PepDiana
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Primary experimental recordPositive observation

PMC12677653::ACT031890

Insig1/2 loop 1 peptide

Evidence text

Paper-level observation

Insig1/2 loop 1 peptide exhibited much stronger binding affinity for the S90-phosphorylated GST-PCK1 protein than nonphosphorylated GST-PCK1 (Figure 1b,c)
textConfidence: medium

Assay observation

Activity
Metabolic/Cardiovascular
Subtype
ACE Inhibitor
Measure
Kd
Comparator
=
Raw observation
much stronger binding affinity
Normalized measurement
=2
Value minimum
Not reported by source
Value maximum
Not reported by source
Target
GST-PCK1 pS90
Assay method
Not reported by source
Sequence
LYPCIDSHLGEPHKFKRE
Standardization
ready simple

Source publication

Inhibition of Tumor Lipogenesis and Growth by Peptide‐Based Targeting of SREBP Activation

Advanced Science · 2025

DOI 10.1002/advs.202508111 PMC12677653
Parent mention

Related peptide identities

PEPDIA-PLP-001956

Release PepDiana-V1-20260620. The stable record URL can be cited directly in supplementary material and downstream analyses.