Aptamer-target interaction descriptor
Aptamer-target interaction information
| Aptamer ID | Aptamer descriptor | Target chemistry | Target name | Affinity | Binding Conditions/Buffer | PubMed ID |
|---|---|---|---|---|---|---|
| Apta_320 | Vap7 | Protein | VEGFA_HUMAN | 1.0 nM | 10% (v/v) human serum in TBSTE (TBSE containing 0.05% (v/v) of Tween-20) | 20110884 |
Structure information of aptamer
| Aptamer Sequence: | GCACTCTGTGGGGGTGGACGGGCCGGGT |
| The optimal secondary structure in dot-bracket notation: | .((((((...))))))............ |
| The centroid secondary structure in dot-bracket notation: | .((((((...))))))............ |
The MFE structure
The Centroid structure
The mountain plot representation
Aptamer information
| Type | Detail | Type | Detail |
|---|---|---|---|
| Aptamer ID | Apta_320 | Description | Vap7 |
| Aptamer chemistry | DNA | Length | 28 nt |
| GC content | 75.0% | Molecular weight | 8,998.54 Da |
| Molarity of 1 μg/μl solution | 111.13 μM | Number of G-quadruplexes | 2 |
| G-Score | 21 | Function | Targeted binding |
| Sequence | GCACTCTGTGGGGGTGGACGGGCCGGGT | ||
| Applications | Binding to VEGF | ||
Target information
| Type | Detail | Type | Detail |
|---|---|---|---|
| Uniprot ID | P15692 | Protein name | Vascular endothelial growth factor A (VEGF-A) (Vascular permeability factor) (VPF) |
| Gene name(s) | VEGFA VEGF | Organism | Vascular endothelial growth factor A (VEGF-A) (Vascular permeability factor) (VPF) |
| Status | reviewed in uniprot database | Length | 232 |
| Mass | 27,042 | Activity regulation | N/A |
| Involvement in disease | Microvascular complications of diabetes 1 (MVCD1) | Catalytic activity | N/A |
| PDB ID(s) | 1BJ1;1CZ8;1FLT;1KAT;1KMX;1MJV;1MKG;1MKK;1QTY;1TZH;1TZI;1VGH;1VPF;1VPP;2FJG;2FJH;2QR0;2VGH;2VPF;3BDY;3P9W;3QTK;3S1B;3S1K;3V2A;4DEQ;4GLN;4GLS;4KZN;4QAF;4WPB;4ZFF;5DN2;5FV1;5FV2;5HHC;5HHD;5O4E;5T89;6BFT;6D3O;6T9D;6V7K;6Z13;6Z3F;6ZBR;6ZCD;6ZFL;7KEZ;7KF0;7KF1;7LL8;7LL9; |
 |
Function | Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. |
Activity data
|
No relevant experimental diagram |
Interaction ID | 518 |
| Target type | Protein | |
| Target unique ID | P15692 | |
| Activity | 1.0 nM | |
| Binding Conditions/Buffer | 10% (v/v) human serum in TBSTE (TBSE containing 0.05% (v/v) of Tween-20) |
|
| Assay | N/A |
|
| PubMed ID | 20110884 |
Similar aptamers
| Aptamer ID | Aptamer chemistry | Sequence | Similarity |
|---|---|---|---|
| Apta_8 | DNA | TGTGGGGGTGGACGGGCCGGGTAGA | |
| Apta_23 | DNA | TGTGGGGGTGGACGGGCCGAGTACG | |
| Apta_673 | DNA | GCAGTCCTAGATCGGGTGTGGCTGGCTTGG | |
| Apta_63 | DNA | GACCCGTGGTAGGGTAGGATGGGGTGGTC | |
| Apta_21 | DNA | TGTGGGGGAGGACGGGCGGGGATGC | |
| Apta_24 | DNA | TGTGGGGATGGATGGGCCGGGCTGC | |
| Apta_126 | DNA | TCCTCATATAGAGTGCGGGGCGTGT | |
| Apta_389 | DNA | GCCTGTGGTGTTGGGGCGGGTGCG | |
| Apta_671 | DNA | GCATCTGATCGGGTGTGGGTGGCGTAAAGG | |
| Apta_69 | DNA | AGCGAGTAGGTTGGTGTGGTTGGGGCTCGCT | |
| Apta_72 | DNA | AGTCAGTAGGTTGGTGTGGTTGGGGCTGACT | |
| Apta_75 | DNA | CACTGGTAGGTTGGTGTGGTTGGGGCCAGTG | |
| Apta_259 | DNA | GCAAGTATGAGCGCAGGAGTTAGGTCCCGTGGCGATGGGT | |
| Apta_478 | DNA | CTTCACTTTCGTGGACGGTGGCGTCGGGGCGGTTTGTATG | |
| Apta_1065 | DNA | CCTCGCTATGATGGAGTGCGTTTAGATCAGGGAACGGGTT | |
| Apta_1257 | DNA | CGACGCACAGTCGCTGGTGCGTACCTGGTTGCCGTTGTGT | |
| Apta_1258 | DNA | GGCGAAGGAGTCATGTAGGTGTGGTCGAGACCGCTGTGCT | |
| Apta_12 | DNA | TGAGGGGGTGGGTGGGACGGGTTGG | |
| Apta_14 | DNA | AGCGGGGGGGGCTGGGCTGGGTGGG | |
| Apta_16 | DNA | AGGGGGGGGGGACGGGACGGGTATA |
DEV TOOL
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