Doxepin
(MHNSPTUQQIYJOT-SJDTYFKWSA-N)
Structure
- SMILES
- CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C.Cl
- Molecular Formula:
- C19H22ClNO
- Molecular Weight:
- 315.837
- Log P:
- 4.7644
- Hydrogen Bond Acceptor:
- 2
- Hydrogen Bond Donor:
- 1
- TPSA:
- 12.47
- CAS Number(s):
- 1229-29-4; 4698-39-9
Synonym(s)
1.
Doxepin
2.
Apo-Doxepin
3.
Aponal
4.
Deptran
5.
Desidox
6.
Doneurin
7.
Doxepia
8.
Doxepin Hydrochloride
9.
Doxepin Hydrochloride, Cis-Trans Isomer Mixture (approximately 1:5)
10.
Doxepin beta
11.
Doxepin-RPh
12.
Espadox
13.
Mareen
14.
Novo-Doxepin
15.
Prudoxin
16.
Quitaxon
17.
Sinequan
18.
Sinquan
19.
Xepin
20.
Zonalon
21.
Apo Doxepin
22.
ApoDoxepin
23.
Doxepin RPh
24.
Hydrochloride, Doxepin
25.
Novo Doxepin
External Link(s)
Adverse Drug Event(s)
| Name | Number of Reports | Reference(s) | Data Source | |
|---|---|---|---|---|
| 1 | Drug ineffective | FAERS: 59 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 2 | Completed Suicide | FAERS: 40 Canada Vigilance: 8 | Canada Vigilance US FAERS | |
| 3 | Somnolence | FAERS: 22 Canada Vigilance: 3 | Canada Vigilance US FAERS | |
| 4 | Overdose | FAERS: 16 | US FAERS | |
| 5 | Respiratory arrest | FAERS: 14 | US FAERS | |
| 6 | Headache | FAERS: 13 | US FAERS | |
| 7 | Cardiac Arrest | FAERS: 12 | US FAERS | |
| 8 | Toxicity to various agents | FAERS: 11 | US FAERS | |
| 9 | Drug ineffective for unapproved indication | FAERS: 10 | US FAERS | |
| 10 | Fatigue | FAERS: 10 | US FAERS | |
| 11 | Dizziness | FAERS: 9 | US FAERS | |
| 12 | Drug toxicity | FAERS: 7 | US FAERS | |
| 13 | Feeling abnormal | FAERS: 7 | US FAERS | |
| 14 | Nausea | FAERS: 7 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 15 | Respiratory Depression | FAERS: 7 | US FAERS | |
| 16 | Drug abuse | FAERS: 6 | US FAERS | |
| 17 | Pruritus | FAERS: 5 | US FAERS | |
| 18 | Reaction to drug excipients | FAERS: 5 | US FAERS | |
| 19 | Suicide attempt | FAERS: 5 | US FAERS | |
| 20 | Accidental exposure | FAERS: 4 | US FAERS | |
| 21 | Acute kidney injury | FAERS: 4 | US FAERS | |
| 22 | Anxiety | FAERS: 4 | US FAERS | |
| 23 | Asthenia | FAERS: 4 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 24 | Depressed Level of Consciousness | FAERS: 4 | US FAERS | |
| 25 | Drug dispensing error | FAERS: 4 | US FAERS | |
| 26 | Medication Error | FAERS: 4 | US FAERS | |
| 27 | Poisoning | FAERS: 4 | US FAERS | |
| 28 | Tachycardia | FAERS: 4 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 29 | Tremor | FAERS: 4 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 30 | Blood alcohol increased | FAERS: 3 | US FAERS | |
| 31 | Chest Pain | FAERS: 3 | US FAERS | |
| 32 | Exposure during breast feeding | FAERS: 3 | US FAERS | |
| 33 | Hypersensitivity | FAERS: 3 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 34 | Hypotension | FAERS: 3 | US FAERS | |
| 35 | Malaise | FAERS: 3 | US FAERS | |
| 36 | No adverse event | FAERS: 3 | US FAERS | |
| 37 | Oropharyngeal pain | FAERS: 3 | US FAERS | |
| 38 | Product use in unapproved indication | FAERS: 3 | US FAERS | |
| 39 | Radiation injury | FAERS: 3 | US FAERS | |
| 40 | Rhabdomyolysis | FAERS: 3 | US FAERS | |
| 41 | Urticaria | FAERS: 3 | US FAERS | |
| 42 | Vomiting | FAERS: 3 | US FAERS | |
| 43 | Accidental overdose | FAERS: 2 | US FAERS | |
