PepDiana
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Primary experimental recordPositive observation

PMC12858582::ACT035368

TpNPY

Evidence text

Paper-level observation

Fig. 2D and E: the mRNA expression levels of these two genes were significantly upregulated in response to PTZ treatment. However, treatment with TpNPY successfully reversed this overexpression.
textConfidence: medium

Assay observation

Activity
Other
Subtype
Anti-inflammatory
Measure
fold_change
Comparator
=
Raw observation
reversed overexpression of c-fos and npas4a
Normalized measurement
Not reported by source
Value minimum
Not reported by source
Value maximum
Not reported by source
Target
Danio rerio
Assay method
Not reported by source
Sequence
VGGPPKRPESFKSMAELNAYLSDLAGYYTVIGRPRF
Standardization
ready simple

Source publication

A coral-derived neuropeptide suppresses pentylenetetrazol (PTZ)-induced epileptic seizures and improves recognition memory deficits by modulating NPY-Y1R

Archives of Toxicology · 2026

DOI 10.1007/s00204-025-04164-3 PMC12858582
Parent mention

Related peptide identities

PEPDIA-PLP-002974

Release PepDiana-V1-20260620. The stable record URL can be cited directly in supplementary material and downstream analyses.