MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

alvimopan

(UPNUIXSCZBYVBB-JVFUWBCBSA-N)

Structure

SMILES: OC(=O)CNC(=O)[C@@H](Cc1ccccc1)CN1CC[C@@]([C@H](C1)C)(C)c1cccc(c1)O
Type(s): Approved; Investigational
ATC code(s): A06AH02
Molecular Formula:: C25H32N2O4
Molecular Weight:: 424.533
Log P:: 3.3802
Hydrogen Bond Acceptor:: 6
Hydrogen Bond Donor:: 3
TPSA:: 89.87
CAS Number(s):: 145590-44-9; 156053-89-3

Synonym(s)

alvimopan

ADL 8-2698

ADL8-2698

Entereg

LY 246736

LY-246736

LY246736

alvimopan anhydrous

anhydrous alvimopan

10.

trans-3,4-dimethyl-4-(3-hydroxyphenyl) piperidine

External Link(s)

MeSH	C419502
PubChem Compound	51397022 5488548
BindingDB	50088381
ChEBI	135686
CHEMBL	CHEMBL270190
DrugBank	DB06274
DrugCentral	143
IUPHAR/BPS Guide to PHARMACOLOGY	7471
KEGG	dr:D02878
Therapeutic Target Database	D0D7KC
ZINC	3802417

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Acute myocardial infarction	FAERS: 5		OFFSIDES US FAERS
2	Atrial Fibrillation	FAERS: 1		US FAERS
3	Cerebrovascular accident	FAERS: 1		US FAERS
4	Drug dose omission	FAERS: 1		US FAERS
5	Intestinal infarction	FAERS: 1		US FAERS
6	Unevaluable event	FAERS: 1		US FAERS
7	Ventricular Fibrillation	FAERS: 1		OFFSIDES US FAERS
8	Abdominal Pain		18164818	CTD OFFSIDES
9	Abdominal discomfort			OFFSIDES
10	Acute Coronary Syndrome			OFFSIDES
11	Anastomotic Leak			OFFSIDES
12	Anastomotic complication			OFFSIDES
13	Aortic valve calcification			OFFSIDES
14	Aortic valve sclerosis			OFFSIDES
15	Back Pain			SIDER
16	Blood and lymphatic system disorders			SIDER
17	Blood glucose decreased			OFFSIDES
18	Blood pressure inadequately controlled			OFFSIDES
19	Carotid pulse increased			OFFSIDES
20	Choking sensation			OFFSIDES
21	Clostridium difficile colitis			OFFSIDES
22	Colectomy			OFFSIDES
23	Congenital tricuspid valve incompetence			OFFSIDES
24	Constipation		18164818 21292168 21292169	CTD SIDER
25	Diarrhea		18164818	CTD OFFSIDES
26	Dyspepsia			SIDER
27	Flatulence			SIDER
28	Gastrointestinal Diseases		11180040	CTD
29	Gastrointestinal disorder postoperative			OFFSIDES
30	Gastrointestinal perforation			OFFSIDES
31	Gastrointestinal stoma complication			OFFSIDES
32	Hypercapnia			OFFSIDES
33	Ileus		View details 17042776 17382220 17435541 17950339 18694369 19086236 20526599 21292168 21292169 21552060 22196657	CTD
34	Infection			OFFSIDES
35	Intentional drug misuse			OFFSIDES
36	Intestinal Obstruction			OFFSIDES
37	Leukopenia neonatal			OFFSIDES
38	Malnutrition			SIDER
39	Mental status changes			OFFSIDES
40	Nausea		18164818	CTD OFFSIDES
41	Portal Vein Thrombosis			OFFSIDES
42	Post procedural complication			OFFSIDES
43	Post procedural myocardial infarction			OFFSIDES
44	Post procedural pulmonary embolism			OFFSIDES
45	Postoperative Complications		View details 17042776 17382220 17435541 17950339 18694369 19086236 19209278 20526599 21292168 21292169 21552060 21572777 22196657	CTD
46	Postoperative renal failure			OFFSIDES
47	Procedural complication			OFFSIDES
48	Procedural hypotension			OFFSIDES
49	Respiratory Failure			OFFSIDES
50	Septic Shock			OFFSIDES
51	Silent myocardial infarction			OFFSIDES
52	Supraventricular tachycardia			OFFSIDES
53	Troponin increased			OFFSIDES
54	Urinary Retention			SIDER

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