N-(4-(3-chloro-4-(2-pyridinylmethoxy)anilino)-3-cyano-7-ethoxy-6-quinolyl)-4-(dimethylamino)-2-butenamide
(JWNPDZNEKVCWMY-VQHVLOKHSA-N)
Structure
- SMILES
- CCOc1cc2ncc(c(c2cc1NC(=O)/C=C/CN(C)C)Nc1ccc(c(c1)Cl)OCc1ccccn1)C#N
- Type(s)
- Approved; Investigational
- ATC code(s)
- L01XE45
- Molecular Formula:
- C30H29ClN6O3
- Molecular Weight:
- 557.043
- Log P:
- 6.0785
- Hydrogen Bond Acceptor:
- 8
- Hydrogen Bond Donor:
- 2
- TPSA:
- 112.4
- CAS Number(s):
- 698387-09-6; 876310-02-0
Synonym(s)
1.
N-(4-(3-chloro-4-(2-pyridinylmethoxy)anilino)-3-cyano-7-ethoxy-6-quinolyl)-4-(dimethylamino)-2-butenamide
2.
HKI 272
3.
HKI-272
4.
HKI272
5.
neratinib
External Link(s)
Adverse Drug Event(s)
| Name | Number of Reports | Reference(s) | Data Source | |
|---|---|---|---|---|
| 1 | Nausea | FAERS: 167 | US FAERS | |
| 2 | Fatigue | FAERS: 155 | US FAERS | |
| 3 | Vomiting | FAERS: 78 | US FAERS | |
| 4 | Constipation | FAERS: 70 | US FAERS | |
| 5 | Abdominal Pain | FAERS: 44 | US FAERS | |
| 6 | Drug dose omission | FAERS: 42 | US FAERS | |
| 7 | Headache | FAERS: 31 | US FAERS | |
| 8 | Abdominal discomfort | FAERS: 27 | US FAERS | |
| 9 | Dizziness | FAERS: 27 | US FAERS | |
| 10 | Dehydration | FAERS: 26 | US FAERS | |
| 11 | Dyspepsia | FAERS: 22 | US FAERS | |
| 12 | Weight decreased | FAERS: 20 | US FAERS | |
| 13 | Malaise | FAERS: 15 | US FAERS | |
| 14 | Acne | FAERS: 13 | US FAERS | |
| 15 | Asthenia | FAERS: 12 | US FAERS | |
| 16 | Stomatitis | FAERS: 12 | US FAERS | |
| 17 | Arthralgia | FAERS: 11 | US FAERS | |
| 18 | Dry skin | FAERS: 11 | US FAERS | |
| 19 | Blood potassium decreased | FAERS: 10 | US FAERS | |
| 20 | Dysgeusia | FAERS: 10 | US FAERS | |
| 21 | Incorrect dose administered | FAERS: 10 | US FAERS | |
| 22 | Pain | FAERS: 9 | US FAERS | |
| 23 | Urinary tract infection | FAERS: 8 | US FAERS | |
| 24 | Somnolence | FAERS: 7 | US FAERS | |
| 25 | Drug administration error | FAERS: 6 | US FAERS | |
| 26 | Feeling abnormal | FAERS: 6 | US FAERS | |
| 27 | Myalgia | FAERS: 6 | US FAERS | |
| 28 | Nasopharyngitis | FAERS: 6 | US FAERS | |
| 29 | Peripheral swelling | FAERS: 6 | US FAERS | |
| 30 | Acute kidney injury | FAERS: 5 | US FAERS | |
| 31 | Erythema | FAERS: 5 | US FAERS | |
| 32 | Flatulence | FAERS: 5 | US FAERS | |
| 33 | Gastrointestinal sounds abnormal | FAERS: 5 | US FAERS | |
| 34 | Hypotension | FAERS: 5 | US FAERS | |
| 35 | Product dose omission | FAERS: 5 | US FAERS | |
| 36 | White blood cell count decreased | FAERS: 5 | US FAERS | |
| 37 | Back Pain | FAERS: 4 | US FAERS | |
| 38 | Onychoclasis | FAERS: 4 | US FAERS | |
| 39 | Alopecia | FAERS: 3 | US FAERS | |
| 40 | Anxiety | FAERS: 3 | US FAERS | |
| 41 | Dermatitis acneiform | FAERS: 3 | US FAERS | |
| 42 | Drug ineffective | FAERS: 3 | US FAERS | |
