PepDiana
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Primary experimental recordPositive observation

PMC12858582::ACT035378

TpNPY

Evidence text

Paper-level observation

Fig. 5B-D: PTZ treatment significantly decreased the expression levels of TrkB and BDNF, while the administration of TpNPY dose-dependently upregulates these two proteins.
textConfidence: medium

Assay observation

Activity
Other
Subtype
Antibacterial
Measure
fold_change
Comparator
=
Raw observation
dose-dependently upregulated TrkB and BDNF
Normalized measurement
Not reported by source
Value minimum
Not reported by source
Value maximum
Not reported by source
Target
Mus musculus
Assay method
Not reported by source
Sequence
VGGPPKRPESFKSMAELNAYLSDLAGYYTVIGRPRF
Standardization
ready simple

Source publication

A coral-derived neuropeptide suppresses pentylenetetrazol (PTZ)-induced epileptic seizures and improves recognition memory deficits by modulating NPY-Y1R

Archives of Toxicology · 2026

DOI 10.1007/s00204-025-04164-3 PMC12858582
Parent mention

Related peptide identities

PEPDIA-PLP-002974

Release PepDiana-V1-20260620. The stable record URL can be cited directly in supplementary material and downstream analyses.