AP26113
(AILRADAXUVEEIR-UHFFFAOYSA-N)
Structure
- SMILES
- COc1cc(ccc1Nc1ncc(c(n1)Nc1ccccc1P(=O)(C)C)Cl)N1CCC(CC1)N1CCN(CC1)C
- Type(s)
- Approved; Investigational
- ATC code(s)
- L01XE43
- Molecular Formula:
- C29H39ClN7O2P
- Molecular Weight:
- 584.092
- Log P:
- 5.1768
- Hydrogen Bond Acceptor:
- 7
- Hydrogen Bond Donor:
- 2
- TPSA:
- 95.67
- CAS Number(s):
- 1197953-54-0
Synonym(s)
1.
AP26113
2.
brigatinib
External Link(s)
| MeSH | C000598580 |
| PubChem Compound | 68165256 |
| BindingDB | 50185140 |
| CHEMBL | CHEMBL3545311 |
| DrugBank | DB12267 |
| DrugCentral | 5233 |
| KEGG | dr:D10866 |
| ZINC | 148723177 |
Adverse Drug Event(s)
| Name | Number of Reports | Reference(s) | Data Source | |
|---|---|---|---|---|
| 1 | Drug ineffective | FAERS: 21 | US FAERS | |
| 2 | Fatigue | FAERS: 11 | US FAERS | |
| 3 | Nausea | FAERS: 8 | US FAERS | |
| 4 | Asthenia | FAERS: 6 | US FAERS | |
| 5 | Blood creatine phosphokinase increased | FAERS: 6 | US FAERS | |
| 6 | Constipation | FAERS: 6 | US FAERS | |
| 7 | Pain | FAERS: 6 | US FAERS | |
| 8 | Somnolence | FAERS: 6 | US FAERS | |
| 9 | Discomfort | FAERS: 5 | US FAERS | |
| 10 | Malaise | FAERS: 5 | US FAERS | |
| 11 | Memory impairment | FAERS: 5 | US FAERS | |
| 12 | Vomiting | FAERS: 5 | US FAERS | |
| 13 | Abdominal Pain | FAERS: 4 | US FAERS | |
| 14 | Cerebrovascular accident | FAERS: 4 | US FAERS | |
| 15 | Feeling abnormal | FAERS: 4 | US FAERS | |
| 16 | Alanine Aminotransferase Increased | FAERS: 3 | US FAERS | |
| 17 | Dehydration | FAERS: 3 | US FAERS | |
| 18 | Depressed mood | FAERS: 3 | US FAERS | |
| 19 | Emotional distress | FAERS: 3 | US FAERS | |
| 20 | Headache | FAERS: 3 | US FAERS | |
| 21 | Myalgia | FAERS: 3 | US FAERS | |
| 22 | Oropharyngeal pain | FAERS: 3 | US FAERS | |
| 23 | Tachycardia | FAERS: 3 | US FAERS | |
| 24 | Adverse event | FAERS: 2 | US FAERS | |
| 25 | Aspartate Aminotransferase Increased | FAERS: 2 | US FAERS | |
| 26 | Blepharitis | FAERS: 2 | US FAERS | |
| 27 | Blood cholesterol increased | FAERS: 2 | US FAERS | |
| 28 | Blood sodium decreased | FAERS: 2 | US FAERS | |
| 29 | Disease Progression | FAERS: 2 | US FAERS | |
| 30 | Erythema | FAERS: 2 | US FAERS | |
| 31 | General physical health deterioration | FAERS: 2 | US FAERS | |
| 32 | Hypersensitivity | FAERS: 2 | US FAERS | |
| 33 | Infection | FAERS: 2 | US FAERS | |
| 34 | Nasopharyngitis | FAERS: 2 | US FAERS | |
| 35 | Palpitations | FAERS: 2 | US FAERS | |
| 36 | Pneumonia | FAERS: 2 | US FAERS | |
| 37 | Pneumonitis | FAERS: 2 | US FAERS | |
| 38 | Product dose omission | FAERS: 2 | US FAERS | |
| 39 | Pruritus | FAERS: 2 | US FAERS | |
| 40 | Radiation necrosis | FAERS: 2 | US FAERS | |