| 43 | Epistaxis | FAERS: 3 | US FAERS | |
| 44 | Eructation | FAERS: 3 | US FAERS | |
| 45 | Hospice Care | FAERS: 3 | US FAERS | |
| 46 | Intentional dose omission | FAERS: 3 | US FAERS | |
| 47 | Oropharyngeal pain | FAERS: 3 | US FAERS | |
| 48 | Prescribed underdose | FAERS: 3 | US FAERS | |
| 49 | Pruritus | FAERS: 3 | US FAERS | |
| 50 | Thirst | FAERS: 3 | US FAERS | |
| 51 | Tremor | FAERS: 3 | US FAERS | |
| 52 | Abdominal tenderness | FAERS: 2 | US FAERS | |
| 53 | Alanine Aminotransferase Increased | FAERS: 2 | US FAERS | |
| 54 | Bladder spasm | FAERS: 2 | US FAERS | |
| 55 | Blood creatinine increased | FAERS: 2 | US FAERS | |
| 56 | Bone pain | FAERS: 2 | US FAERS | |
| 57 | Burning sensation | FAERS: 2 | US FAERS | |
| 58 | Chills | FAERS: 2 | US FAERS | |
| 59 | Disease Progression | FAERS: 2 | US FAERS | |
| 60 | Dysphemia | FAERS: 2 | US FAERS | |
| 61 | Dysphonia | FAERS: 2 | US FAERS | |
| 62 | Dysuria | FAERS: 2 | US FAERS | |
| 63 | Early satiety | FAERS: 2 | US FAERS | |
| 64 | Escherichia sepsis | FAERS: 2 | US FAERS | |
| 65 | Escherichia urinary tract infection | FAERS: 2 | US FAERS | |
| 66 | Gastritis | FAERS: 2 | US FAERS | |
| 67 | Hypersensitivity | FAERS: 2 | US FAERS | |
| 68 | Infection | FAERS: 2 | US FAERS | |
| 69 | Onychalgia | FAERS: 2 | US FAERS | |
| 70 | Pancreatitis | FAERS: 2 | US FAERS | |
| 71 | Productive Cough | FAERS: 2 | US FAERS | |
| 72 | Sneezing | FAERS: 2 | US FAERS | |
| 73 | Therapy change | FAERS: 2 | US FAERS | |
| 74 | Urinary tract discomfort | FAERS: 2 | US FAERS | |
| 75 | Visual Impairment | FAERS: 2 | US FAERS | |
| 76 | Accidental overdose | FAERS: 1 | US FAERS | |
| 77 | Amnesia | FAERS: 1 | US FAERS | |
| 78 | Anal inflammation | FAERS: 1 | US FAERS | |
| 79 | Animal bite | FAERS: 1 | US FAERS | |
| 80 | Apparent life threatening event | FAERS: 1 | US FAERS | |
| 81 | Arthritis | FAERS: 1 | US FAERS | |
| 82 | Blood glucose decreased | FAERS: 1 | US FAERS | |
| 83 | Blood iron decreased | FAERS: 1 | US FAERS | |
| 84 | Bronchitis | FAERS: 1 | US FAERS | |
| 85 | Chest Pain | FAERS: 1 | US FAERS | |
| 86 | Chest discomfort | FAERS: 1 | US FAERS | |
| 87 | Chromaturia | FAERS: 1 | US FAERS | |
| 88 | Chronic Fatigue Syndrome | FAERS: 1 | US FAERS | |
| 89 | Clostridium difficile infection | FAERS: 1 | US FAERS | |
| 90 | Colitis | FAERS: 1 | US FAERS | |
| 91 | Conjunctivitis | FAERS: 1 | US FAERS | |
| 92 | Critical Illness | FAERS: 1 | US FAERS | |
| 93 | Cystitis | FAERS: 1 | US FAERS | |
| 94 | Depressed mood | FAERS: 1 | US FAERS | |
| 95 | Discomfort | FAERS: 1 | US FAERS | |
| 96 | Drug administered to patient of inappropriate age | FAERS: 1 | US FAERS | |
| 97 | Ecchymosis | FAERS: 1 | US FAERS | |
| 98 | Electrolyte imbalance | FAERS: 1 | US FAERS | |
| 99 | Emergency Care | FAERS: 1 | US FAERS | |
