PepDiana
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Primary experimental recordPositive observation

PMC13231543::ACT047739

sP10

Evidence text

Paper-level observation

Quantitative PCR demonstrated marked suppression of M2 markers (CD206, Arg-1, IL-10) (Fig. 6B).
figureConfidence: medium

Assay observation

Activity
Immunomodulatory
Subtype
Anti-inflammatory
Measure
qualitative
Comparator
=
Raw observation
inhibited the expression of M2 polarization markers CD206, Arg-1 and IL-10
Normalized measurement
=6
Value minimum
Not reported by source
Value maximum
Not reported by source
Target
THP-1-derived macrophages
Assay method
Not reported by source
Sequence
YGRKKRRQRRRCGPVWFLIFSYFLFFSISLARGPC
Standardization
ready simple

Source publication

Peptide aptamer sP10 targeting NPM1 attenuates liver fibrosis and hepatocellular carcinoma.

Journal of Translational Medicine · 2026

DOI 10.1186/s12967-026-08144-8 PMC13231543
Parent mention

Related peptide identities

PEPDIA-PLP-003251

Release PepDiana-V1-20260620. The stable record URL can be cited directly in supplementary material and downstream analyses.