PepDiana
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Primary experimental recordPositive observation

PMC12858582::ACT035384

TpNPY

Evidence text

Paper-level observation

Fig. 7E-H: the application of TpNPY dramatically prevented glutamate-induced calcium overload and ROS accumulation.
textConfidence: medium

Assay observation

Activity
Other
Subtype
Antibacterial
Measure
percent_inhibition
Comparator
=
Raw observation
prevented glutamate-induced calcium overload and ROS accumulation
Normalized measurement
Not reported by source
Value minimum
Not reported by source
Value maximum
Not reported by source
Target
Mus musculus
Assay method
Not reported by source
Sequence
VGGPPKRPESFKSMAELNAYLSDLAGYYTVIGRPRF
Standardization
ready simple

Source publication

A coral-derived neuropeptide suppresses pentylenetetrazol (PTZ)-induced epileptic seizures and improves recognition memory deficits by modulating NPY-Y1R

Archives of Toxicology · 2026

DOI 10.1007/s00204-025-04164-3 PMC12858582
Parent mention

Related peptide identities

PEPDIA-PLP-002974

Release PepDiana-V1-20260620. The stable record URL can be cited directly in supplementary material and downstream analyses.