| 100 | Eye irritation | FAERS: 1 | US FAERS | |
| 101 | Feeling jittery | FAERS: 1 | US FAERS | |
| 102 | Flushing | FAERS: 1 | US FAERS | |
| 103 | Food Poisoning | FAERS: 1 | US FAERS | |
| 104 | Gastroenteritis | FAERS: 1 | US FAERS | |
| 105 | Gastrointestinal perforation | FAERS: 1 | US FAERS | |
| 106 | Gout | FAERS: 1 | US FAERS | |
| 107 | Hair growth rate abnormal | FAERS: 1 | US FAERS | |
| 108 | Hepatitis | FAERS: 1 | US FAERS | |
| 109 | Hordeolum | FAERS: 1 | US FAERS | |
| 110 | Impaired driving ability | FAERS: 1 | US FAERS | |
| 111 | Inappropriate schedule of drug administration | FAERS: 1 | US FAERS | |
| 112 | Influenza | FAERS: 1 | US FAERS | |
| 113 | Infrequent bowel movements | FAERS: 1 | US FAERS | |
| 114 | Intentional product use issue | FAERS: 1 | US FAERS | |
| 115 | Joint swelling | FAERS: 1 | US FAERS | |
| 116 | Lip swelling | FAERS: 1 | US FAERS | |
| 117 | Lower respiratory tract infection | FAERS: 1 | US FAERS | |
| 118 | Mental impairment | FAERS: 1 | US FAERS | |
| 119 | Metastatic Neoplasm | FAERS: 1 | US FAERS | |
| 120 | Mood swings | FAERS: 1 | US FAERS | |
| 121 | Mouth swelling | FAERS: 1 | US FAERS | |
| 122 | Musculoskeletal chest pain | FAERS: 1 | US FAERS | |
| 123 | Neck Pain | FAERS: 1 | US FAERS | |
| 124 | Negative thoughts | FAERS: 1 | US FAERS | |
| 125 | Nervousness | FAERS: 1 | US FAERS | |
| 126 | Neutropenia | FAERS: 1 | US FAERS | |
| 127 | Oral pain | FAERS: 1 | US FAERS | |
| 128 | Papule | FAERS: 1 | US FAERS | |
| 129 | Paranasal sinus hyposecretion | FAERS: 1 | US FAERS | |
| 130 | Pharyngitis | FAERS: 1 | US FAERS | |
| 131 | Physical disability | FAERS: 1 | US FAERS | |
| 132 | Pneumonia | FAERS: 1 | US FAERS | |
| 133 | Post procedural infection | FAERS: 1 | US FAERS | |
| 134 | Product packaging quantity issue | FAERS: 1 | US FAERS | |
| 135 | Rash erythematous | FAERS: 1 | US FAERS | |
| 136 | Recall phenomenon | FAERS: 1 | US FAERS | |
| 137 | Retching | FAERS: 1 | US FAERS | |
| 138 | Rubber sensitivity | FAERS: 1 | US FAERS | |
| 139 | Saliva altered | FAERS: 1 | US FAERS | |
| 140 | Sjogren's Syndrome | FAERS: 1 | US FAERS | |
| 141 | Slow speech | FAERS: 1 | US FAERS | |
| 142 | Sputum retention | FAERS: 1 | US FAERS | |
| 143 | Syncope | FAERS: 1 | US FAERS | |
| 144 | Therapy cessation | FAERS: 1 | US FAERS | |
| 145 | Thrombosis | FAERS: 1 | US FAERS | |
| 146 | Tongue erythema | FAERS: 1 | US FAERS | |
| 147 | Upper-airway cough syndrome | FAERS: 1 | US FAERS | |
| 148 | Urticaria | FAERS: 1 | US FAERS | |
| 149 | Vertigo | FAERS: 1 | US FAERS | |
| 150 | Vulvovaginal burning sensation | FAERS: 1 | US FAERS | |
| 151 | Vulvovaginal pain | FAERS: 1 | US FAERS | |
| 152 | Vulvovaginal pruritus | FAERS: 1 | US FAERS |
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