Aptamer-target interaction descriptor
Aptamer-target interaction information
Interaction ID: 423
Aptamer sequence: GGCAGGAAGACAAACACCAGGTGAGGGAGACGACGCGAGTGTTAGATGGTAGCTGTTGGTCTGTGGTGCTGT
Target unique ID: P69892
Aptamer ID Aptamer descriptor Target chemistry Target name Affinity Binding Conditions/Buffer PubMed ID
Apta_417 Hemoglobin aptamer Protein HBG2_HUMAN 7.6 nM 10 mM Tris, 100mM NaCl, 2mM CaCl2, 1% BSA 26797251
Structure information of aptamer
Aptamer Sequence: GGCAGGAAGACAAACACCAGGTGAGGGAGACGACGCGAGTGTTAGATGGTAGCTGTTGGTCTGTGGTGCTGT
The optimal secondary structure in dot-bracket notation: ((((...((((.(((((((.......((.((.......)).))...))))....))).))))....))))..
The centroid secondary structure in dot-bracket notation: ((((...((((..((.(((...........................))).....))..))))....))))..
The MFE structure
The Centroid structure
The mountain plot representation
Aptamer information
Type Detail Type Detail
Aptamer ID Apta_417 Description Hemoglobin aptamer
Aptamer chemistry DNA Length 72 nt
GC content 55.6% Molecular weight 22,553.42 Da
Molarity of 1 μg/μl solution 44.34 μM Number of G-quadruplexes No QGRS found
G-Score N/A Function Aptasensor
Sequence GGCAGGAAGACAAACACCAGGTGAGGGAGACGACGCGAGTGTTAGATGGTAGCTGTTGGTCTGTGGTGCTGT
Applications The detection process of human whole blood
Target information
Type Detail Type Detail
Uniprot ID P69892 Protein name Hemoglobin subunit gamma-2 (Gamma-2-globin) (Hb F Ggamma) (Hemoglobin gamma-2 chain) (Hemoglobin gamma-G chain)
Gene name(s) HBG2 Organism Hemoglobin subunit gamma-2 (Gamma-2-globin) (Hb F Ggamma) (Hemoglobin gamma-2 chain) (Hemoglobin gamma-G chain)
Status reviewed in uniprot database Length 147
Mass 16,126 Activity regulation N/A
Involvement in disease Cyanosis transient neonatal (TNCY) Catalytic activity N/A
PDB ID(s)
1FDH;4MQJ;4MQK;
Function Gamma chains make up the fetal hemoglobin F, in combination with alpha chains.
Activity data

No relevant experimental diagram

 Interaction ID 423
Target type Protein
Target unique ID P69892
Activity 7.6 nM
Binding Conditions/Buffer

10 mM Tris, 100mM NaCl, 2mM CaCl2, 1% BSA
Assay

N/A
PubMed ID 26797251
Similar aptamers
Aptamer ID Aptamer chemistry Sequence Similarity
Apta_140 DNA GGCAGGAAGACAAACACGATGGGGGGGTATGATTTGATGTGGTTGTTGCATGATCGTGGTCTGTGGTGCTGT 72.22%
Apta_418 DNA TGGCAGGAAGACAAACACATCGTCGCGGCCTTAGGAGGGGCGGACGGGGGGGGGCGTGGTCTGTGGTGCTGT 66.67%
Apta_1267 DNA GGCACGGCAAAGGGGTACAGCCTACCGAACCGTGGCTGTAAGGGTGGTTGTGGTGTG 58.33%
Apta_988 DNA AAGGATGACTGACGACGATGGGAATGGAGAGGAAGGGGATATAGGTATGTTGGATGTAG 56.94%
Apta_812 DNA ATAGGAGTCACGACGACCAGAATAGAGATATGACAGCGGGGAAGGTTAAGAGGCGCTAGGAGTATGTGCGTCTACCTCTTGACTAAT 56.32%
Apta_686 DNA GGTCACCAACAACAGGGAGCGCTACGCGAAGGGTCAATGTGACGTCATGCGGATGTGTGG 55.56%
Apta_755 DNA GGGGAGGGAGACACAGTCATGGAGCAGTTATTAGGGTGTACCGGGTGTAGT 55.56%
Apta_756 DNA GGGGGACACGGAGGTGGTGGAAAGGCTAAGATTTGATGATGAGTAGTGTGGT 55.56%
Apta_1213 DNA GGACTTGAAGAAAAGGGCGACACGCGAAGTCGATGTCGCGTCTGCCTGAAGTCA 55.56%
Apta_1230 DNA GGCGATAGGCAGTGTTGCGGGGTCGGAGAGCGAGGTAATAGCGTGTATGGGTGCTGTGTG 55.56%
Apta_1178 DNA AGCGTCGAATACCACTACAGGGGATGCGAAGTTCCGCGGTCGAGTATATGATACATCCATCTAATGGAGCTCGTGGTCAG 55.00%
Apta_109 DNA AGCAGCACAGAGGTCAGATGTGCGACCACCTGGATAGACGAGGGTAGTAAGGAGTGTGTTCCTATGCGTGCTACCGTGA 54.43%
Apta_109 DNA AGCAGCACAGAGGTCAGATGTGCGACCACCTGGATAGACGAGGGTAGTAAGGAGTGTGTTCCTATGCGTGCTACCGTGA 54.43%
Apta_79 DNA ATCTCGAGTCATAGGGGGCGCGAACATACGCGGTTGGTGTGGTTGGCTGACTCGT 54.17%
Apta_568 DNA CCCAGCAGCACTGGTAGTGAGGCAGTTCACCGGTGGGGCGGTGAGTTTGGCTGCTATTTAT 54.17%
Apta_1227 DNA CACACCAAACACACAAGTGGACCCTGACGCATGGATAGGGTGACGGTATACGCGGGCATG 54.17%
Apta_1228 DNA GGCCACCAAACCACACCGTCGCAACCGCGAGAACCGAAGTAGTGATCATGTCCCTGCGTG 54.17%
Apta_1231 DNA ACCACCGGCCCGAGATAGTCTAGACCACTATGTTGTTGTGCTTACTGCTGTGTGGTGTGG 54.17%
Apta_731 DNA AAGGAGCAGCGTGGAGGATACTCTAATTGCCGTATAAGGTCAGGGGGTTGGTTGGTTCCTAGTGCTTAGGGTGTGTCGTCGTGGT 54.12%
Apta_800 DNA AAGGAGCAGCGTGGAGGATATACACCGTCATCAGAGGGAGCATCTCTAGTCAGGACTGTGATGAATTAGGGTGTGTCGTCGTGGT 54.12%

ABOUT

AptaDB is an online database we developed to integrate comprehensive information about aptamer.
The detail of this database is described here:

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