PepDiana
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Primary experimental recordPositive observation

PMC13231543::ACT047718

sP10

Evidence text

Paper-level observation

The binding of sP10 and NPM1 was analyzed using Surface Plasmon Resonance (SPR) technology, which demonstrated that NPM had a strong affinity for sP10, and the equilibrium dissociation constant KD was found to be 9.216E-9 (Fig. 1G).
textConfidence: medium

Assay observation

Activity
Anticancer
Subtype
ACE Inhibitor
Measure
Kd
Comparator
=
Raw observation
9.216E-9 M
Normalized measurement
=0.000000009216 other
Value minimum
Not reported by source
Value maximum
Not reported by source
Target
NPM1
Assay method
Not reported by source
Sequence
YGRKKRRQRRRCGPVWFLIFSYFLFFSISLARGPC
Standardization
ready simple
Assay conditions
"original_unit=M"

Source publication

Peptide aptamer sP10 targeting NPM1 attenuates liver fibrosis and hepatocellular carcinoma.

Journal of Translational Medicine · 2026

DOI 10.1186/s12967-026-08144-8 PMC13231543
Parent mention

Related peptide identities

PEPDIA-PLP-003251

Release PepDiana-V1-20260620. The stable record URL can be cited directly in supplementary material and downstream analyses.