PepDiana
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Primary experimental recordPositive observation

PMC12677653::ACT031854

Insig1/2 loop 1 peptide

Evidence text

Paper-level observation

The Insig1/2 loop 1 peptide markedly inhibited IGF1-induced binding of PCK1 to Insig1 (Figure 1d)
textConfidence: medium

Assay observation

Activity
Metabolic/Cardiovascular
Subtype
Antibacterial
Measure
percent_inhibition
Comparator
=
Raw observation
markedly inhibited
Normalized measurement
=2
Value minimum
Not reported by source
Value maximum
Not reported by source
Target
Homo sapiens
Assay method
Not reported by source
Sequence
LYPCIDSHLGEPHKFKRE
Standardization
ready simple

Source publication

Inhibition of Tumor Lipogenesis and Growth by Peptide‐Based Targeting of SREBP Activation

Advanced Science · 2025

DOI 10.1002/advs.202508111 PMC12677653
Parent mention

Related peptide identities

PEPDIA-PLP-001956

Release PepDiana-V1-20260620. The stable record URL can be cited directly in supplementary material and downstream analyses.