Primary experimental recordPositive observation

PMC12858582::ACT035369

TpNPY

Evidence text

Paper-level observation

Fig. 2C and F: the ROS levels in zebrafish larvae upregulated dramatically following PTZ challenge. Nevertheless, treatment with TpNPY mitigated the overaccumulation of ROS elicited by PTZ effectively.

textConfidence: medium

Assay observation

Activity

Antioxidant

Subtype

Antibacterial

Measure

percent_inhibition

Comparator

Raw observation

mitigated the overaccumulation of ROS

Normalized measurement

Not reported by source

Value minimum

Not reported by source

Value maximum

Not reported by source

Target

Danio rerio

Assay method

Not reported by source

Sequence

VGGPPKRPESFKSMAELNAYLSDLAGYYTVIGRPRF

Standardization

ready simple

Source publication

A coral-derived neuropeptide suppresses pentylenetetrazol (PTZ)-induced epileptic seizures and improves recognition memory deficits by modulating NPY-Y1R

Archives of Toxicology · 2026

DOI 10.1007/s00204-025-04164-3 PMC12858582

Parent mention

Related peptide identities

PEPDIA-PLP-002974

Release PepDiana-V1-20260620. The stable record URL can be cited directly in supplementary material and downstream analyses.