Aptamer-target interaction descriptor
Aptamer-target interaction information
Interaction ID: 689
Aptamer sequence: TGGAGCTTGGATTGATGTGGTGTGTGAGTGCGGTGCCC
Target unique ID: 151243
| Aptamer ID | Aptamer descriptor | Target chemistry | Target name | Affinity | Binding Conditions/Buffer | PubMed ID |
|---|---|---|---|---|---|---|
| Apta_646 | pe35 | Molecule | L-Tyrosinamide | 45 μM | 20 mM Tris (pH 7.6), 300 mM NaCl, 5 mM MgCl2 | 11557341 |
Structure information of aptamer
| Aptamer Sequence: | TGGAGCTTGGATTGATGTGGTGTGTGAGTGCGGTGCCC |
| The optimal secondary structure in dot-bracket notation: | .((.(((((.(((.((.......)).))).))).)))) |
| The centroid secondary structure in dot-bracket notation: | .((.(((((.(((.((.......)).))).))).)))) |
The MFE structure
The Centroid structure
The mountain plot representation
Aptamer information
| Type | Detail | Type | Detail |
|---|---|---|---|
| Aptamer ID | Apta_646 | Description | pe35 |
| Aptamer chemistry | DNA | Length | 38 nt |
| GC content | 57.9% | Molecular weight | 11,883.59 Da |
| Molarity of 1 μg/μl solution | 84.15 μM | Number of G-quadruplexes | No QGRS found |
| G-Score | N/A | Function | Targeted binding |
| Sequence | TGGAGCTTGGATTGATGTGGTGTGTGAGTGCGGTGCCC | ||
| Applications | Binding to L-tryptophan | ||
Target information
| Type | Detail | Type | Detail |
|---|---|---|---|
| PubChem ID | 151243 | Molecular name | L-Tyrosinamide |
| Molecular formula | C9H12N2O2 | Molecular weight | 180.2 |
| IUPAC name | (2S)-2-amino-3-(4-hydroxyphenyl)propanamide | InChIKey | PQFMNVGMJJMLAE-QMMMGPOBSA-N |
| LogP | -0.253 | Topological polar surface area | 89.34 |
| Hydrogen bond acceptor | 3 | Hydrogen bond donor | 3 |
Synonym(s): L-Tyrosine amide; 4985-46-0; L-Tyrosinamide; H-TYR-NH2; Tyrosinamide; Tyrosine amide; (2S)-2-amino-3-(4-hydroxyphenyl)propanamide; (S)-2-Amino-3-(4-hydroxyphenyl)propanamide; UNII-05LU01CS4T; 05LU01CS4T; tyrosine imine; L-Tyr-NH2; TYC; SCHEMBL358908; CHEBI:21412; DTXSID70198120; STR05440; ZINC4899513; MFCD00069935; AKOS005067895; AM82347; CS-W008559; DB03380; AC-13399; BP-12563; D83107; 985T460; A871706; Benzenepropanamide, alpha-amino-4-hydroxy-, (S)-; Q27094319; Benzenepropanamide, .alpha.-amino-4-hydroxy-, (.alpha.S)
Activity data
|
No relevant experimental diagram |
Interaction ID | 689 |
| Target type | Molecule | |
| Target unique ID | 151243 | |
| Activity | 45 μM | |
| Binding Conditions/Buffer | 20 mM Tris (pH 7.6), 300 mM NaCl, 5 mM MgCl2 |
|
| Assay | N/A |
|
| PubMed ID | 11557341 |
Similar aptamers
| Aptamer ID | Aptamer chemistry | Sequence | Similarity |
|---|---|---|---|
| Apta_73 | DNA | GGGGAGTAGGTTGGTGTGGTTGGGGCTCCCC | |
| Apta_71 | DNA | GGCGAGTAGGTTGGTGTGGTTGGGGCTCGCC | |
| Apta_74 | DNA | GGACAGTAGGTTGGTGTGGTTGGGGCTGTCC | |
| Apta_1247 | DNA | GGTGGTTGCTGTTGTTTGTGGTTGGTGTGC | |
| Apta_69 | DNA | AGCGAGTAGGTTGGTGTGGTTGGGGCTCGCT | |
| Apta_70 | DNA | AGGTCGTAGGTTGGTGTGGTTGGGGCGACCT | |
| Apta_72 | DNA | AGTCAGTAGGTTGGTGTGGTTGGGGCTGACT | |
| Apta_146 | DNA | GGTGCGGTTCGTGCGGTTGTAGTACTCGTGGCCG | |
| Apta_1085 | DNA | TGGGGTGGTGGTGTGGGTGGGGGTTTGTTC | |
| Apta_1241 | DNA | GGTGTGGAGTGGTGTGTGTTGTTGTTTGTC | |
| Apta_1246 | DNA | GGAGATGTATGAGCGGGTGTTTGTGTTTGC | |
| Apta_58 | DNA | GCACCTTGATGACATGATAGTCGTTGTGTATGCAGTTGGC | |
| Apta_1188 | DNA | CGGGCGGGGCGTGGGGTGTTGGAGTGGAGGGCGGGGCGGC | |
| Apta_1258 | DNA | GGCGAAGGAGTCATGTAGGTGTGGTCGAGACCGCTGTGCT | |
| Apta_733 | DNA | TAGGCAGTGGTTTGACGTCCGCATGTTGGGAATAGCCACGCCT | |
| Apta_17 | DNA | AGGGGGGGGGGTGGGGGTGGGTCCC | |
| Apta_350 | DNA | GGTGGTGGTGGTTGTGGTGGTGGTGG | |
| Apta_364 | DNA | TATGGTATGCTGTGTGGTATGGGGTGGCGTGCTCT | |
| Apta_543 | DNA | GGCACGTGTTGTCTCTCTGTGTCTCGTGCC | |
| Apta_757 | DNA | GGTGGTGGTGGTTGTGGTGGTGG |
DEV TOOL
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