PepDiana
Back to Evidence
Primary experimental recordPositive observation

PMC10668963::ACT002849

G54-LNA

Evidence text

Paper-level observation

Section 3.3: 'The IC50 values were equal to 50 ± 30 nM (G54-LNA)' in HEK-293T-ACE2 cells.
textConfidence: medium

Assay observation

Activity
Antiviral
Subtype
General Antiviral
Measure
other
Comparator
=
Raw observation
50 ± 30 nM
Normalized measurement
=50 nM
Value minimum
20 nM
Value maximum
80 nM
Target
HEK-293T-ACE2
Assay method
Not reported by source
Sequence
Not reported by source
Standardization
insufficient information

Source publication

Unwinding the SARS-CoV-2 Ribosomal Frameshifting Pseudoknot with LNA and G-Clamp-Modified Phosphorothioate Oligonucleotides Inhibits Viral Replication

Biomolecules · 2023

DOI 10.3390/biom13111660 PMC10668963
Parent mention

Release PepDiana-V1-20260620. The stable record URL can be cited directly in supplementary material and downstream analyses.