PepDiana
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Primary experimental recordPositive observation

PMC13231543::ACT047744

sP10

Evidence text

Paper-level observation

sP10 significantly reduced cytoplasmic translocation of NPM1 in HCC cell lines (SK-Hep1, Hepa1-6, LM3) but not in normal hepatocytes AML12 (Fig. 4E).
figureConfidence: medium

Assay observation

Activity
Anticancer
Subtype
Not reported by source
Measure
qualitative
Comparator
range
Raw observation
significantly reduced cytoplasmic translocation of NPM1
Normalized measurement
1–6
Value minimum
1
Value maximum
6
Target
Hepa1-6
Assay method
Not reported by source
Sequence
YGRKKRRQRRRCGPVWFLIFSYFLFFSISLARGPC
Standardization
ready simple

Source publication

Peptide aptamer sP10 targeting NPM1 attenuates liver fibrosis and hepatocellular carcinoma.

Journal of Translational Medicine · 2026

DOI 10.1186/s12967-026-08144-8 PMC13231543
Parent mention

Related peptide identities

PEPDIA-PLP-003251

Release PepDiana-V1-20260620. The stable record URL can be cited directly in supplementary material and downstream analyses.