PepDiana
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Primary experimental recordPositive observation

PMC13231543::ACT047749

sP10

Evidence text

Paper-level observation

if the cells were treated with the combination of CHX and MG132 or CHX and CQ, both could prevent the decrease in NPM1 protein level, and especially CQ significantly upregulated the level of NPM1 protein (Fig. 5D).
figureConfidence: medium

Assay observation

Activity
Anticancer
Subtype
Not reported by source
Measure
qualitative
Comparator
=
Raw observation
degradation prevented by CQ, not by MG132
Normalized measurement
=32
Value minimum
Not reported by source
Value maximum
Not reported by source
Target
SK-Hep1
Assay method
Not reported by source
Sequence
YGRKKRRQRRRCGPVWFLIFSYFLFFSISLARGPC
Standardization
ready simple

Source publication

Peptide aptamer sP10 targeting NPM1 attenuates liver fibrosis and hepatocellular carcinoma.

Journal of Translational Medicine · 2026

DOI 10.1186/s12967-026-08144-8 PMC13231543
Parent mention

Related peptide identities

PEPDIA-PLP-003251

Release PepDiana-V1-20260620. The stable record URL can be cited directly in supplementary material and downstream analyses.