sequence

DKIHPF

ahtpdb

6058

Raw sequence

DKIHPF

ahtpdb

6503

Raw sequence

DKIHPF

ahtpdb

5929

Raw sequence

DKIHPF

ahtpdb

5957

Raw sequence

DKIHPF

ahtpdb

3408

Raw sequence

DKIHPF

ahtpdb

3649

Raw sequence

DKIHPF

fermfoodb

FermFooDB_Casein_FMDB1695

Raw sequence

DKIHPF

fermfoodb

FermFooDB_Casein_FMDB1806

Raw sequence

DKIHPF

fermfoodb

FermFooDB_Casein_FMDB1807

Raw sequence

DKIHPF

fermfoodb

FermFooDB_Casein_FMDB1808

Raw sequence

DKIHPF

fermfoodb

FermFooDB_Casein_FMDB1809

Raw sequence

DKIHPF

fermfoodb

FermFooDB_Casein_FMDB2157

Raw sequence

DKIHPF

fermfoodb

FermFooDB_Cheese_FMDB1598

Raw sequence

DKIHPF

fermfoodb

FermFooDB_Cheese_FMDB1618

Raw sequence

DKIHPF

fermfoodb

FermFooDB_Cheese_FMDB1623

Raw sequence

DKIHPF

fermfoodb

FermFooDB_Cheese_FMDB1634

Raw sequence

DKIHPF

fermfoodb

FermFooDB_Cheese_FMDB1647

Raw sequence

DKIHPF

fermfoodb

FermFooDB_Cheese_FMDB865

Raw sequence

DKIHPF

fermfoodb

FermFooDB_Cheese_FMDB872

Raw sequence

DKIHPF

fermfoodb

FermFooDB_Cheese_FMDB879

Raw sequence

DKIHPF

fermfoodb

FermFooDB_milk_FMDB70

Raw sequence

DKIHPF

fermfoodb

FermFooDB_milk_FMDB1808

Raw sequence

DKIHPF

fermfoodb

FermFooDB_milk_FMDB1807

Raw sequence

DKIHPF

fermfoodb

FermFooDB_milk_FMDB1806

Raw sequence

DKIHPF

fermfoodb

FermFooDB_milk_FMDB1647

Raw sequence

DKIHPF

fermfoodb

FermFooDB_milk_FMDB1623

Raw sequence

DKIHPF

fermfoodb

FermFooDB_milk_FMDB1618

Raw sequence

DKIHPF

fermfoodb

FermFooDB_milk_FMDB1253

Raw sequence

DKIHPF

fermfoodb

FermFooDB_Yogurt_FMDB1307

Raw sequence

DKIHPF

fermfoodb

FermFooDB_Yogurt_FMDB2132

Raw sequence

DKIHPF

satpdb

satpdb22634

Raw sequence

DKIHPF

Citation trail

Literature (10 records)

Bioactive Peptides of Buffalo, Camel, Goat, Sheep, Mare, and Yak Milks and Milk Products

M. H. Abd El-Salama & S. El-Shibinya

Food Reviews International Volume 29, Issue 1, 20132013

A new QSAR model, for angiotensin I-converting enzyme inhibitory oligopeptides.

Sagardia I1, Roa-Ureta RH, Bald C.

Food Chem. 2013 Feb 15;136(3-4):1370-6.2013PMID 23194537

Identification of angiotensin-I-converting enzyme inhibitory peptides derived from sodium caseinate hydrolysates produced by Lactobacillus helveticus NCC 2765

Robert, M.C. Et al.,

J Agric Food Chem 52 p.6923-312004PMID 15537298

Biochemical and Functional Characterisation of Casein and Whey Protein Hydrolysates: A Study on the Correlations Between Biochemical and Functional Properties Using Multivariate Data Analysis

Cornelly van der Ven

Publisher Wageningen Universiteit2002

Angiotensin-converting enzyme inhibitory activity of peptides derived from caprine kefir

Quiros, A. et al.,

Dairy Sci 88 p.3480-72005PMID 16162521

Production of angiotensin-1-converting enzyme inhibitory peptides in fermented milks started by Lactobacillus delbruekii subsp bulgaricus SS1 and Lactococcus lactis subsp cremoris FT5

Gobbetti, M. et al.,

Appl Environ Microbiol 66 p.3898-39042000

Animal and Plant Proteins as Precursors of Peptides with ACE Inhibitory Activity – An in silico Strategy of Protein Evaluation

Anna Iwaniak and Jerzy Dziuba

Food Technol. Biotechnol. 47 (4) 441–449 (2009)2009

Lactic Fermentation and Bioactive Peptides

Anne Pihlanto

Lactic Acid Bacteria - R & D for Food, Health and Livestock Purposes Edited by Marcelino Kongo, ISBN 978-953-51-0955-6, 670 pages,2013

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:10.991164+00:00

Modification summary

No structured modification annotations are available for this record.

Source metadata
[
  {
    "source_db": "ahtpdb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "fermfoodb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "satpdb",
    "organism_name": "Unknown"
  }
]
Structure metadata
{
  "source_db": "satpdb",
  "dssp_states": "CCSCCC"
}