PepDiana
Back to Evidence
Primary experimental recordPositive observation

PMC12858582::ACT035367

TpNPY

Evidence text

Paper-level observation

Fig. 2B: the application of 10 mM PTZ dramatically altered the swimming pattern of the zebrafish, as reflected by the increased distance traveled at high speed, whereas these abnormal seizure-like behavior phenotypes were abolished under the treatment of TpNPY (0.75–6 μM).
textConfidence: medium

Assay observation

Activity
Other
Subtype
Anti-inflammatory
Measure
percent_inhibition
Comparator
range
Raw observation
abolished abnormal seizure-like behavior phenotypes
Normalized measurement
0.75–6
Value minimum
0.75
Value maximum
6
Target
Danio rerio
Assay method
Not reported by source
Sequence
VGGPPKRPESFKSMAELNAYLSDLAGYYTVIGRPRF
Standardization
ready simple

Source publication

A coral-derived neuropeptide suppresses pentylenetetrazol (PTZ)-induced epileptic seizures and improves recognition memory deficits by modulating NPY-Y1R

Archives of Toxicology · 2026

DOI 10.1007/s00204-025-04164-3 PMC12858582
Parent mention

Related peptide identities

PEPDIA-PLP-002974

Release PepDiana-V1-20260620. The stable record URL can be cited directly in supplementary material and downstream analyses.