PepDiana
Back to Evidence
Primary experimental recordNegative / threshold

PMC13231543::ACT047745

sP10

Evidence text

Paper-level observation

sP10 significantly reduced cytoplasmic translocation of NPM1 in HCC cell lines (SK-Hep1, Hepa1-6, LM3) but not in normal hepatocytes AML12 (Fig. 4E).
figureConfidence: medium

Assay observation

Activity
Toxicity
Subtype
Cytotoxic
Measure
qualitative
Comparator
range
Raw observation
no significant effect
Normalized measurement
Not reported by source
Value minimum
Not reported by source
Value maximum
Not reported by source
Target
AML-12
Assay method
Not reported by source
Sequence
YGRKKRRQRRRCGPVWFLIFSYFLFFSISLARGPC
Standardization
ready simple

Source publication

Peptide aptamer sP10 targeting NPM1 attenuates liver fibrosis and hepatocellular carcinoma.

Journal of Translational Medicine · 2026

DOI 10.1186/s12967-026-08144-8 PMC13231543
Parent mention

Related peptide identities

PEPDIA-PLP-003251

Release PepDiana-V1-20260620. The stable record URL can be cited directly in supplementary material and downstream analyses.