Aptamer-target interaction descriptor
Aptamer-target interaction information
Interaction ID: 598
Aptamer sequence: GCGGGGTTGGGCGGGTGGGTTCGCTGGGCAGGGGGCGAGTG
Target unique ID: 294
Aptamer ID Aptamer descriptor Target chemistry Target name Affinity Binding Conditions/Buffer PubMed ID
Apta_565 #16 Molecule Cellobiose 600 nM 20 mM Tris (pH 7.5), 100 mM NaCl, 5 mM MgCl2 9576904
Structure information of aptamer
Aptamer Sequence: GCGGGGTTGGGCGGGTGGGTTCGCTGGGCAGGGGGCGAGTG
The optimal secondary structure in dot-bracket notation: ((...(((.(((((......))))).))).....)).....
The centroid secondary structure in dot-bracket notation: ((...(((.(((((......))))).))).....)).....
The MFE structure
The Centroid structure
The mountain plot representation
Aptamer information
Type Detail Type Detail
Aptamer ID Apta_565 Description #16
Aptamer chemistry DNA Length 41 nt
GC content 78.0% Molecular weight 12,988.25 Da
Molarity of 1 μg/μl solution 76.99 μM Number of G-quadruplexes 3
G-Score 63 Function Aptasensor
Sequence GCGGGGTTGGGCGGGTGGGTTCGCTGGGCAGGGGGCGAGTG
Applications Recognition of cellobiose
Target information
Type Detail Type Detail
PubChem ID 294 Molecular name Cellobiose
Molecular formula C12H22O11 Molecular weight 342.3
IUPAC name 2-(hydroxymethyl)-6-[4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxane-3,4,5-triol InChIKey GUBGYTABKSRVRQ-UHFFFAOYSA-N
LogP -5.397 Topological polar surface area 189.53
Hydrogen bond acceptor 11 Hydrogen bond donor 8

Synonym(s):
cellobiose; maltose; D-(+)-Cellobiose; Lactose, alpha-; Lactose, .beta.-; 69-79-4; D-Glucose, 4-O-.beta.-D-glucopyranosyl-; NSC2559; .beta.-D-Glucopyranose, 4-O-.beta.-D-galactopyranosyl-; 528-50-7; 14641-93-1; 4-O-beta-D-Galactopyranosyl-alpha-D-glucopyranose; alpha-D-Lactose; alpha-Lactose; Cellobiose, .beta.-; 80446-85-1; Lactopress; ss-Lactose; Lactose NF; .beta.-Cellobiose; 13360-52-6; 9004-34-6; .beta.-D-Lactose; 4-o-(a-d-galactopyranosyl)-d-glucopyranose; D-Glucose, 4-O-.beta.-D-galactopyranosyl-; cellulose microcrystalline; .beta.-Maltose monohydrate; SCHEMBL684118; .beta.-D-Glucopyranose, 4-O-.beta.-D-glucopyranosyl-; SCHEMBL20276017; SCHEMBL21511124; 56907-30-3; NSC-2559; AKOS015896855; MCULE-2333127533; FT-0619322; FT-0619323; FT-0622905; FT-0624351; FT-0624878; FT-0625411; FT-0625540; FT-0625541; FT-0670942; FT-0689214; FT-0697032; 4-O-.beta.-D-Galactopyranosyl-.beta.-D-glucopyranose; D-Glucose, 4-O-.alpha.-D-glucopyranosyl-, monohydrate; .alpha.-D-Glucopyranose, 4-O-.beta.-D-galactopyranosyl-; 4E82838F-6188-429E-B7BF-E9E27F9F648E

Activity data
Interaction ID 598
Target type Molecule
Target unique ID 294
Activity 600 nM
Binding Conditions/Buffer

20 mM Tris (pH 7.5), 100 mM NaCl, 5 mM MgCl2
Assay

Specificity of aptamer binding
PubMed ID 9576904
Similar aptamers
Aptamer ID Aptamer chemistry Sequence Similarity
Apta_150 DNA CCGTAGGTTCGGGGCGGAGTGGTCCGGAAGGTGGCGTGG 63.41%
Apta_1014 DNA TGGGGGTTGGGTGGATAGGCTGGCGTCGGGGCAGGTCAGT 63.41%
Apta_1189 DNA GCGGGCGGGGGGAGGGCGGCCGTGGGCTGCGAGTGGGAGG 63.41%
Apta_746 DNA AGAGTGGGGGGGTGGGTGGATTTGACAGGTGGCATGCTGGAGAGT 62.22%
Apta_148 DNA CCGTAGGTTCGGGGTCGGAGTGGTCCGGAAGGTGGCGTGG 60.98%
Apta_1195 DNA GGGGTTGGGGGGAGGCGGGGAATGGGGG 60.98%
Apta_1186 DNA AGGGGGTTTTGGTGGGGGGGGCTGGGTTGTCTTGGGGGTGGGCT 59.09%
Apta_10 DNA GGGGGGGGTGGCTGGGCGGGGTGGG 58.54%
Apta_46 DNA CGGGTGGGAGTTGTGGGGGGGGGTGGGAGGGTT 58.54%
Apta_149 DNA CCGTAGGTTCGGGGTCGGAGTGGTCCGGAAGATGGCGTGG 58.54%
Apta_1188 DNA CGGGCGGGGCGTGGGGTGTTGGAGTGGAGGGCGGGGCGGC 58.54%
Apta_754 DNA GGGCGGGGAGTAGGGAGAGGGGTTTCCATCGGCGACAGAGGAGTTATGTGTGT 58.49%
Apta_616 DNA GGTGCGGGTAGGGATGAGGGCGGGTCGGGTTGAGTGTGAGCTTAGGGGtGGCGGATCTAC 58.33%
Apta_488 DNA CGACCAGGGTGGGAGGGGGACGGGCTGGCGGCGCGCGGTAATG 58.14%
Apta_940 DNA TGTGCGGGGGAGGGGAGTGGCGCTGTTGGTGCGGGTATAGCGCGTGGTGT 58.00%
Apta_749 DNA GATCGGTGGGTGGGGGGGTTGGAGATCATCCTCAGGGATTACGTC 57.78%
Apta_1185 DNA CAGGGGGTTTTGGTGGGGGGGGCTGGGTTGTCTTGGGGGTGGGCT 57.78%
Apta_143 DNA GGTGCGGTTCGTGCGGTTGTAGTACTCGTGGCCGATAGAGGTAGTTTCG 57.14%
Apta_617 DNA CAATGGGGTCGGGCGGGCCGGGTGTCATGGTGGACGGAGATGGGACGTAGAGGGCGGT 56.90%
Apta_144 DNA GGTGCGGTTCGTGCGGTTGTAGTACTCGTGGCCGATAGAGGTAG 56.82%

ABOUT

AptaDB is an online database we developed to integrate comprehensive information about aptamer.
The detail of this database is described here:

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