PepDiana
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Primary experimental recordPositive observation

PMC13117951::ACT043845

GRVPR

Evidence text

Paper-level observation

treatment with 200 µM tuna peptides S1, S5, S6, and S7 significantly reduced p65 mRNA expression and increased IκBα mRNA expression (p < 0.001). (Figure 11A,B)
textConfidence: medium

Assay observation

Activity
Immunomodulatory
Subtype
Anti-inflammatory
Measure
other
Comparator
=
Raw observation
significantly reduced p65 mRNA, increased IκBα mRNA
Normalized measurement
=5
Value minimum
Not reported by source
Value maximum
Not reported by source
Target
Mus musculus
Assay method
Not reported by source
Sequence
GRVPR
Standardization
ready simple

Source publication

Antioxidant Peptides from Skipjack tuna: Ameliorate Function on Cigarette Smoke Extract-Induced COPD in Cell Model by Targeting Oxidative Stress, Inflammation and Apoptosis

Marine Drugs · 2026

DOI 10.3390/md24040140 PMC13117951
Parent mention

Related peptide identities

PEPDIA-PLP-001112

Release PepDiana-V1-20260620. The stable record URL can be cited directly in supplementary material and downstream analyses.