Primary experimental recordPositive observation

PMC12858582::ACT035370

TpNPY

Evidence text

Paper-level observation

Fig. 3A: after 15 injections, the seizure score in PTZ-treated group arrived at 4.91±0.41; whereas TpNPY treatment at 0.25, 0.5, and 1 mg/kg reduced the seizure score to 4.69±0.32, 3.60±0.47, and 2.62±0.35, respectively.

textConfidence: medium

Assay observation

Activity

Other

Subtype

Anti-inflammatory

Measure

qualitative

Comparator

Raw observation

reduced seizure score from 4.91±0.41 (PTZ) to 2.62±0.35 (1 mg/kg TpNPY)

Normalized measurement

~4.91

Value minimum

Not reported by source

Value maximum

Not reported by source

Target

Mus musculus

Assay method

Not reported by source

Sequence

VGGPPKRPESFKSMAELNAYLSDLAGYYTVIGRPRF

Standardization

ready simple

Source publication

A coral-derived neuropeptide suppresses pentylenetetrazol (PTZ)-induced epileptic seizures and improves recognition memory deficits by modulating NPY-Y1R

Archives of Toxicology · 2026

DOI 10.1007/s00204-025-04164-3 PMC12858582

Parent mention

Related peptide identities

PEPDIA-PLP-002974

Release PepDiana-V1-20260620. The stable record URL can be cited directly in supplementary material and downstream analyses.