PepDiana
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Primary experimental recordPositive observation

PMC12858582::ACT035372

TpNPY

Evidence text

Paper-level observation

Fig. 3D-F: PTZ administration significantly upregulated the expression levels of IL-6, IL-1β, and TNF-α in the mouse hippocampus... In contrast, TpNPY treatment effectively reversed these PTZ-induced elevations in proinflammatory cytokine expression.
textConfidence: medium

Assay observation

Activity
Immunomodulatory
Subtype
Anti-inflammatory
Measure
percent_inhibition
Comparator
=
Raw observation
effectively reversed PTZ-induced elevations in IL-6, IL-1β, and TNF-α
Normalized measurement
=6
Value minimum
Not reported by source
Value maximum
Not reported by source
Target
Mus musculus
Assay method
Not reported by source
Sequence
VGGPPKRPESFKSMAELNAYLSDLAGYYTVIGRPRF
Standardization
ready simple

Source publication

A coral-derived neuropeptide suppresses pentylenetetrazol (PTZ)-induced epileptic seizures and improves recognition memory deficits by modulating NPY-Y1R

Archives of Toxicology · 2026

DOI 10.1007/s00204-025-04164-3 PMC12858582
Parent mention

Related peptide identities

PEPDIA-PLP-002974

Release PepDiana-V1-20260620. The stable record URL can be cited directly in supplementary material and downstream analyses.