AptaDB: Result

Interaction ID: 1042

Aptamer sequence: GGACCGCTAGGTTCGTGGCTGAGATCACGCGATATCAGTA

Target unique ID: P01266

Aptamer ID	Aptamer descriptor	Target chemistry	Target name	Affinity	Binding Conditions/Buffer	PubMed ID
Apta_959	T-1	Protein	THYG_HUMAN	8.67 μM	TGK, Tris-HCl, BBS, and PBS	33303143

Aptamer Sequence:	GGACCGCTAGGTTCGTGGCTGAGATCACGCGATATCAGTA
The optimal secondary structure in dot-bracket notation:	(((((....)))))...(((((.(((....))).))))).
The centroid secondary structure in dot-bracket notation:	(((((....)))))...(((((.(((....))).))))).

The MFE structure

The Centroid structure

The mountain plot representation

Type	Detail	Type	Detail
Aptamer ID	Apta_959	Description	T-1
Aptamer chemistry	DNA	Length	40 nt
GC content	55.0%	Molecular weight	12,376.95 Da
Molarity of 1 μg/μl solution	80.80 μM	Number of G-quadruplexes	No QGRS found
G-Score	N/A	Function	Aptasensor
Sequence	GGACCGCTAGGTTCGTGGCTGAGATCACGCGATATCAGTA
Applications	CE-based detection validated the application feasibility of aptamer for Tg detection

Type	Detail	Type	Detail
Uniprot ID	P01266	Protein name	Thyroglobulin (Tg)
Gene name(s)	TG	Organism	Thyroglobulin (Tg)
Status	reviewed in uniprot database	Length	2768
Mass	304,790	Activity regulation	N/A
Involvement in disease	Thyroid dyshormonogenesis 3 (TDH3)	Catalytic activity	N/A
PDB ID(s)	6SCJ;7B75;
Function	Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3).

No relevant experimental diagram	Interaction ID	1042
	Target type	Protein
	Target unique ID	P01266
	Activity	8.67 μM
	Binding Conditions/Buffer	TGK, Tris-HCl, BBS, and PBS
	Assay	N/A
	PubMed ID	33303143

Aptamer ID	Aptamer chemistry	Sequence	Similarity
Apta_186	DNA	AGGAACGCTTTAGGTCTGAGATCTCGGAAT	60.00%
Apta_735	DNA	AGGCCCCCAGGCTCGGTGGATGCAAACACATGACTATGGGCCCGT	57.78%
Apta_749	DNA	GATCGGTGGGTGGGGGGGTTGGAGATCATCCTCAGGGATTACGTC	57.78%
Apta_74	DNA	GGACAGTAGGTTGGTGTGGTTGGGGCTGTCC	57.50%
Apta_184	DNA	AGGAAGGCTTTAGGTCTGAGATCTCGGAAT	57.50%
Apta_190	DNA	AGGAACCCTTTAGGTCTGAGATCTCGGAAT	57.50%
Apta_193	DNA	AGGAAGGCTTTAGGGTCTGAGATCTCGGAAT	57.50%
Apta_194	DNA	AGGAAGGCTTTAGGGTCTGAGATCTCGGGAAT	57.50%
Apta_195	DNA	AGGAAGGCTTTAGGGGTCTGAGATCTCGGAAT	57.50%
Apta_498	DNA	GAACTCATTGGCTGGAGGCGGCAGTACCGCTTGAGTT	57.50%
Apta_1204	DNA	GGCACGATGTGGCTACATCGATCGCGGTACTGGTG	57.50%
Apta_1204	DNA	GGCACGATGTGGCTACATCGATCGCGGTACTGGTG	57.50%
Apta_1261	DNA	GGGCGGACGCTAGGTGGTGATGCTGTGCTACACGTGTTGT	57.50%
Apta_144	DNA	GGTGCGGTTCGTGCGGTTGTAGTACTCGTGGCCGATAGAGGTAG	56.82%
Apta_846	DNA	GTGCAGACAGCTAGTAGTGGTGACTTTCTGTCCAAATCAAGATAA	55.56%
Apta_70	DNA	AGGTCGTAGGTTGGTGTGGTTGGGGCGACCT	55.00%
Apta_75	DNA	CACTGGTAGGTTGGTGTGGTTGGGGCCAGTG	55.00%
Apta_146	DNA	GGTGCGGTTCGTGCGGTTGTAGTACTCGTGGCCG	55.00%
Apta_158	DNA	CACAGGCTACGGCACGTAGAGCATCACCATGATCCTGTG	55.00%
Apta_189	DNA	AGGAACCCTTTACCTCTGAGATCTCGGAAT	55.00%

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