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PEPDIA-INT-004795

Gold

Bitter peptide, cyclo[Gly-Ala] or cyclo[Ala-Gly]

Quality

Source DBs

Activities

Source refs

Literature

Patents

Integrated record

Sequence and molecular profile

Indexed sequence2 aa

1GA

Length

Molecular weight

146.15 Da

Formula

C5H10N2O3

Structure type

Linear

Synthesis

Chirality

Family

Gene

Residue composition

Physicochemical profile

Hydrophobic1

Membrane affinity proxy

Polar0

Solubility proxy

Charged0

Net charge proxy +0

Aromatic0

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

146.1445 Da

Molecular formula

C5H10N2O3

Theoretical pI

5.525

Net charge at pH 7

-0.2399

GRAVY

0.7

Instability index

-37.45

Aromaticity

Topological polar surface area

92.42 Å²

cLogP

-1.4656

Hydrogen-bond donors

Hydrogen-bond acceptors

Rotatable bonds

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

HELM 2.0

validated simple linear

PEPTIDE1{G.A}$$$$V2.0

Canonical SMILES

validated

CC(NC(=O)CN)C(=O)O

Isomeric SMILES

validated

C[C@H](NC(=O)CN)C(=O)O

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.

Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.

Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-004795,
  title = {Bitter peptide, cyclo[Gly-Ala] or cyclo[Ala-Gly]},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-004795},
  note = {Accessed from local PepDiana development build}
}

APA-style note

Bitter peptide, cyclo[Gly-Ala] or cyclo[Ala-Gly]. (2026). PepDiana record PEPDIA-INT-004795. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-004795

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (19 records)

Stable record	Activity	Subtype	Value	Target	Assay method	Source
CTPDB_P004795_ACT_ahtpdb_0003	Metabolic/Cardiovascular	ACE Inhibitor	20.0 mM	Unknown	Not reported by source	1424ahtpdb / linked
CTPDB_P004795_ACT_ahtpdb_0004	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Not reported by source	1685ahtpdb / linked
CTPDB_P004795_ACT_ahtpdb_0005	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Not reported by source	3013ahtpdb / linked
CTPDB_P004795_ACT_ahtpdb_0006	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Not reported by source	3035ahtpdb / linked
CTPDB_P004795_ACT_ahtpdb_0007	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Not reported by source	3057ahtpdb / linked
CTPDB_P004795_ACT_ahtpdb_0008	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Not reported by source	3088ahtpdb / linked
CTPDB_P004795_ACT_ahtpdb_0009	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Not reported by source	3093ahtpdb / linked
CTPDB_P004795_ACT_ahtpdb_0010	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Not reported by source	3128ahtpdb / linked
CTPDB_P004795_ACT_ahtpdb_0011	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Not reported by source	3233ahtpdb / linked
CTPDB_P004795_ACT_ahtpdb_0012	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Not reported by source	3482ahtpdb / linked
CTPDB_P004795_ACT_ahtpdb_0013	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Not reported by source	3802ahtpdb / linked
CTPDB_P004795_ACT_ahtpdb_0014	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Not reported by source	3914ahtpdb / linked
CTPDB_P004795_ACT_ahtpdb_0000	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Not reported by source	4422ahtpdb / linked
CTPDB_P004795_ACT_ahtpdb_0001	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Not reported by source	4508ahtpdb / linked
CTPDB_P004795_ACT_ahtpdb_0002	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Not reported by source	4653ahtpdb / linked
CTPDB_P004795_ACT_ahtpdb_0015	Metabolic/Cardiovascular	ACE Inhibitor	2000.0 µM	Unknown	Not reported by source	6584ahtpdb / linked
CTPDB_P004795_ACT_plantpepdb_0016	Unknown	Taste	Not available in the current structured import	Unknown	Not reported by source	PPepDB_2907plantpepdb / linked
CTPDB_P004795_ACT_plantpepdb_0017	Metabolic/Cardiovascular	Antihypertensive	Not available for this observation	Unknown	Not reported by source	PPepDB_2907plantpepdb / linked
CTPDB_P004795_ACT_satpdb_0018	Metabolic/Cardiovascular	Antihypertensive	Not available for this observation	Unknown	Not reported by source	satpdb27196satpdb / linked

Sequence-linked cross-layer evidence

Linked primary-literature evidence

Records

Papers

Positive

Negative

Primary identities

These observations were collected directly from primary literature and linked by identical normalized sequence. They remain a separate evidence layer and do not overwrite Integrated source-database annotations.

