Aptamer-target interaction descriptor
Aptamer-target interaction information
Interaction ID: 881
Aptamer sequence: GTTCGTGGTGTGCTGGATGTCACCTCCACTCACCACCTCTTCTCCGCTCCTCGTCATGACACATCCAGCAGCACGA
Target unique ID: CRL-2945
| Aptamer ID | Aptamer descriptor | Target chemistry | Target name | Affinity | Binding Conditions/Buffer | PubMed ID |
|---|---|---|---|---|---|---|
| Apta_797 | Apoc46 | Cell | Primary serous ovarian cancer (pSOC) cells | 0.11 μM | PBS | 33787226 |
Structure information of aptamer
| Aptamer Sequence: | GTTCGTGGTGTGCTGGATGTCACCTCCACTCACCACCTCTTCTCCGCTCCTCGTCATGACACATCCAGCAGCACGA |
| The optimal secondary structure in dot-bracket notation: | ..(((((...((((((((((........................................)))))))))).))))) |
| The centroid secondary structure in dot-bracket notation: | ..(((((...(((((((((((....................................)..)))))))))).))))) |
The MFE structure
The Centroid structure
The mountain plot representation
Aptamer information
| Type | Detail | Type | Detail |
|---|---|---|---|
| Aptamer ID | Apta_797 | Description | Apoc46 |
| Aptamer chemistry | DNA | Length | 76 nt |
| GC content | 57.9% | Molecular weight | 23,113.76 Da |
| Molarity of 1 μg/μl solution | 43.26 μM | Number of G-quadruplexes | No QGRS found |
| G-Score | N/A | Function | Targeted therapy |
| Sequence | GTTCGTGGTGTGCTGGATGTCACCTCCACTCACCACCTCTTCTCCGCTCCTCGTCATGACACATCCAGCAGCACGA | ||
| Applications | Molecular tools for rapid intraoperative diagnosis and In vivo imaging of serous ovarian cancer | ||
Target information
| Type | Detail | Type | Detail |
|---|---|---|---|
| ATCC ID | CRL-2945 | Cell name | Primary serous ovarian cancer (pSOC) cells |
| Category | Human cells | Organism | Homo sapiens, human |
| Product type | N/A | Cell type | N/A |
| Morphology | epithelial-like | Tissue | Ovary |
| Disease | Carcinoma | Product format | Frozen |
| Antigen expression | Cytokeratin 7 (CK-7), positive; calretinin, positive | Genes expressed | p53; cytokeratin 7 (CK-7) positive; calretinin positive; Wilms' tumor protein (WT) positive; BRCA1 negative |
| Cell description | N/A |
|
|
| Application(s) | 3D cell culture; Cancer research | ||
Activity data
|
No relevant experimental diagram |
Interaction ID | 881 |
| Target type | Cell | |
| Target unique ID | CRL-2945 | |
| Activity | 0.11 μM | |
| Binding Conditions/Buffer | PBS |
|
| Assay | N/A |
|
| PubMed ID | 33787226 |
Similar aptamers
| Aptamer ID | Aptamer chemistry | Sequence | Similarity |
|---|---|---|---|
| Apta_799 | DNA | GTTCGTGGTGTGCTGGATGTCCCGTGCACGGCGCCACGTTTTCCTCTCATCCCCGATGACACATCCAGCAGCACGA | |
| Apta_796 | DNA | GTGCTGGATGTCACCTCCACTCACCACCTCTTCTCCGCTCCTCGTCATGACACATCCAG | |
| Apta_798 | DNA | GTTCGTGGTGTGCTGGATGTCGGAGATGGTCCGCTTCGTTCAACTACTACGCATTTTGACACATCCAGCAGCACGA | |
| Apta_435 | DNA | CCTTCGTTGTCTGCCTTCGTAGGACCGCAGACATCGACGCAGGGAAATTCCGCAAGTCCAGCCAAATGCCACCCTTCAGAATTCGCACCA | |
| Apta_1072 | DNA | TTGAAGTGACTCCCACCCCGCCCCACCGTCCTTGCCACCGTTCCGCCATAGCAGGT | |
| Apta_665 | DNA | CGCCAATCTCAAAGCCCGCCACCTGCCCCTCACTGCCCACCTGTGGAATCCATGTCGCTC | |
| Apta_687 | DNA | GGGACAGCGGAGGTCTCCCACCCACCGGCCCCTGCGGCACACCAACCTGTATGGATGCG | |
| Apta_688 | DNA | GCCATGACAACCAGAGGTACCCCCGCCCACCAGCCCCGAAGTCTGTCAGCCTAGTTGTTG | |
| Apta_694 | DNA | ACTCACTATGGAAGAGATGGCGACATCTCTTCTCCGAGCCGGTCGAAATAGTGAGT | |
| Apta_734 | DNA | TCCTCGATGCACCAGTTCACCTTATTTGCTTCTTCTCTCTGTTCTGACTGGGTGCTGAGGA | |
| Apta_995 | DNA | GCAATGGTACGGTACTTCCCCACCCCACGCTGCTCCCAAAAGTGCACGCTACTTTGCTAA | |
| Apta_1108 | DNA | GTGCTTAGGTGCAGAACGCACACACGCTCGGTATGACGTGTTCGCTACGGTATAATTGCAGGCGCGAGCACAACAG | |
| Apta_1233 | DNA | TCACGAGAGAGCGAGAGCGCCCCCCCACCACAGCCGTCACCACCCTATTCCTCTGCCGTTG | |
| Apta_698 | DNA | AGCAGCACAGAGGTCAGATGCACTCGGACCCCATTCTCCTTCCATCCCTCATCCGTCCACCCTATGCGTGCTACCGTGAA | |
| Apta_863 | DNA | CTCCTCTGACTGTAACCACGCCCAGAAACAGCACCCTTACATCGACTGGACCTTCCGCGGCATAGGTAGTCCAGAAGCC | |
| Apta_934 | DNA | GACGCTTACTCAGGTGTGACTCGTGAACCCACCTCAGGGCATCTTACATTTCTTCTAAGTTGTTACCATGTTTCGAAGGACGCAGATGAAGTCTC | |
| Apta_614 | DNA | AATCGCATTACCTTATACCAGCTTATTCAATTACGTCTGCACATACCAGCTTATTCAATT | |
| Apta_662 | DNA | GGCGCCAAACAGGACCACCATGACAATTACCCATACCACCTCATTATGCCCCATCTCCGC | |
| Apta_704 | DNA | GTACGAATTCACGAGGTTGCCAGCGGGGCCAGCCACTTCTGTCAGTGAATTCCTGCTCGTATATCTACTCGCCCGCCTGCGAGCATGGAGTCGGATCCTCTA | |
| Apta_726 | DNA | TACCAGTGCGATGCTCAGGCCGATGTCAACTTTTTCTAACTCACTGGTTTTGCCTGACGCATTCGGTTGAC |
DEV TOOL
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