| 41 | Respiratory Failure | FAERS: 2 | US FAERS | |
| 42 | Sepsis | FAERS: 2 | US FAERS | |
| 43 | Abdominal discomfort | FAERS: 1 | US FAERS | |
| 44 | Acid peptic disease | FAERS: 1 | US FAERS | |
| 45 | Acute respiratory failure | FAERS: 1 | US FAERS | |
| 46 | Adenocarcinoma | FAERS: 1 | US FAERS | |
| 47 | Alopecia | FAERS: 1 | US FAERS | |
| 48 | Amnesia | FAERS: 1 | US FAERS | |
| 49 | Amylase increased | FAERS: 1 | US FAERS | |
| 50 | Angioedema | FAERS: 1 | US FAERS | |
| 51 | Aphasia | FAERS: 1 | US FAERS | |
| 52 | Aphonia | FAERS: 1 | US FAERS | |
| 53 | Apparent death | FAERS: 1 | US FAERS | |
| 54 | Ascites | FAERS: 1 | US FAERS | |
| 55 | Blindness | FAERS: 1 | US FAERS | |
| 56 | Blood alkaline phosphatase increased | FAERS: 1 | US FAERS | |
| 57 | Bronchitis | FAERS: 1 | US FAERS | |
| 58 | Cardiac dysfunction | FAERS: 1 | US FAERS | |
| 59 | Chest Pain | FAERS: 1 | US FAERS | |
| 60 | Chills | FAERS: 1 | US FAERS | |
| 61 | Deafness | FAERS: 1 | US FAERS | |
| 62 | Dizziness | FAERS: 1 | US FAERS | |
| 63 | Dysgeusia | FAERS: 1 | US FAERS | |
| 64 | Febrile Neutropenia | FAERS: 1 | US FAERS | |
| 65 | Hemiparesis | FAERS: 1 | US FAERS | |
| 66 | Hemiplegia | FAERS: 1 | US FAERS | |
| 67 | Hepatomegaly | FAERS: 1 | US FAERS | |
| 68 | Hypotension | FAERS: 1 | US FAERS | |
| 69 | Intestinal Obstruction | FAERS: 1 | US FAERS | |
| 70 | Intestinal metastasis | FAERS: 1 | US FAERS | |
| 71 | Intracranial mass | FAERS: 1 | US FAERS | |
| 72 | Laryngitis | FAERS: 1 | US FAERS | |
| 73 | Lipase increased | FAERS: 1 | US FAERS | |
| 74 | Lower respiratory tract infection | FAERS: 1 | US FAERS | |
| 75 | Lung consolidation | FAERS: 1 | US FAERS | |
| 76 | Metastasis | FAERS: 1 | US FAERS | |
| 77 | Musculoskeletal Pain | FAERS: 1 | US FAERS | |
| 78 | Neck Pain | FAERS: 1 | US FAERS | |
| 79 | Neuralgia | FAERS: 1 | US FAERS | |
| 80 | Overdose | FAERS: 1 | US FAERS | |
| 81 | Pathological fracture | FAERS: 1 | US FAERS | |
| 82 | Pericardial effusion | FAERS: 1 | US FAERS | |
| 83 | Prescribed overdose | FAERS: 1 | US FAERS | |
| 84 | Pulmonary Embolism | FAERS: 1 | US FAERS | |
| 85 | Pulmonary arterial hypertension | FAERS: 1 | US FAERS | |
| 86 | Pulmonary renal syndrome | FAERS: 1 | US FAERS | |
| 87 | Septic Shock | FAERS: 1 | US FAERS | |
| 88 | Sinus Tachycardia | FAERS: 1 | US FAERS | |
| 89 | Surgical failure | FAERS: 1 | US FAERS | |
| 90 | Therapy non-responder | FAERS: 1 | US FAERS | |
| 91 | Transaminases increased | FAERS: 1 | US FAERS | |
| 92 | Weight decreased | FAERS: 1 | US FAERS | |
| 93 | White blood cell count decreased | FAERS: 1 | US FAERS | |
| 94 | nervous system disorder | FAERS: 1 | US FAERS |
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