View PEPDIA-PLP-003549 View all experimental records

Provenance

Source database records (18)

ahtpdb

4422

Raw sequence

ahtpdb

4508

Raw sequence

ahtpdb

4653

Raw sequence

ahtpdb

1424

Raw sequence

ahtpdb

1685

Raw sequence

ahtpdb

6584

Raw sequence

ahtpdb

3013

Raw sequence

ahtpdb

3035

Raw sequence

ahtpdb

3057

Raw sequence

ahtpdb

3088

Raw sequence

ahtpdb

3093

Raw sequence

ahtpdb

3128

Raw sequence

ahtpdb

3233

Raw sequence

ahtpdb

3482

Raw sequence

ahtpdb

3802

Raw sequence

ahtpdb

3914

Raw sequence

plantpepdb

PPepDB_2907

Raw sequence

satpdb

satpdb27196

Raw sequence

Citation trail

Literature (11 records)

Modelling relationship between angiotensin-(I)-converting enzyme inhibition and the bitter taste of peptides

Are Hugo Pripp, Ylva Ardö

Food Chemistry - FOOD CHEM 01/2007; 102(3):880-888.2007

QSAR study on angiotensin-converting enzyme inhibitor oligopeptides based on a novel set of sequence information descriptors.

Wang X1, Wang J, Lin Y, Ding Y, Wang Y, Cheng X, Lin Z.

J Mol Model. 2011 Jul;17(7):1599-606.2011PMID 20941517

What are the ideal properties for functional food peptides with antihypertensive effect? A computational peptidology approach.

Zhou P et al.

Food Chem. 2013 Dec 1;141(3):2967-73.2013PMID 23871047

Structural requirements of Angiotensin I-converting enzyme inhibitory peptides: quantitative structure-activity relationship study of di- and tripeptides.

Wu J1, Aluko RE, Nakai S.

J Agric Food Chem. 2006 Feb 8;54(3):732-8.2006PMID 16448176

BIOPEP-PBIL Tool for the Analysis of the Structure of Biologically Active Motifs Derived from Food Proteins

Anna Iwaniak* and Jerzy Dziuba

Analysis of Biologically Active Motifs, Food Technol. Biotechnol. 49 (1) 118–127 (2011)2011

Binding of peptide substrates and inhibitors of angiotensin-converting enzyme. Importance of the COOH-terminal dipeptide sequence.

Cheung HS et al.,

J Biol Chem. 1980 Jan 25;255(2):401-7.1980PMID 6243277

Peptides with angiotensin I converting enzyme (ACE) inhibitory activity generated from porcine skeletal muscle proteins by the action of meat-borne Lactobacillus.

Castellano P1, Aristoy MC, Sentandreu MÁ, Vignolo G, Toldrá F.

J Proteomics. 2013 Aug 26;89:183-90.2013PMID 23806758

Animal and Plant Proteins as Precursors of Peptides with ACE Inhibitory Activity – An in silico Strategy of Protein Evaluation

Anna Iwaniak and Jerzy Dziuba

Food Technol. Biotechnol. 47 (4) 441–449 (2009)2009

MOTIFS WITH POTENTIAL PHYSIOLOGICAL ACTIVITY IN FOOD PROTEINS - BIOPEP DATABASE

Iwaniak, Anna; Dziuba, Bartlomiej

Acta Scientiarum Polonorum. Technologia Alimentaria;2009, Vol. 8 Issue 3, p592009

Three-dimensional holograph vector of atomic interaction field (3D-HoVAIF): a novel rotation-translation invariant 3D structure descriptor and its applications to peptides.

Tian F1, Zhou P, Lv F, Song R, Li Z.

J Pept Sci. 2007 Aug;13(8):549-66.2007PMID 17654623

Identification of Bioactive Peptides from Cereal Storage Proteins and Their Potential Role in Prevention of Chronic Diseases

Ariel Cavazos and Elvira Gonzalez de Mejia

Comprehensive Reviews in Food Science and Food Safety Volume 12, Issue 4, pages 364–380, July 20132013

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:10.991164+00:00

Modification summary

No structured modification annotations are available for this record.

Source metadata

[
  {
    "source_db": "ahtpdb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "plantpepdb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "satpdb",
    "organism_name": "Unknown"
  }
]

Structure metadata

{
  "source_db": "satpdb",
  "dssp_states": "CC"
}