| 44 | Alopecia | FAERS: 2 | US FAERS | |
| 45 | Antidepressant drug level decreased | FAERS: 2 | US FAERS | |
| 46 | Antidepressant drug level increased | FAERS: 2 | US FAERS | |
| 47 | Blood glucose increased | FAERS: 2 | US FAERS | |
| 48 | Chest discomfort | FAERS: 2 | US FAERS | |
| 49 | Cold sweat | FAERS: 2 | US FAERS | |
| 50 | Constipation | FAERS: 2 | US FAERS | |
| 51 | Dehydration | FAERS: 2 | US FAERS | |
| 52 | Drug prescribing error | FAERS: 2 | US FAERS | |
| 53 | Dysarthria | FAERS: 2 | US FAERS | |
| 54 | Erythema | FAERS: 2 | US FAERS | |
| 55 | Facial Pain | FAERS: 2 | US FAERS | |
| 56 | Inflammation | FAERS: 2 | US FAERS | |
| 57 | Intentional product use issue | FAERS: 2 | US FAERS | |
| 58 | Lethargy | FAERS: 2 | US FAERS | |
| 59 | Leukocytosis | FAERS: 2 | US FAERS | |
| 60 | Metabolic acidosis | FAERS: 2 | US FAERS | |
| 61 | Myocardial Infarction | FAERS: 2 | US FAERS | |
| 62 | Peripheral swelling | FAERS: 2 | US FAERS | |
| 63 | Poor quality sleep | FAERS: 2 | US FAERS | |
| 64 | Product dispensing error | FAERS: 2 | US FAERS | |
| 65 | Product physical issue | FAERS: 2 | US FAERS | |
| 66 | Product use issue | FAERS: 2 | US FAERS | |
| 67 | Somnambulism | FAERS: 2 | US FAERS | |
| 68 | Swelling | FAERS: 2 | US FAERS | |
| 69 | Tinnitus | FAERS: 2 | US FAERS | |
| 70 | Vertigo | FAERS: 2 | US FAERS | |
| 71 | Wrong drug administered | FAERS: 2 | US FAERS | |
| 72 | Wrong technique in drug usage process | FAERS: 2 | US FAERS | |
| 73 | Abdominal Pain | FAERS: 1 | US FAERS | |
| 74 | Abdominal discomfort | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 75 | Ageusia | FAERS: 1 | US FAERS | |
| 76 | Agitation | FAERS: 1 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 77 | Akathisia | FAERS: 1 | US FAERS | |
| 78 | Allergic reaction to excipient | FAERS: 1 | US FAERS | |
| 79 | Amnesia | FAERS: 1 | US FAERS | |
| 80 | Angioedema | FAERS: 1 | US FAERS | |
| 81 | Ankle Fracture | FAERS: 1 | US FAERS | |
| 82 | Anosmia | FAERS: 1 | US FAERS | |
| 83 | Antidepressant drug level above therapeutic | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 84 | Application site discharge | FAERS: 1 | US FAERS | |
| 85 | Ataxia | FAERS: 1 | US FAERS | |
| 86 | Bowel movement irregularity | FAERS: 1 | US FAERS | |
| 87 | Cardiac Flutter | FAERS: 1 | US FAERS | |
| 88 | Cerebrovascular accident | FAERS: 1 | US FAERS | |
| 89 | Chills | FAERS: 1 | US FAERS | |
| 90 | Crying | FAERS: 1 | US FAERS | |
| 91 | Disorientation | FAERS: 1 | US FAERS | |
| 92 | Drug administered to patient of inappropriate age | FAERS: 1 | US FAERS | |
| 93 | Dry skin | FAERS: 1 | US FAERS | |
| 94 | Dysgeusia | FAERS: 1 | US FAERS | |
| 95 | Dystonia | FAERS: 1 | US FAERS | |
| 96 | Dysuria | FAERS: 1 | US FAERS | |
| 97 | Erectile dysfunction | FAERS: 1 | US FAERS | |
| 98 | Exposure via breast milk | FAERS: 1 | US FAERS | |
| 99 | Eye pain | FAERS: 1 | US FAERS | |
| 100 | Fibrosis | FAERS: 1 | US FAERS | |
| 101 | Flatulence | FAERS: 1 | US FAERS | |
| 102 | Flushing | FAERS: 1 | US FAERS | |
| 103 | Gastrointestinal sounds abnormal | FAERS: 1 | US FAERS | |
| 104 | Gastrointestinal stoma complication | FAERS: 1 | US FAERS | |
| 105 | Head discomfort | FAERS: 1 | US FAERS | |
| 106 | Hunger | FAERS: 1 | US FAERS | |
| 107 | Hypersomnia | FAERS: 1 | US FAERS | |
