PepDiana
Back to Evidence
Primary experimental recordPositive observation

PMC12858582::ACT035371

TpNPY

Evidence text

Paper-level observation

Fig. 3B and C: TpNPY dose-dependently augmented the latency to seizure generation, as well as decreased the duration of generalized seizures.
textConfidence: medium

Assay observation

Activity
Other
Subtype
Anti-inflammatory
Measure
qualitative
Comparator
=
Raw observation
dose-dependently augmented the latency to seizure generation and decreased the duration of generalized seizures
Normalized measurement
Not reported by source
Value minimum
Not reported by source
Value maximum
Not reported by source
Target
Mus musculus
Assay method
Not reported by source
Sequence
VGGPPKRPESFKSMAELNAYLSDLAGYYTVIGRPRF
Standardization
ready simple

Source publication

A coral-derived neuropeptide suppresses pentylenetetrazol (PTZ)-induced epileptic seizures and improves recognition memory deficits by modulating NPY-Y1R

Archives of Toxicology · 2026

DOI 10.1007/s00204-025-04164-3 PMC12858582
Parent mention

Related peptide identities

PEPDIA-PLP-002974

Release PepDiana-V1-20260620. The stable record URL can be cited directly in supplementary material and downstream analyses.