MetaADEDB 2.0 @ LMMD
Pentobarbital
(WEXRUCMBJFQVBZ-UHFFFAOYSA-N)
Structure
SMILES
CCCC(C1(CC)C(=O)NC(=O)NC1=O)C
Type(s)
Approved; Investigational; Vet_approved
ATC code(s)
N05CA01; N05CB01
Molecular Formula:
C11H18N2O3
Molecular Weight:
226.272
Log P:
1.8426
Hydrogen Bond Acceptor:
5
Hydrogen Bond Donor:
2
TPSA:
75.27
CAS Number(s):
57-33-0; 76-74-4; 30849-50-4
Synonym(s)
1.
Pentobarbital
2.
Mebubarbital
3.
Mebumal
4.
Diabutal
5.
Etaminal
6.
Ethaminal
7.
Nembutal
8.
Pentobarbital Sodium
9.
Pentobarbital, Monosodium Salt
10.
Pentobarbitone
11.
Sagatal
12.
Monosodium Salt Pentobarbital
External Link(s)
MeSHD010424
PubChem Compound4737
BindingDB50055935
ChEBI7983
CHEMBLCHEMBL448
DrugBankDB00312
DrugCentral2095
IUPHAR/BPS Guide to PHARMACOLOGY5480
KEGGcpd:C07422
dr:D00499
Therapeutic Target DatabaseD0F0YZ
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1PneumoniaFAERS: 4US FAERS
2Urinary tract infectionFAERS: 4US FAERS
3Cerebral atrophyFAERS: 3US FAERS
4Drug toxicityFAERS: 3OFFSIDES
US FAERS
5Brain DeathFAERS: 2US FAERS
6Cardiac DeathFAERS: 2OFFSIDES
US FAERS
7Deep Vein ThrombosisFAERS: 2US FAERS
8Acute kidney injuryFAERS: 1US FAERS
9AgitationFAERS: 1
Canada Vigilance: 4		Canada Vigilance
SIDER
US FAERS
10BradycardiaFAERS: 1

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885163
1765616
6127404
6804092
 		CTD
SIDER
US FAERS
11Cardiac ArrestFAERS: 1US FAERS
12Cerebral salt-wasting syndromeFAERS: 1US FAERS
13Drug level above therapeuticFAERS: 1US FAERS
14General physical health deteriorationFAERS: 1US FAERS
15HypotensionFAERS: 1
Canada Vigilance: 1

View details

1201159
1527734
6127404
6498583
6804092
7477798
8102224
9620510
10399635
11140241
14581915
15295244
29038840
 		CTD
SIDER
Canada Vigilance
US FAERS
16Respiratory arrestFAERS: 1US FAERS
17SepsisFAERS: 1US FAERS
18Accidental overdoseCanada Vigilance: 6Canada Vigilance
19Alcohol problemCanada Vigilance: 3Canada Vigilance
20Alpha-2 macroglobulin increasedCanada Vigilance: 1Canada Vigilance
21AlveolitisOFFSIDES
22Amnesia1616457CTD
23Anemia19999907CTD
24AngioedemaSIDER
25Anxiety Disorders

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1673080
11141031
12783153
18313124
 		CTD
26AnxietySIDER
27Arteriovenous fistula thrombosisOFFSIDES
28AtaxiaCanada Vigilance: 1

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623061
988178
2556616
7965752
 		CTD
SIDER
Canada Vigilance
29AthetosisOFFSIDES
30Atrial Fibrillation18980425CTD
31Atrioventricular Block3590213CTD
32Atrioventricular Septal DefectOFFSIDES
33Blood creatine phosphokinase increasedOFFSIDES
34Brain Diseases623061CTD
35Brain Injuries10928976
20699736		CTD
36Completed SuicideCanada Vigilance: 38Canada Vigilance
OFFSIDES
37Consciousness Disorders623061
11744305		CTD
38ConstipationSIDER
39Craniocerebral Trauma3151702CTD
40CyanosisCanada Vigilance: 1Canada Vigilance
41DeliriumCanada Vigilance: 1Canada Vigilance
42Depressed Level of ConsciousnessSIDER
43DermatitisSIDER
44Disorders of Excessive Somnolence6136932CTD
45DizzinessSIDER
46Drug exposure during pregnancyOFFSIDES
47Edema22982570CTD
48Epilepsy7705426CTD
49ErythemaCanada Vigilance: 1Canada Vigilance
50Feeling abnormalSIDER
51Fixed eruptionCanada Vigilance: 1Canada Vigilance
52HeadacheSIDER
53Heart failure

View details

731938
1386131
2468058
2862850
3199595
3831029
4042115
4381563
6195467
7271381
 		CTD
54Hyperalgesia9239313CTD
55HyperkinesiaSIDER
56HypersensitivitySIDER
57Hypotension, Orthostatic1665057CTD
58HypoventilationSIDER
59HypoxiaSIDER
60Injection Site ReactionSIDER
61Intracranial Hypertension2280744
3151702
20699736		CTD
62LaryngospasmOFFSIDES
63Mitral Valve Insufficiency18455290CTD
64Myoclonic EpilepsyOFFSIDES
65Myoclonus12925183CTD
66Narcolepsy21061460CTD
67NauseaSIDER
68Nerve Degeneration9061777CTD
69NervousnessCanada Vigilance: 1Canada Vigilance
SIDER
70Ocular Motility Disorders6028472CTD
71OverdoseCanada Vigilance: 2Canada Vigilance
72PolyuriaOFFSIDES
73Prenatal Exposure Delayed Effects3925485CTD
74Procedural complicationOFFSIDES
75PruritusCanada Vigilance: 1Canada Vigilance
76Pulmonary Valve Insufficiency18455290CTD
77Reflex, Abnormal10930210
12657854		CTD
78Respiratory FailureSIDER
79Respiratory Insufficiency1527734CTD
80Respiratory Paralysis2064036CTD
81ScreamingCanada Vigilance: 1Canada Vigilance
82Seizures

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1665475
2408303
3010161
3724361
7698200
9061777
9754883
10087439
12782101
 		CTD
83ShockSIDER
84SomnolenceCanada Vigilance: 2Canada Vigilance
SIDER
85Spasm4758360
6028472		CTD
86Status Epilepticus

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7737389
8814099
9129572
11587876
17168987
 		CTD
87Stupor

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416961
2845442
2945998
7172122
8690305
 		CTD
88Substance Withdrawal Syndrome

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6683313
7862907
8433409
9754883
11529278
 		CTD
89SyncopeSIDER
90Tachycardia, Ventricular235395
8739209		CTD
91Tachycardia7120521CTD
92TensionSIDER
93Tremor7639639CTD
94Upper airway obstructionOFFSIDES
95UrticariaCanada Vigilance: 3Canada Vigilance
96Ventricular Dysfunction, Left3789173
7995660		CTD
97Ventricular Fibrillation2880726CTD
98Ventricular hypokinesiaOFFSIDES
99VomitingCanada Vigilance: 1623061
15295244		CTD
SIDER
Canada Vigilance
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