| 108 | Hyporeflexia | FAERS: 1 | US FAERS | |
| 109 | Incorrect product administration duration | FAERS: 1 | US FAERS | |
| 110 | Infection | FAERS: 1 | US FAERS | |
| 111 | Initial insomnia | FAERS: 1 | US FAERS | |
| 112 | Intercepted drug dispensing error | FAERS: 1 | US FAERS | |
| 113 | Joint swelling | FAERS: 1 | US FAERS | |
| 114 | Lymphadenopathy | FAERS: 1 | US FAERS | |
| 115 | Mental impairment | FAERS: 1 | US FAERS | |
| 116 | Middle insomnia | FAERS: 1 | US FAERS | |
| 117 | Mood swings | FAERS: 1 | US FAERS | |
| 118 | Multiple drug overdose | FAERS: 1 | US FAERS | |
| 119 | Multiple drug overdose accidental | FAERS: 1 | US FAERS | |
| 120 | Muscle tightness | FAERS: 1 | US FAERS | |
| 121 | Myalgia | FAERS: 1 | US FAERS | |
| 122 | Nervousness | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 123 | Neurotransmitter level altered | FAERS: 1 | US FAERS | |
| 124 | Night sweats | FAERS: 1 | US FAERS | |
| 125 | Nocturia | FAERS: 1 | US FAERS | |
| 126 | Nystagmus | FAERS: 1 | US FAERS | |
| 127 | Pallor | FAERS: 1 | US FAERS | |
| 128 | Palpitations | FAERS: 1 | US FAERS | |
| 129 | Paranoia | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 130 | Pelvic Pain | FAERS: 1 | US FAERS | |
| 131 | Pharmaceutical product complaint | FAERS: 1 | US FAERS | |
| 132 | Poor sucking reflex | FAERS: 1 | US FAERS | |
| 133 | Presyncope | FAERS: 1 | US FAERS | |
| 134 | Product dose omission | FAERS: 1 | US FAERS | |
| 135 | Product preparation error | FAERS: 1 | US FAERS | |
| 136 | Product quality issue | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 137 | Rectal spasm | FAERS: 1 | US FAERS | |
| 138 | Renal pain | FAERS: 1 | US FAERS | |
| 139 | Respiratory Failure | FAERS: 1 | US FAERS | |
| 140 | Restlessness | FAERS: 1 | US FAERS | |
| 141 | Rotator cuff syndrome | FAERS: 1 | US FAERS | |
| 142 | Screaming | FAERS: 1 | US FAERS | |
| 143 | Skin reaction | FAERS: 1 | US FAERS | |
| 144 | Sopor | FAERS: 1 | US FAERS | |
| 145 | Syncope | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 146 | Therapeutic response unexpected | FAERS: 1 | US FAERS | |
| 147 | Therapeutic response unexpected with drug substitution | FAERS: 1 | US FAERS | |
| 148 | Thirst | FAERS: 1 | US FAERS | |
| 149 | Throat irritation | FAERS: 1 | US FAERS | |
| 150 | Thyroidectomy | FAERS: 1 | US FAERS | |
| 151 | Transaminases increased | FAERS: 1 | US FAERS | |
| 152 | Trismus | FAERS: 1 | US FAERS | |
| 153 | Urinary Incontinence | FAERS: 1 | US FAERS | |
| 154 | Urinary Retention | FAERS: 1 | US FAERS | |
| 155 | Visual Impairment | FAERS: 1 | US FAERS | |
| 156 | Weight decreased | FAERS: 1 | US FAERS | |
| 157 | Wheezing | FAERS: 1 | US FAERS | |
| 158 | Wrong technique in product usage process | FAERS: 1 | US FAERS | |
| 159 | Dyspepsia | Canada Vigilance: 1 | Canada Vigilance | |
| 160 | Intentional product misuse | Canada Vigilance: 1 | Canada Vigilance | |
| 161 | Limb discomfort | Canada Vigilance: 1 | Canada Vigilance | |
| 162 | Mydriasis | Canada Vigilance: 1 | Canada Vigilance | |
| 163 | Petechiae | Canada Vigilance: 1 | Canada Vigilance | |
| 164 | Sedation complication | Canada Vigilance: 1 | Canada Vigilance | |
| 165 | Supraventricular tachycardia | Canada Vigilance: 1 | Canada Vigilance |
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