PepDiana
Back to Evidence
Primary experimental recordPositive observation

PMC12858582::ACT035366

TpNPY

Evidence text

Paper-level observation

Fig. 2A: TpNPY at concentrations of 6–25 μM did not lead to any substantial changes in the survival rate of zebrafish larvae. However, once the concentration arrived at 40 μM, the mortality rate of zebrafish larvae sharply increased, reaching approximately 50%.
textConfidence: medium

Assay observation

Activity
Other
Subtype
General Toxic
Measure
survival_rate
Comparator
~
Raw observation
no substantial changes in survival rate at 6–25 μM; ~50% mortality at 40 μM
Normalized measurement
~50 µM
Value minimum
Not reported by source
Value maximum
Not reported by source
Target
Danio rerio
Assay method
Not reported by source
Sequence
VGGPPKRPESFKSMAELNAYLSDLAGYYTVIGRPRF
Standardization
ready simple

Source publication

A coral-derived neuropeptide suppresses pentylenetetrazol (PTZ)-induced epileptic seizures and improves recognition memory deficits by modulating NPY-Y1R

Archives of Toxicology · 2026

DOI 10.1007/s00204-025-04164-3 PMC12858582
Parent mention

Related peptide identities

PEPDIA-PLP-002974

Release PepDiana-V1-20260620. The stable record URL can be cited directly in supplementary material and downstream analyses.