PepDiana
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Primary experimental recordPositive observation

PMC12858582::ACT035382

TpNPY

Evidence text

Paper-level observation

Fig. 6F-H: glutamate stimulation significantly decreased the expression of Bcl-2 and increased the expression of Bax in HT22 cells, while treatment with TpNPY abolished these effects.
textConfidence: medium

Assay observation

Activity
Other
Subtype
Antibacterial
Measure
fold_change
Comparator
=
Raw observation
decreased Bax and increased Bcl-2 expression
Normalized measurement
=2
Value minimum
Not reported by source
Value maximum
Not reported by source
Target
Mus musculus
Assay method
Not reported by source
Sequence
VGGPPKRPESFKSMAELNAYLSDLAGYYTVIGRPRF
Standardization
ready simple

Source publication

A coral-derived neuropeptide suppresses pentylenetetrazol (PTZ)-induced epileptic seizures and improves recognition memory deficits by modulating NPY-Y1R

Archives of Toxicology · 2026

DOI 10.1007/s00204-025-04164-3 PMC12858582
Parent mention

Related peptide identities

PEPDIA-PLP-002974

Release PepDiana-V1-20260620. The stable record URL can be cited directly in supplementary material and downstream analyses.