ARRY-470
(NYNZQNWKBKUAII-KBXCAEBGSA-N)
Structure
- SMILES
- O[C@H]1CCN(C1)C(=O)Nc1cnn2c1nc(cc2)N1CCC[C@@H]1c1cc(F)ccc1F
- Type(s)
- Approved; Investigational
- Molecular Formula:
- C21H22F2N6O2
- Molecular Weight:
- 428.435
- Log P:
- 3.0234
- Hydrogen Bond Acceptor:
- 8
- Hydrogen Bond Donor:
- 2
- TPSA:
- 86
- CAS Number(s):
- 1223403-58-4
Synonym(s)
1.
ARRY-470
2.
LOXO-101
3.
N-(5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo(1,5-a)pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide
4.
larotrectinib
External Link(s)
| MeSH | C000609083 |
| PubChem Compound | 46188928 |
| BindingDB | 136597 |
| CHEMBL | CHEMBL3889654 |
| DrugBank | DB14723 |
| IUPHAR/BPS Guide to PHARMACOLOGY | 8909 |
| KEGG | dr:D11137 |
| ZINC | 118399834 |
Adverse Drug Event(s)
| Name | Number of Reports | Reference(s) | Data Source | |
|---|---|---|---|---|
| 1 | Dizziness | FAERS: 4 | US FAERS | |
| 2 | Fatigue | FAERS: 3 | US FAERS | |
| 3 | Disease Progression | FAERS: 2 | US FAERS | |
| 4 | Lethargy | FAERS: 2 | US FAERS | |
| 5 | Pneumonia | FAERS: 2 | US FAERS | |
| 6 | Pneumothorax | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 7 | Product use in unapproved indication | FAERS: 2 | US FAERS | |
| 8 | Alanine Aminotransferase Increased | FAERS: 1 | US FAERS | |
| 9 | Amyotrophic Lateral Sclerosis | FAERS: 1 | US FAERS | |
| 10 | Cellulitis | FAERS: 1 | US FAERS | |
| 11 | Drug ineffective | FAERS: 1 | US FAERS | |
| 12 | Hernia | FAERS: 1 | US FAERS | |
| 13 | Hypersomnia | FAERS: 1 | US FAERS | |
| 14 | Hypotension | FAERS: 1 | US FAERS | |
| 15 | Leukopenia | FAERS: 1 | US FAERS | |
| 16 | Myalgia | FAERS: 1 | US FAERS | |
| 17 | Nausea | FAERS: 1 | US FAERS | |
| 18 | Neck Pain | FAERS: 1 | US FAERS | |
| 19 | Oropharyngeal pain | FAERS: 1 | US FAERS | |
| 20 | Pain | FAERS: 1 | US FAERS | |
| 21 | Peripheral swelling | FAERS: 1 | US FAERS | |
| 22 | Pruritus | FAERS: 1 | US FAERS | |
| 23 | Restless Legs Syndrome | FAERS: 1 | US FAERS | |
| 24 | Sensitive skin | FAERS: 1 | US FAERS | |
| 25 | Sepsis | FAERS: 1 | US FAERS | |
| 26 | Tremor | FAERS: 1 | US FAERS | |
| 27 | nervous system disorder | FAERS: 1 | US FAERS |
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